A5033088054- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Traditional Chinese Medicine Studies
- MXene and MAX Phase Materials
- Advanced biosensing and bioanalysis techniques
- Acute Ischemic Stroke Management
- 2D Materials and Applications
- Graphene and Nanomaterials Applications
- Advanced Photocatalysis Techniques
- Barrier Structure and Function Studies
- Kruppel-like factors research
- Erythropoietin and Anemia Treatment
- biodegradable polymer synthesis and properties
- Graphene research and applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiovascular Health and Risk Factors
- Education and Work Dynamics
- Natural Compounds in Disease Treatment
- Medicinal Plants and Bioactive Compounds
- Extracellular vesicles in disease
- Inflammation biomarkers and pathways
- Problem Solving Skills Development
- Sphingolipid Metabolism and Signaling
- Cancer-related molecular mechanisms research
Nanjing Drum Tower Hospital
2003-2025
Imperial College London
2024
Nanjing University
2007-2021
Nanjing University of Chinese Medicine
2009-2021
Pharmaceutical Biotechnology (Czechia)
2020-2021
State Key Laboratory of Pharmaceutical Biotechnology
2017-2021
Jiangsu Province Hospital
2021
Jiangsu Province Blood Center
2020-2021
National Institutes of Health
2020
Yale University
2020
Background and Purpose— Oligodendrogenesis is essential for white matter repair after stroke. Although agonists of peroxisome proliferator–activated receptors γ confer neuroprotection in models cerebral ischemia, it not known whether this effect extends to protection. This study tested the hypothesis that agonist rosiglitazone enhances oligodendrogenesis improves long-term integrity ischemia/reperfusion. Methods— Male adult C57/BL6 mice (25–30 g) were subjected 60-minute middle artery...
Geoffrey J. Lindeman, Lina Dagnino, Stefan Gaubatz, Yuhui Xu, Roderick T. Bronson, Henry B. Warren, and David M. Livingston The Dana-Farber Cancer Institute/Harvard Medical School, Boston, Massachusetts 02115 USA; Ottawa General Hospital Research Institute, Ottawa, Ontario K1H 8L6 Canada; Tufts University School of Veterinary Medicine, 02111 Center for Animal Resources Comparative Medicine/Harvard USA
Treatment with sodium tanshinone IIA sulfonate (STS) may ameliorate blood-brain barrier (BBB) damage in acute ischemic stroke patients receiving recombinant tissue plasminogen activator (rt-PA) thrombolysis and improve patients' outcome. This randomized, single-center, placebo-controlled clinical trial investigated the potential effects underlying mechanisms of STS. Forty-two intravenous rt-PA were randomized to administration either STS (60 mg/day) (n = 21) or equivalent volume saline as a...
Abstract Arsenene has recently emerged as a promising new two‐dimensional material for biomedical applications because of its excellent optical and electronic properties. Herein, novel 2D arsenene nanosheets were synthesized shown to be effective against NB4 promyelocytic leukaemia (APL) cells (82 % inhibition) well inducing apoptosis while showing no toxicity towards normal cells. The high zeta potential, small size, the planar structure crucial materials. Label‐free proteomic profiling...
Black phosphorus nanosheets (BPNSs) have substantially promoted biomedical nanotechnology due to their unique photothermal and chemotherapeutic properties. However, there is still a limited molecular understanding of the effects bio-nano interfaces on BPNSs subsequent impacts physiological systems. Here, it shown that black phosphorus-corona complexes (BPCCs) could function as immune modulators promote polarization macrophages. Mechanistically, BPCCs interact with calmodulin activate stromal...
Introduction: Post-stroke neuroinflammation is a hallmark of ischemic stroke. This study investigates the role IGSF6 in microglia during stroke and its contribution to neuroinflammatory responses brain injury following Methods: expression was examined murine under various inflammatory stimuli. Using middle cerebral artery occlusion (MCAO) model, we evaluated impact microglial Igsf6 knockdown ( -KD) on outcomes. Pro-inflammatory cytokine levels were measured using qPCR ELISA both -KD...
Abstract Polyphosphate (PolyP) is one of the most compact inorganic polyanionic biopolymers that participates in various physiological processes. However, mechanism interaction between polyP and proteins remains poorly understood. Herein, we report can interact with positively charged green fluorescent protein, +36GFP, resulting liquid–liquid phase separation (LLPS) by intermolecular electrostatic interactions cells. Upon nutrient deprivation, genetically engineered Citrobacter freundii...
Among phosphorus-based nanomaterials, layered black phosphorus and violet have been actively explored in the past decade. However, methods for synthesis of red nanosheets (RPNSs) is lacking, even though (RP) commercially available at low cost has excellent chemical stability room temperature. We report an efficient strategy fabrication RPNSs doped using cysteine as a reducing reagent. Data from vitro vivo studies suggested that can trigger production reactive oxygen species, DNA damage,...
Abstract Classically, estrogen acts on cells by directly activating gene transcription driven ligand‐bound nuclear receptors (ER). Accumulating evidence demonstrates that neurons utilizing diverse molecular mechanisms, including rapid signaling proteins localized to the plasma membrane. Recent studies showing ERα localizes axons and dendrites of hippocampal suggest nonnuclear stores receptor may transduce signaling. Here, we have studied subcellular localization, dynamic regulation, function...
