A5100393035- Reproductive System and Pregnancy
- interferon and immune responses
- Immune cells in cancer
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
- Asthma and respiratory diseases
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
- Circular RNAs in diseases
- Reproductive Health and Contraception
- RNA Research and Splicing
- Pregnancy and Medication Impact
- Invertebrate Immune Response Mechanisms
- Retinal Diseases and Treatments
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Aquaculture disease management and microbiota
- Eosinophilic Esophagitis
- Vibrio bacteria research studies
- Endometriosis Research and Treatment
- IL-33, ST2, and ILC Pathways
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
- RNA and protein synthesis mechanisms
Obstetrics and Gynecology Hospital of Fudan University
2012-2025
Chengdu University of Traditional Chinese Medicine
2023
Vanderbilt University
2021
First Affiliated Hospital of Guangzhou Medical University
2020
Guangzhou Medical University
2020
Beijing Chao-Yang Hospital
2020
Capital Medical University
2020
State Key Laboratory of Respiratory Disease
2020
Ocean University of China
2020
Abstract Background Age-related changes in the ovarian microenvironment are linked to impaired fertility women. Macrophages play important roles tissue homeostasis and immune surveillance. However, impact of aging on macrophage function remains poorly understood. Methods Senescence-associated beta-galactosidase staining, immunohistochemistry, TUNEL staining were used assess senescence apoptosis, respectively. Flow cytometry was employed evaluate mitochondrial membrane potential (MMP)...
ABSTRACT Gengnianchun (GNC) is a traditional remedy used for diminished ovarian reserve, but its underlying mechanisms remain unclear. This study aimed to explore these in human granulosa‐like cancer (KGN) cells pretreated with medicated rat serum (MRS) before H 2 O exposure. MRS pretreatment significantly alleviated ‐induced cell damage, including improvements viability, superoxide dismutase and GSH‐Px activities, Bcl‐2 expression. Conversely, treatment increased apoptosis, autophagosomes,...
Background Innate immunity to viruses involves receptors such as RIG-I, which senses viral RNA and triggers an IFN-β signaling pathway involving the outer mitochondrial membrane protein MAVS. However, functional status of MAVS phosphorylation remains elusive. Methodology/Principal Findings Here we demonstrate for first time that undergoes extensive tyrosine upon infection, indicating might play important role in function. A tyrosine-scanning mutational analysis revealed tyrosine-9 (Y9) is a...
The global shrimp industry has suffered bacterial diseases caused mainly by Vibrio species. typical vibriosis, acute hepatopancreatic necrosis disease (AHPND), resulted in mass mortality and devastating economic losses. Thus, therapeutic strategies are highly needed to decrease the risk of vibriosis outbreaks. Herein, we initially identified that growth causative agent AHPND, parahaemolyticus (VPAHPND) other vibrios Pacific white (Litopenaeus vannamei) was inhibited a Bacillus subtilis...
The role of intratumor heterogeneity is becoming increasingly apparent in part due to expansion single cell technologies. Clinically, tumor poses several obstacles effective cancer therapy dealing with biomarker variability and treatment responses. Matrix stiffening known occur during progression contribute pathogenesis hallmarks, including angiogenesis metastasis. However, the effects matrix on have not been thoroughly studied. In this study, we applied single-cell RNA sequencing...
Ethnopharmacological relevance: Mudan granule (MuD), a patent compound traditional Chinese medicine (TCM), is broadly clinically used for diabetic peripheral neuropathy (DPN) treatment in China. Since retinopathy (DR) and DPN are both 'Qi deficiency' collaterals obstruction syndrome TCM theory, it worthwhile to investigate the specific pharmacological effects of MuD on DR.Aim study: DR serious neurovascular complication mellitus (DM). The present study DR, further explore potential...
<p>PDF file - 1299K,A, Western blot detection of CHK1 and CHK2 in CNE2 cells. B, c-MYC, PKH26+ NPC cells after treated with c-Myc shRNA</p>
<div>Abstract<p>Radiotherapy is the most successful nonsurgical treatment for nasopharyngeal carcinoma (NPC). Despite this, prognosis remains poor. Although NPCs initially respond well to a full course of radiation, recurrence frequent. The cancer stem cell (CSC) hypothesis provides framework explaining discrepancy between response NPC therapy and poor survival rate. In this study, cell-like subpopulation (PKH26+) was identified in lines using label-retention technique. PKH26+...
This study aimed to understand the influence of naïve T cells in cytokine-induced killer (CIK) cell immunotherapy. A total 68 patients with advanced solid tumors received activated autologous CIK weekly. Objective responses (complete or partial responses, CR/PR) were observed 11 (16.2%, 11/68), five lasting more than 8 months, and 16 SD (23.5%, 16/68). The absolute number CD4+ who achieved CR/PR was higher PD (CR/PR vs PD= 90 149 226 cells/μL), as CD8+ 47 60 103 cells/μL). Patients high...