A5005741344- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Inflammatory Bowel Disease
- Microscopic Colitis
- Influenza Virus Research Studies
- LGBTQ Health, Identity, and Policy
- Eosinophilic Esophagitis
- Salmonella and Campylobacter epidemiology
- Food Safety and Hygiene
- Clostridium difficile and Clostridium perfringens research
- Adolescent and Pediatric Healthcare
- Liver Disease Diagnosis and Treatment
- Obesity and Health Practices
- Sex and Gender in Healthcare
- Animal Virus Infections Studies
- Liver Disease and Transplantation
- Child Nutrition and Water Access
- Geriatric Care and Nursing Homes
- COVID-19 epidemiological studies
- Homelessness and Social Issues
- Food Security and Health in Diverse Populations
- Healthcare Policy and Management
- Vaccine Coverage and Hesitancy
- Viral Infections and Immunology Research
- Listeria monocytogenes in Food Safety
University of Michigan–Ann Arbor
2022-2025
Michigan Medicine
2023-2025
Michigan United
2024
A. Alfred Taubman Health Care Center
2023
University of Washington
2018-2021
Emory University
2012-2021
Seattle University
2019
Georgia Department of Public Health
2017
Colorado School of Public Health
2012-2015
National Institute of Allergy and Infectious Diseases
2015
As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point of protection. Here, we profiled SARS-CoV-2-specific humoral responses in a cohort 22 hospitalized individuals. Despite inter-individual heterogeneity, distinct antibody signatures...
After its emergence in Wuhan, China, late November or early December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus rapidly spread globally. Genome sequencing of SARS-CoV-2 allows reconstruction transmission history, although this is contingent on sampling. We analyzed 453 genomes collected between 20 February and 15 March 2020 from infected patients Washington state United States. find that most infections sampled during time derive a single introduction...
The outbreak of bubonic plague that struck London and Westminster in 1636 provoked the usual frenzied response to epidemics, including popular flight government-mandated quarantine. government asserted control measures were acts public health for benefit all. However, contrary this narrative disease prevention there was a account portrayed quarantine isolation as personal punishment rather than prudent policy. In examining on parish well individual level, reasons inconsistency between...
Homeless shelters are a high-risk setting for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission because of crowding and shared hygiene facilities.
Noroviruses (NoV) are the most common cause of epidemic gastroenteritis world-wide. NoV infections often asymptomatic, although individuals still shed large amounts in their stool. Understanding differences between asymptomatic and symptomatic would help elucidating mechanisms pathogenesis. Our goal was to compare serum cytokine responses faecal viral RNA titres NoV-infected individuals. We tested samples from infected subjects (n = 26; 19 symptomatic, seven asymptomatic) two human challenge...
Objective: To describe the incidence and risk factors for mortality morbidity in patients with cirrhosis undergoing elective or emergent abdominal surgeries. Background: Postoperative are higher cirrhosis; variation by surgical procedure type severity remain unclear. Methods: We analyzed prospectively-collected data from Veterans Affairs (VA) Surgical Quality Improvement Program 8193 cirrhosis, 864 noncirrhotic controls chronic hepatitis B infection, 5468 without liver disease, who underwent...
Introduction: Evidence-based recommendations for sexual practices regarding anal receptive intercourse (ARI) do not exist in patients with inflammatory bowel diseases (IBD) undergoing restorative proctocolectomy ileal-pouch anastomosis (IPAA). This study surveys providers on perspectives and attitudes related to post-IPAA. Methods: We developed a 23-item survey distributed it caring IBD. Results: 95% of think that is important discuss orientation or before IPAA, but only 27% routinely this....
To improve food safety on farms, it is critical to quantify the impact of environmental microbial contamination sources fresh produce. However, studies are hampered by difficulties achieving study designs with powered sample sizes elucidate relationships between and produce contamination. Our goal was quantify, in agricultural production environment, relationship hands, soil, water In 11 farms packing facilities northern Mexico, we applied a matched design: composite samples (n = 636,...
Introduction Influenza epidemics and pandemics cause significant morbidity mortality. An effective response to a potential pandemic requires the infrastructure rapidly detect, characterise, potentially contain new emerging influenza strains at both an individual population level. The objective of this study is use data gathered simultaneously from community hospital sites develop model how enters spreads in population. Methods analysis Starting 2018–2019 season, we have been enrolling...
Noroviruses (NoV) are the most common cause of epidemic gastroenteritis worldwide. The acute immune response to NoV in humans is poorly understood, hindering research on prevention and treatment. To elucidate test for cytokine predictors susceptibility infection, serum samples from two human challenge studies were tested 16 cytokines. Subjects who became infected (n = 26) age-matched with subjects remained uninfected following 26). Samples prechallenge days 1-4 post-challenge. Cytokine...
Men who have sex with men (MSM) are at risk for sexual transmission of enteric pathogens. The microbiology gastroenteritis in MSM has not been examined since the advent antiretroviral therapy and molecular diagnostics. Our objective was to assess causes among living without human immunodeficiency virus (HIV) coinfection Seattle, Washington.We conducted a retrospective cohort study 235 underwent multiplex stool polymerase chain reaction (PCR) testing between 1 January 2017 June 2018. We...
Noninfluenza respiratory viruses are responsible for a substantial burden of disease in the United States. Household transmission is thought to contribute significantly subsequent through broader community. In context coronavirus 2019 (COVID-19) pandemic, contactless surveillance methods particular importance.
Chronic kidney disease of unknown origin (CKDu) is an epidemic that disproportionately affects young agriculture workers in hot regions. It has been hypothesized repeated acute injury (AKI) may play a role the development disease.Latent class mixed models were used to identify groups Guatemalan sugarcane harvesters based on their daily changes creatinine over 6 consecutive days 2018. Exponential smoothing state space forecast end-of-season between identified groups. Percent change estimated...