A5103186589- Plant-derived Lignans Synthesis and Bioactivity
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
- Histone Deacetylase Inhibitors Research
- Antibiotic Resistance in Bacteria
- Neuroinflammation and Neurodegeneration Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Natural Compound Pharmacology Studies
- Microtubule and mitosis dynamics
- Cardiac Fibrosis and Remodeling
- Axial and Atropisomeric Chirality Synthesis
- Inflammasome and immune disorders
- Synthesis of Organic Compounds
- Biological Activity of Diterpenoids and Biflavonoids
China Pharmaceutical University
2014-2024
Sanya Central Hospital
2023-2024
Jimei University
2024
Fudan University
2020
Nanjing Jiangning Hospital
2019
State Key Laboratory of Natural Medicine
2018
Nantong University
2012
Southwest University
2005
Xijing Hospital
2001
Air Force Medical University
2001
Pseudomonas aeruginosa is a significant pathogen mainly causing healthcare-associated infections (HAIs). Newly emerging high-risk clones of P. with elevated virulence profiles furtherly cause severe community-acquired (CAIs). Usually, it not common for to co-carry exoU and exoS genes, encoding two type III secretion system (T3SS) effectors. The pathogenicity mechanism exoS+/exoU+ strains remains unclear. Here, we provide detailed evidence subset hypervirulent strains, which abundantly...
Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and few studies have reported its anti-cancer effect. However, the in vivo antitumor efficacy of DPT is currently indeterminate. In this study, we investigated anti-gastric cancer effects both vitro vivo. Our data showed that inhibited cell proliferation induced G2/M cycle arrest accompanied by an increase apoptotic death SGC-7901 cells. addition, caused cyclin B1, Cdc2 Cdc25C to...
Increased lipogenesis and protein synthesis is a hallmark of cancer cell proliferation, survival, metastatic progression under intense investigation as potential antineoplastic target. Acetyltanshinone IIA (ATA) compound that was obtained from chemical modifications tanshinone (TIIA), potent anticancer agent extracted the dried roots Chinese herbal medicine Salvia miltiorrhiza Bunge. A previous indicated ATA more effective in inhibiting growth breast especially cells with HER2...
Multidrug resistance (MDR) is a common limitation for the clinical use of microtubule-targeting chemotherapeutic agents, and it main factor poor prognoses in cancer therapy. Here, we report on deoxypodophyllotoxin (DPT), promising microtubule inhibitor phase 1, as candidate to circumvent this obstacle. DPT remarkably suppressed tumor growth xenograft mice bearing either paclitaxel (PTX)-sensitive MCF-7/S or acquired MCF-7/Adr (MCF-7/A) cells. Also, exhibited similar accumulation both tumors,...
// Yurong Wang 1 , Bin Mounia Guerram Li Sun Wei Shi 2 Chongchong Tian Xiong Zhu 3 Zhenzhou Jiang 1,4 and Luyong Zhang 1,5 Jiangsu Key Laboratory of Drug Screening Center for Pharmacodynamics Research Evaluation, China Pharmaceutical University, Nanjing, P.R. Chia Tai Tianqing Group Co., Ltd, Medical Chemical Institute, 4 TCM Evaluation Translational Research, 5 State Natural Medicines, Correspondence to: Jiang, email: Zhang, Keywords : deoxypodophyllotoxin, tumor vasculature, cytoskeleton...
The evolution of drug-resistant bacteria poses a serious threat to public health; hence, it is imperative develop new and efficient antibiotics. Irresistin-16 (IRS-16) dual-target antibacterial candidate that affects folate biosynthesis membrane integrity exhibits potent lethality against various bacteria. In this study, series 1,3-diamino-7H-pyrrol[3,2-f]quinazoline (DAPQ) derivatives based on IRS-16 was designed synthesized identify outstanding candidates. most promising compound,...
In the title compound, C(16)H(16)N(2)O(3)S·C(5)H(5)N, benzene and thia-zole rings of Febuxostat [2-(3-cyano-4-isobut-yloxy)phenyl-4-methyl-5-thia-zolecarboxylic acid] mol-ecule are almost coplanar [dihedral angle = 2.4 (1)°]. The carboxyl group is with ring [O-C-C-C O-C-C-S torsion angles -0.7 (4) 0.6 (3)°, respectively]. pyridine crystallization linked to through an O-H⋯N hydrogen bond. A weak π-π stacking inter-action observed between mol-ecule, a centroid-centroid distance 3.7530 (18) Å.
A ruthenium-catalyzed C-H alkylation/cyclization sequence is presented to prepare silyl indenes with atom and step-economy. This domino reaction triggered by acyl silane-directed activation, an aldehyde controlled the following enol cyclization/condensation other than β-H elimination. The protocol tolerates a broad substitution pattern, further synthetic elaboration of allows access diverse range interesting indene indanone derivatives.
Shewanella algae is an emerging marine zoonotic pathogen. In this study, we first reported the infections in patients and animals Hainan Province, China. Currently, there still relatively little known about whole-genome characteristics of most tropical regions, including southern Here, sequenced 62 strains isolated from Province combined with whole genomes sequences 144 public databases to analyze genomic features. Phylogenetic analysis revealed that widely distributed environments both...