A5085105811- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Fatty Acid Research and Health
- Neuropeptides and Animal Physiology
- Infective Endocarditis Diagnosis and Management
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Migraine and Headache Studies
- Exercise and Physiological Responses
- Pain Management and Placebo Effect
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Pediatric Pain Management Techniques
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Acupuncture Treatment Research Studies
- Burn Injury Management and Outcomes
- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Indigenous Health, Education, and Rights
University of Kansas Medical Center
2014-2024
University of Kansas
2013-2023
Amway (United States)
2023
Bristol Royal Hospital for Children
2016
St Vincent's Hospital
2011-2012
Pain and Dependence The properties functions of µ-opioid receptors have been studied intensively with respect to the binding endogenous or exogenous ligands. However, much less is known about constitutive, ligand-independent, activation opioid receptors. Working in mice, Corder et al. (p. 1394 ) observed prolonged constitutive spinal dorsal horn after transient peripheral inflammation. results suggest that depresses nociception—the perception pain—for long periods time induces cellular...
Musculoskeletal pain affects nearly half of all adults, most whom are vitamin D deficient. Previous findings demonstrated that putative nociceptors (“pain-sensing” nerves) express receptors (VDRs), suggesting responsiveness to 1,25-dihydroxyvitamin D. In the present study, rats receiving D-deficient diets for 2–4 weeks showed mechanical deep muscle hypersensitivity, but not cutaneous hypersensitivity. Muscle hypersensitivity was accompanied by balance deficits and occurred before onset overt...
( Headache 2011;51:674‐692) Objective.— The objectives of this study were to develop a preclinical rodent model that produces migraine‐like behaviors based on International Society diagnostic criteria, determine whether sex differences are present, and expression calcitonin gene‐related peptide (CGRP) the genes encoding its receptor in trigeminal ganglion or medulla correlates with those behaviors. Background.— Few animal studies migraine have tested associated criteria. In study, changes...
Peripheral nerve injury sensitizes a complex network of spinal cord dorsal horn (DH) neurons to produce allodynia and neuropathic pain. The identification druggable target within this has remained elusive, but promising candidate is the neuropeptide Y (NPY) Y1 receptor-expressing interneuron (Y1-IN) population. We report that spared (SNI) enhanced excitability Y1-INs elicited (mechanical cold hypersensitivity) affective Similarly, chemogenetic or optogenetic activation in uninjured mice...
Significance Cutaneous sensitivity appears to be abnormal in Rett syndrome and other autistic disorders. Using rats with disrupted methyl-CpG binding protein 2 (MeCP2) expression characteristic of syndrome, we found that MeCP2 deficiency sensory neurons led augmented pressure cold but hyposensitivity heat, accompanied by respective changes cutaneous innervation. Transcriptome analysis MeCP2-deficient ganglia showed up-regulation genes associated actin cytoskeletal dynamics adhesion...
Exposure to stress early in life has been associated with adult-onset comorbidities such as chronic pain, metabolic dysregulation, obesity, and inactivity. We have established an early-life model using neonatal maternal separation (NMS) mice, which displays evidence of increased body weight adiposity, widespread mechanical allodynia, hypothalamic-pituitary-adrenal axis dysregulation male mice. Early-life consumption a Western-style diet contribute the development obesity; however, relatively...
Decreased tissue levels of n-3 (omega-3) fatty acids, particularly docosahexaenoic acid (DHA), are implicated in the etiologies non-puerperal and postpartum depression. This study examined effects a diet-induced loss brain DHA content concurrent reproductive status on dopaminergic parameters adult female Long–Evans rats. An α-linolenic acid-deficient diet breeding protocols were used to produce virgin parous rats with cortical phospholipid 20–22% lower than those fed control containing...
Migraine is a common and debilitating neurological disorder suffered worldwide. Women experience this condition 3 times more frequently than men, with estrogen strongly implicated to play role. Bisphenol A (BPA), highly prevalent xenoestrogen, known have estrogenic activity may an effect in migraine onset, intensity, duration through receptor signaling. It was hypothesized that BPA exposure exacerbates symptoms signaling downstream activation of nociception related pathways. Utilizing...
Open-field behavioral scoring is widely used to assess spinal cord injury (SCI) outcomes, but has limited usefulness in describing subtle changes important for posture and locomotion. Additional quantitative methods are needed increase the resolution of locomotor outcome assessment. This study gait analysis at multiple speeds (GAMS) across a range mild-to-severe intensities thoracic SCI rat. Overall, Basso, Beattie, Bresnahan (BBB) scores subscores were assessed, detailed automated was...
The purpose of this study was to examine neuronal activity levels in the hindlimb area motor cortex following spinal cord injury (SCI) rats and compare results with measurements normal rats. Fifteen male Fischer-344 received a 200 Kdyn contusion thoracic at level T9–T10. After minimum 4 weeks SCI, intracortical microstimulation (ICMS) single-unit recording techniques were used both forelimb areas (FLA, HLA) under ketamine anesthesia. Although movements could be evoked using ICMS relatively...
Rett Syndrome (RTT), an autism-related disorder caused by mutation of the X-linked Methyl CpG-binding Protein 2 (MECP2) gene, is characterized severe cognitive and intellectual deficits. While deficits are well-documented in humans rodent models, impairments sensory, motor metabolic functions also occur but remain poorly understood. To better understand non-cognitive RTT, we studied female rats heterozygous for Mecp2 (Mecp2-/x); unlike commonly used male Mecp2-/y this more closely...
Neuropeptide Y (NPY) Y2 receptor (Y2) antagonist BIIE0246 can both inhibit and facilitate nociception. The authors hypothesized that function depends on inflammation or nerve injury status.
There is evidence that aerobic exercise beneficial for brain health, but these effects are variable between individuals and the underlying mechanisms modulate benefits remain unclear.
High levels of bilirubin in infants can cause kernicterus, which includes basal ganglia damage and dystonia. Stem cell transplantation may be an effective treatment for this disease. In study, we transplanted human neural progenitor cells differentiated toward propriospinal interneurons into the striatum 20-day-old spontaneously jaundiced (jj) Gunn rats nonjaundiced (Nj) littermates. Using immunohistochemical methods, found that grafted survived grew fibers jj Nj brains 3 weeks after...
Previous work has demonstrated that persistent nociception evokes increased neurokinin-1 receptor (NK-1) gene expression in the spinal cord dorsal horn of rat within 2 h but failed to elucidate relationship between NK-1 at later time points and functional regulation signaling. This study was undertaken assess changes mRNA levels models inflammatory hyperalgesia relate them coupling receptors G-protein activity rat. Thus, unilateral intraplantar formalin or complete Freund9s adjuvant used...