A5018436821- Inflammatory mediators and NSAID effects
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Gastroesophageal reflux and treatments
- Cancer, Hypoxia, and Metabolism
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Cancer, Stress, Anesthesia, and Immune Response
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
- Respiratory and Cough-Related Research
- Antimicrobial Peptides and Activities
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
- ATP Synthase and ATPases Research
- Wound Healing and Treatments
- RNA modifications and cancer
- Immune cells in cancer
- Pluripotent Stem Cells Research
- Mitochondrial Function and Pathology
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related molecular mechanisms research
- 3D Printing in Biomedical Research
- HIV Research and Treatment
South China University of Technology
2023-2025
Seagen (United States)
2024
Marshall University
2011-2018
Mesenchymal stem cell (MSC) therapies have been brought forward as a promising treatment modality for cutaneous wound healing. However, current approaches delivery many drawbacks, such lack of targetability and loss, leading to poor efficacy therapy. To overcome these problems, in the present study, an situ electrospinning system is developed attractive approach delivery. MSCs high viability over 90% even with applied voltage 15 kV post-cell process. In addition, does not show any negative...
ABSTRACT To date, generating viable and functional hepatocytes in large scale remains challenge. By employing 3D suspension condition with the support of low concentration Matrigel, a novel culture system was developed to generate expandable hepatoblast organoids (HB‐orgs) mature polarised hepatocyte (P‐hep‐orgs) from human embryonic stem cells (hESCs) both dishes bioreactors. scRNA‐seq assays were used characterise HB‐orgs P‐hep‐orgs. hESC‐derived could proliferate at least for 15 passages,...
<h3>Background</h3> Vedotin antibody-drug conjugates (ADCs), which incorporate the microtubule-disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable peptide linker, elicit antitumor activity through multiple potential mechanisms of action including MMAE-mediated cytotoxicity and immunogenic cell death (ICD). Mounting preclinical clinical evidence suggests combination vedotin ADC plus anti-PD1 immunotherapy elicits clinically meaningful responses. Using mouse model...
Abstract Cancer and highly proliferating normal cells have high demand for energy but paradoxically switch production from the efficient mitochondrial respiration to low cytosolic glycolysis. This phenomenon is known as Warburg effect, reason which not fully understood. study found that intracellular pH (pHi) induced apoptosis, whereas pHi enhanced proliferation, of lymphocytes. In tumor cells, also apoptosis maintained rates proliferation. draining mediastinal lymph nodes (MLNs) mice...
DNase I hypersensitive (DHS) sites are important for understanding cis regulation of gene expression. However, existing methods detecting DHS in small numbers cells can lead to ambiguous results. Here we describe a simple new method, which DNA fragments with ends generated by digestion isolated and used as templates two PCR reactions. In the first PCR, primers derived from sequences up- down-stream site. If site exists cells, will not produce products due cuts between primer sequences....
SUMMARY The role of intracellular pH (pHi) lymphocytes in the control magnitude immune response is unknown. We found that low pHi induces apoptosis proliferating lymphocytes, whereas high promotes their survival. In ovalbumin sensitization and challenge model, energy metabolism a major mechanism for regulating pHi. TCA cycle using carbohydrates lowers glutaminolysis or aerobic glycolysis increases Proliferation powered by mitochondrial membrane potentials (MMPs) but not causes apoptosis....
Estrogens have been linked to a higher female incidence of autoimmune diseases. The role androgen and the receptor (AR) in diseases, however, remains unclear. Here we report that lack AR B cells different strains mice, namely general knockout, cell-specific naturally occurring testicular feminization mutation AR-mutant as well castrated wild-type results increased blood bone marrow. Analysis targeted together with marrow transplantation using Rag1(-/-) recipients, overexpression retrovirally...
Abstract Pulmonary inflammation is a common pathological feature of variety diseases, ofwhich successful therapy with currently available anti-inflammatory drugs limited byresistance and adverse side effects. Using the ovalbumin-induced mouse allergic asthma model,the present study shows that treatments pH modifiers, particularly simple acids such asacetate or hydrochloric acid, effectively depleted inflammatory cells in lungs blood aswell as hyperplastic lung tissue while preserving...
Long non-coding RNA (lncRNA) signature has been reputable for the predetermination of cancer prognosis. In present study, we constructed a lncRNA model to predict survival outcomes hepatocellular carcinoma (HCC) patients. Using transcriptome data from TCGA HCC samples, identified that NEAT1 and MALAT1 were highly expressed in other tumor subtypes compared adjacent normal tissues. Based on LASSO Cox regression model, an eight-lncRNA significantly correlated with overall disease-free training...
Abstract Pulmonary inflammation is a common pathological feature of variety diseases, which successful therapy with currently available anti-inflammatory drugs limited by resistance and adverse side effects. Using the ovalbumin-induced mouse allergic asthma model, present study shows that treatments pH modifiers, particularly simple acids such as acetate or hydrochloric acid, effectively depleted inflammatory cells in lungs blood well hyperplastic lung tissue while preserving structure...