Paclitaxel (PTX) is widely used as a radiosensitizer in the clinical treatment of cancer. However, efficacy chemoradiotherapy limited by hostility tumor microenvironment such hypoxia. To overcome this constraint, we designed pleiotropic radiotherapy sensitized liposomes containing perfluorotributylamine (PFTBA) and PTX. The results showed that significantly accumulated site. PFTBA dramatically reversed hypoxia improved sensitivity radiotherapy. PTX blocked cell cycle cells...
Cerebral venous sinus thrombosis (CVST) is a rare ischemic cerebrovascular disease. The aim of this retrospective observational study was to investigate the risk factors for complication cerebral by seizures and explore impact such on clinical outcomes. Patients with or without epileptic were retrospectively analyzed compared in terms variables, causative factors, presentation, imaging data. In all, 69 patients enrolled study, 32 (46.38%) whom had experienced secondary seizures. Compared...
Spinal cord injury (SCI) is a traumatic central nervous system disorder that leads to permanent functional loss, and unavailable treatment of this disease results in poor quality life. However, the specific role long non-coding RNA small nucleolar host gene 14 (lncRNA SNHG14) SCI has not been fully studied. The aim current study was investigate SNHG14 its regulatory mechanism lipopolysaccharide (LPS)-induced PC-12 cells. LPS used stimulate cells simulate inflammatory following <em>in...
Background: Based on accumulating evidence, excessive activation of microglia-mediated inflammatory responses plays an essential role in ischemic stroke. Poncirin (Pon) exerts anti-hyperalgesic, anti-osteoporotic and anti-tumor effects various diseases. However, the roles Pon microglial underlying mechanism have not been elucidated. This study aimed to explore whether inhibits lipopolysaccharide (LPS)-induced neuroinflammation protects against brain injury experimental stroke mice. Methods:...
Previous studies have revealed that Triptolide damages female reproductive capacity, but the mechanism is unclear. In this study, we used Caenorhabditis elegans to investigate effects of on germline and explore its possible mechanisms. Our data show exposure for 4 h 50 100 mg/L reduced C. fertility, led depletion inactivation spermatids with changes in expression levels related genes, increased number unfertilized oocytes through damaging chromosomes DNA damage repair After 24 48 Triptolide,...
Open AccessCCS ChemistryRESEARCH ARTICLE1 Apr 2021Oxidized Black Phosphorus Nanosheets as an Inorganic Antiresorptive Agent Yun Xu†, Jianbin Mo†, Wei and Jing Zhao Xu† State Key Laboratory of Coordination Chemistry, Chemistry Biomedicine Innovation Center (ChemBIC), School Chemical Engineering, Nanjing University, 210093 Pharmaceutical Biotechnology, Life Sciences, , Mo† *Corresponding authors: E-mail Address: [email protected] https://doi.org/10.31635/ccschem.020.202000212...
Abstract Arsenene has recently emerged as a promising new two‐dimensional material for biomedical applications because of its excellent optical and electronic properties. Herein, novel 2D arsenene nanosheets were synthesized shown to be effective against NB4 promyelocytic leukaemia (APL) cells (82 % inhibition) well inducing apoptosis while showing no toxicity towards normal cells. The high zeta potential, small size, the planar structure crucial materials. Label‐free proteomic profiling...
Abstract Polyphosphate (PolyP) is one of the most compact inorganic polyanionic biopolymers that participates in various physiological processes. However, mechanism interaction between polyP and proteins remains poorly understood. Herein, we report can interact with positively charged green fluorescent protein, +36GFP, resulting liquid–liquid phase separation (LLPS) by intermolecular electrostatic interactions cells. Upon nutrient deprivation, genetically engineered Citrobacter freundii...
347 special education teachers were used as subjects, and the relationship among career commitment, satisfaction burnout investigated by questionnaire survey. The result showed: Career commitment had a significant positive effect on satisfaction, it negative burnout; predictive burnout, was complete mediator variable of burnout. Therefore, played an important role in maintaining teachers’ effectively avoiding their
Cerebral small vessel disease (CSVD) refers to the syndromes of clinical, cognitive, radiographic and pathological manifestations caused by intracranial disease. Due insidious onset CSVD, unknown etiology, diverse clinical manifestations, better short-term prognosis, it is easily ignored, resulting in misdiagnosis, missed diagnosis, non-standard diagnosis treatment. This article reviews advances research on imaging features, treatment CSVD. Key words: Cerebral Small Vessel...
The pathology of Alzheimer's disease (AD) includes β-amyloid (Aβ) (plaques) and neurofibrillary tangles (NFTs). This study aimed to explore the efficacy Huatuo Zaizao pill (HTZP) in an AD mouse model induced by injecting Aβ1-42, neuroprotective mechanism HTZP AD.C57BL/6 (B6) mice were randomly divided into 4 groups (n = 10, per group): control group, 2 different doses treated groups. Morris water maze test was carried out on assess learning ability after treatment with for 15 day. levels...