A5049563925- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Vascular Procedures and Complications
- Diagnosis and Treatment of Venous Diseases
- Central Venous Catheters and Hemodialysis
- Cerebrovascular and Carotid Artery Diseases
- Renal and Vascular Pathologies
- Angiogenesis and VEGF in Cancer
- Aortic aneurysm repair treatments
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Biomedical Ethics and Regulation
- Cardiac tumors and thrombi
- Cardiovascular and Diving-Related Complications
- Atrial Fibrillation Management and Outcomes
- Vascular anomalies and interventions
- Muscle and Compartmental Disorders
- Case Reports on Hematomas
- Abdominal vascular conditions and treatments
- Spinal Fractures and Fixation Techniques
- Pulmonary Hypertension Research and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Effects of Exercise
- Dialysis and Renal Disease Management
Massachusetts General Hospital
2014-2024
Harvard University
2011-2023
Portland VA Medical Center
2019
Boston Medical Center
2012-2014
Northwestern Memorial Hospital
2012
Northwestern University
2012
Harvard University Press
2009-2011
St. Elizabeth's Medical Center
1999-2009
Austin Hospital
2009
Chinese University of Hong Kong
2009
Background Clinical studies have suggested that smooth muscle cell (SMC) hyperplasia is the most likely cause of in-stent restenosis. However, pathological data regarding this issue are limited. Specifically, direct evidence proliferative activity in tissues excised from stenotic stents has not been previously reported. Methods and Results Tissue specimens were retrieved by directional atherectomy 10 patients whom restenosis complicated percutaneous revascularization peripheral artery...
Critical limb ischemia portends a risk of major amputation 25% to 35% within 1 year diagnosis. Preclinical studies provide evidence that intramuscular injection autologous CD34+ cells improves perfusion and reduces risk. In this randomized, double-blind, placebo-controlled pilot study, we evaluated the safety efficacy injections in subjects with moderate or high-risk critical ischemia, who were poor noncandidates for surgical percutaneous revascularization (ACT34-CLI).
Background: Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular permeability. The extent to which VEGF may cause tissue edema in humans has not been established. Objective: To evaluate patients undergoing gene transfer for evidence of lower-extremity edema. Design: Prospective consecutive case series. Setting: Hospital outpatient clinic. Patients: 62 with critical limb ischemia 28 claudication. Intervention: Gene DNA. Measurements: Semiquantitative analysis Results:...
Few studies have documented relationships between endovascular therapy, duplex ultrasonography (DUS), post-thrombotic syndrome (PTS), and quality of life (QOL). The Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) trial randomized 692 patients acute proximal deep vein thrombosis (DVT) to receive anticoagulation or plus pharmacomechanical catheter-directed thrombolysis (PCDT). Compression DUS was obtained at baseline, 1 month 12 months. Reflux...
Intravascular ultrasound (IVUS) is useful in evaluating coronary stent deployment. The aim of this study was to assess the safety and utility IVUS carotid artery stenting (CAS). Ninety-eight consecutive high-risk patients (107 arteries) underwent CAS. performed prior predilatation 87 107 vessels all following deployment when an optimal angiographic appearance obtained. Quantitative angiography (QCA) analysis were offline. Procedural success 97%. Combined stroke or death at 30 days 5.6%....
Background and Purpose— We aimed to investigate the incidence of May-Thurner syndrome in patients with cryptogenic stroke patent foramen ovale. Methods— This was a retrospective study. All consecutive having undergone ovale closure from January 1, 2002, December 31, 2007, at our institute were included this Pelvic magnetic resonance venography studies all reviewed determine if features present. Medical records invasive when available. on by vascular medicine specialist define any previous...
Scientific Abstract "Restenosis" is the term which has been used to denote recurrent narrowing of a blood vessel after an initially successful revascularization procedure, such as percutaneous transluminal angioplasty (PTA). Despite fact that PTA now widely treat atherosclerotic obstructions in coronary and peripheral vascular circulations for nearly three decades, restenosis continues be vexing, consequently expensive, complication this otherwise efficacious intervention. In certain regions...
Supra-normal ankle brachial index (ABI) (>1.40), poses diagnostic challenges to determine the presence, location, and severity of peripheral artery disease (PAD). The anatomic distribution PAD in patients with elevated ABI has not been previously described.A retrospective review all referred Massachusetts General Hospital vascular laboratory from 5 January 2006 12 2011 who had both a supra-normal contrast arteriography (CA) within 3 months each other is reported. Angiographic patterns were...
Spontaneous isolated celiac or superior mesenteric artery (SMA) dissection (SICMAD) is a rare clinical entity. Not much known about the natural history and appropriate treatment. We retrospectively queried prospectively collected institutional radiology database for all patients diagnosed with SICMAD from 1990 to 2017. identified 42 arteries in 40 (83.3% male), mean age 54.8 ± 10.9 years, consisting of 24 18 SMA. SMA lesions were longer than (5.15 3.81 vs 2.38 1.40 cm, p = 0.008). Thirty-one...
Racial disparities exist in patients with peripheral artery disease (PAD), Black individuals having worse PAD-specific outcomes. However, mortality risk this population has been mixed. As such, we sought to evaluate all-cause by race among PAD.We analyzed data from the National Health and Nutrition Examination Survey (NHANES). Baseline were obtained 1999 2004. Patients PAD grouped according self-reported race. Multivariable Cox proportional hazards regression was performed calculate adjusted...
Abstract Objective : To evaluate the effect of glycoprotein IIb/IIIa inhibition during nitinol stenting, superficial femoral occlusive disease. Background Stent implantation in artery has been associated with suboptimal results while Glycoprotein inhibitors have shown improved procedural coronary intervention. We evaluated abciximab infusion (Smart Stent®) obstructions. Methods: conducted a randomized placebo controlled trial. The two primary end points include: (1) 9‐month restenosis...