A5003121532- South Asian Studies and Conflicts
- Parasitic Diseases Research and Treatment
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Monoclonal and Polyclonal Antibodies Research
- Politics and Conflicts in Afghanistan, Pakistan, and Middle East
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Cystic Fibrosis Research Advances
- Ethnobotanical and Medicinal Plants Studies
- Phytochemistry and Bioactive Compounds
- Synthesis and biological activity
- Tea Polyphenols and Effects
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Phytochemistry and Bioactivity Studies
- Glycosylation and Glycoproteins Research
- Medicinal Plants and Neuroprotection
- Carbohydrate Chemistry and Synthesis
- Fluid Dynamics and Turbulent Flows
- SARS-CoV-2 and COVID-19 Research
- Indian History and Philosophy
- Aerodynamics and Acoustics in Jet Flows
- Cholinesterase and Neurodegenerative Diseases
- Hepatitis Viruses Studies and Epidemiology
Jamia Hamdard
1997-2024
Madan Mohan Malaviya University of Technology
2022-2024
National Chemical Laboratory
2024
Institute of Medical Sciences
2024
Government Medical College
2024
Translational Health Science and Technology Institute
2018-2023
Jawaharlal Nehru University
2020-2023
SRM University
2023
Indian Institute of Technology Kanpur
2023
GD Goenka University
2022-2023
While Staphylococcus epidermidis is commonly isolated from healthy human skin, it also the most frequent cause of nosocomial infections on indwelling medical devices. Despite its importance, few genome sequences existed and hospital-associated lineage, ST2, had not been fully sequenced.We cultivated 71 commensal S. isolates 15 skin sites compared them with 28 venous catheters blood cultures. We produced 21 9 draft genomes, annotated their gene content, phylogenetic relatedness biochemical...
Next-generation sequencing of antibody transcripts from HIV-1-infected individuals with broadly neutralizing antibodies could provide an efficient means for identifying somatic variants and characterizing their lineages. Here, we used 454 pyrosequencing identity/divergence grid sampling to analyze heavy- light-chain sequences donor N152, the source 10E8. We identified up 28% difference in amino acid sequence. Heavy- phylogenetic trees 10E8 displayed similar architectures, reconstituted...
Hepatitis E virus (HEV) causes an acute, self-limiting hepatitis. The disease takes a severe form in pregnant women, leading to around 30% mortality. Zinc is essential micronutrient that plays crucial role multiple cellular processes. Our earlier findings demonstrated the antiviral activity of zinc salts against HEV infection. oxide (ZnO) and its nanostructures have attracted marked interest due their unique characteristics. Here we synthesized ZnO nanoparticles [ZnO(NP)] tetrapod-shaped...
Bacterial whole-genome sequencing (WGS) of human pathogens has provided unprecedented insights into the evolution antibiotic resistance. Most studies have focused on identification resistance mutations, leaving one to speculate fate these mutants once selective pressure is removed. We performed WGS longitudinal isolates Acinetobacter baumannii from patients undergoing colistin treatment, and upon subsequent drug withdrawal. In each four patients, evolved via mutations at pmr locus. Upon...
Abstract Developing predictive animal models to assess how candidate vaccines and infection influence the ontogenies of Envelope (Env)-specific antibodies is critical for development an HIV vaccine. Here we use two nonhuman primate compare roles antigen persistence, diversity innate immunity. We perform longitudinal analyses Env-specific B-cell receptor responses SHIV AD8 Env protein vaccination with eight different adjuvants. A subset -infected animals higher viral loads greater show...
Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation expression genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day 112 (0.3 to >50 kb) occurs the rat pineal gland, which is source melatonin, hormone night. Approximately one-half these changes reflect nocturnal increases. Studies eight with 2- >100-fold daily rhythms indicate that, most cases, change results from neural...
In the current report, we have rationally designed a series of uracil-coumarin based bifunctional molecular hybrids roped by 1,2,3-triazole moiety. The compounds were synthesized and tested against panel six human cancer cell lines namely Colo-205, MCF-7, A-549, PA-1, PC-3 Hela cells Sulforhodamine B assay. results indicated that hybrid molecules can specifically inhibit MCF-7 proliferation amongst which A-2 was found to be most potent (GI50 = 1.55 µM) with fluorine atom as R two carbon...
Sialic acid-recognizing Ig-like lectins (Siglecs) are signaling receptors that modulate immune responses, and targeted for interactions by certain pathogens. We describe two primate Siglecs were rendered nonfunctional single genetic events during hominin evolution after our common ancestor with the chimpanzee. SIGLEC13 was deleted an Alu-mediated recombination event, a base pair deletion disrupted ORF of SIGLEC17. Siglec-13 is expressed on chimpanzee monocytes, innate cells react to...
To evaluate the antidiabetic potential of methanolic extract Albizia odoratissima Benth. bark in alloxan induced diabetic mice. Group-I(normal control) mice received only basal diet without any treatment. In Group– II(Diabetic mice, diabetes was by (150 mg/kg i.p.) and Tween 80, 5% v/v normal saline. III IV metformin (10mg/kg) gliclazide (10 mg/kg) as standard drugs. V VI odoratissimaat doses 250 500 body weight p.o., respectively. The results study indicates that significantly (P<0.01)...
To present a detailed pharmacognostic study of the leaf Cayratia trifolia (C. trifolia) Linn. (Vitaceae), an important plant in Indian system medicine.The macroscopy, microscopy, physiochemical analysis, preliminary testing, fluorescence analysis powder and other WHO recommended methods for standardization were investigated.Leaves are trifoliolated with petioles (2-3 cm) long. Leaflets ovate to oblong-ovate, (2-8 long, (1.5-5 wide, pointed at tip. The surface shows anisocytic type stomata...
Pancreatic cancer (PC) is a disease of insidious onset and late clinical presentation with an annual incidence 100 per million population. Itis the sixth most common cause mortality from records median survival about 3–6 months without treatment. Quality life (QOL) major consideration in management advanced cancer. PC adversely affects QOL sufferers mostly presents abdominal pain intra- extra-pancreatic origins. Opioids are "Gold-standard" treatment severe management. However, its use may be...
Introduction: Intraoperative awareness with explicit recall (AWR) occurs when an individual retains memory of intraoperative events after completion anesthesia. It is unpleasant feeling feared by both the patients and anesthetists. Objective: This research aims to compare Bispectral Index (BIS) versus Minimum Alveolar Concentration (MAC) guided anesthesia for assessment intra-operative in undergoing laparoscopic abdominal surgery. Methods: a prospective comparison involving 100 divided into...
To evaluate the gastric anti-ulcer activity of methanolic extract Cayratia trifolia L. (MECT) (Vitaceae) leaves in experimental animals. MECT was investigated pylorus ligation and ethanol induced ulcer models Wistar rats. In both models, common parameter determined index. at doses 250, 500 mg/kg (p.o.) used to determine whether it could produce significant inhibition lesions by ethanol. The (250 mg/kg) showed (P<0.05) reduction volume index as compared control two models. It can be concluded...