A5110680409- Cancer-related molecular mechanisms research
- Pain Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- Acute Myeloid Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Receptor Mechanisms and Effects
- Pancreatitis Pathology and Treatment
- Metabolism, Diabetes, and Cancer
- Viral gastroenteritis research and epidemiology
- Salivary Gland Disorders and Functions
- Kawasaki Disease and Coronary Complications
- Circular RNAs in diseases
- Hepatitis C virus research
- Neuropeptides and Animal Physiology
- Lipid metabolism and disorders
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Animal Virus Infections Studies
- Cancer, Hypoxia, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Chronic Lymphocytic Leukemia Research
- Cancer Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
Peking University
2023-2025
Peking University People's Hospital
2023-2025
Xinjiang Medical University
2024
Children's Hospital of Chongqing Medical University
2021
Chongqing Medical University
2021
Guilin Medical University
2019-2020
University of Illinois Chicago
2013
Zhejiang University
2013
Guangxi Medical University
2011
Capital Medical University
2010
Pain and Dependence The properties functions of µ-opioid receptors have been studied intensively with respect to the binding endogenous or exogenous ligands. However, much less is known about constitutive, ligand-independent, activation opioid receptors. Working in mice, Corder et al. (p. 1394 ) observed prolonged constitutive spinal dorsal horn after transient peripheral inflammation. results suggest that depresses nociception—the perception pain—for long periods time induces cellular...
BACKGROUND:This study aimed to investigate the association between levels of serum amyloid A (SAA) and activity systemic lupus erythematosus (SLE). MATERIAL AND METHODS:The included 135 patients with SLE, including 52 active SLE 83 inactive 149 healthy controls. The degree was assessed using Disease Activity Index 2000 (SLEDAI-2K). Serum SAA were measured a Cobas 8000 c702 modular analyzer. RESULTS:The significantly increased in compared (median IQR, 16.65 mg/L; range, 9.35–39.68 mg/L,...
Abstract Taurine‐upregulated gene 1 ( TUG1 ), a kind of long non‐coding RNAs (lncRNAs), was up‐regulated in ischaemic stroke (IS) with the function promoting neuron apoptosis. In this study, we aimed to investigate association polymorphisms IS risk. The were genotyped using custom‐by‐design 48‐Plex SNPscan kit. promoter activity measured dual luciferase reporter assay. Relative expression patients analysed quantitative PCR and binding rs2240183 polymorphism transcription factor chromatin...
A previous work has discovered that chromosome 1q32 locus linked to the risk of systemic lupus erythematosus (SLE) and miR-181b located on susceptibility site with downregulation inversely correlating its target molecular interferon alpha 1 (IFNA1). The purpose this study was investigate association IFNA1 polymorphisms IS risk.The rs322931, rs1332190, rs10811543 were genotyped using a Multiplex SNaPshot assay. expression levels in plasma SLE patients controls analyzed quantitative PCR.The...
Abstract Hypoxia-inducible factor-3α ( HIF-3α ), a member of HIF family, can mediate adaptive responses to low oxygen and ischemia. It is believed that plays crucial roles in stroke-related diseases. However, there are no reports on the association between genetic variants ischemic stroke (IS) susceptibility. Therefore, we examined HIF- 3α gene polymorphisms (rs3826795, rs2235095, rs3764609) IS risk. The study population included 302 controls 310 patients with stroke. Three were genotyped...
To evaluate the safety of patients with hepatic adenoma undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) .
Background: Echinococcosis is a zoonotic infectious disease that poses significant threat to the health of individuals living in rural regions. While vaccination represents potential strategy for prevention, there currently no effective vaccine available humans prevent cystic echinococcosis (CE). This study aimed design novel multi-epitope (MEV) against Echinococcus granulosus human use, employing immunoinformatics methods. Methods: We identified core epitopes from two key antigens, EgA31...
Genome-wide association study (GWAS) identified chromosome 12p13 rs12425791 and rs11833579 as susceptibility loci of ischemic stroke (IS) in a European population. However, conflicting results were obtained subsequent replication analysis. miR-200c, located on 12p13, was found to have neuroprotective effect ischemia. Our aim this investigate the rs12425791, rs12904 binding site miR-200c with risk IS. The rs11833579, genotyped using TaqMan allelic discrimination assay. verified by Sanger...
Objective: To compare the baseline difference in quantitative hepatitis B core antibody levels (qAnti-HBc) between non-response and response group children with HBeAg-positive chronic (CHB) who received antiviral therapy, further explore proportion functional activity of CD8 + memory T lymphocyte subsets different qAnti-HBC peripheral blood children. Methods: The anti-HBc quantification 85 CHB visited Department Infectious Diseases, Children's Hospital Chongqing Medical University from June...