A5018137630- Reproductive tract infections research
- Multiple Myeloma Research and Treatments
- Syphilis Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Long-Term Effects of COVID-19
- Bacterial Infections and Vaccines
- Adolescent Sexual and Reproductive Health
- Cervical Cancer and HPV Research
- Health Services Management and Policy
- Female Genital Mutilation/Cutting Issues
- Cancer Treatment and Pharmacology
- Sex work and related issues
- Pelvic floor disorders treatments
- Blood disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Healthcare innovation and challenges
- Hepatitis C virus research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- COVID-19 Clinical Research Studies
- Genital Health and Disease
NHS Greater Glasgow and Clyde
2014-2024
University of the Cumberlands
2024
Queen Elizabeth University Hospital
2023
Public Health Scotland
2023
University of Edinburgh
2014-2023
University of Aberdeen
2023
University of Liverpool
2023
University of Glasgow
2023
Sexual Health Clinic
2022
Lothian Sexual Health
2014-2021
Abstract Long-COVID prevalence estimates vary widely and should take account of symptoms that would have occurred anyway. Here we determine the attributable to SARS-CoV-2 infection, taking background rates confounding, in a nationwide population cohort study 198,096 Scottish adults. 98,666 (49.8%) had symptomatic laboratory-confirmed infections 99,430 (50.2%) were age-, sex-, socioeconomically-matched never-infected. While 41,775 (64.5%) reported at least one symptom 6 months following this...
The objective of this study was to characterize the resurgence infectious syphilis in United Kingdom between 1997 and 2003.The authors conducted a retrospective analysis routine surveillance data from genitourinary medicine clinics collected through enhanced surveillance.Between 2002, diagnoses primary, secondary, early latent made at increased by 213% heterosexual males, 1412% men who have sex with (MSM), 22% females. These increases been driven series outbreaks, largest which were seen...
Abstract Previous studies on the natural history of long-COVID have been few and selective. Without comparison groups, disease progression cannot be differentiated from symptoms originating other causes. The Long-COVID in Scotland Study (Long-CISS) is a Scotland-wide, general population cohort adults who had laboratory-confirmed SARS-CoV-2 infection matched to PCR-negative adults. Serial, self-completed, online questionnaires collected information pre-existing health conditions current six,...
ObjectivesThe aim of this study was to analyse the trend in azithromycin susceptibility (AzDS) Neisseria gonorrhoeae Scotland between April 2004 and December 2007, characterize isolates exhibiting decreased AzDS or high-level resistance (AzHLR).
The role of a second autologous stem cell transplant (ASCT) as salvage therapy is unclear, particularly with the availability novel agents to treat progressive multiple myeloma (MM). We retrospectively reviewed all MM patients who received ASCT at our center from March 1992 December 2009. Eighty-one for relapsed MM. median time relapse after first was 39 months (9.83-100). All reinduction before ASCT. high-dose regimen given consisted melphalan (MEL) alone in majority. Complete response,...
We investigated the roles of pneumolysin and neuraminidase in pathogenesis deafness cochlear damage during experimental pneumococcal meningitis. Anesthetized guinea pigs were inoculated intracranially with 7.5 log10 CFU either (i) wild-type Streptococcus pneumoniae D39 (n = 8), (ii) PLN-A, a defined isogenic derivative deficient 5), or (iii) deltaNA1, new constructed by insertion-duplication mutagenesis nanA gene 5). To quantify hearing loss, auditory nerve compound action potential evoked...
<h3>Objective</h3> To identify risk factors for rectal lymphogranuloma venereum (rLGV) in men who have sex with (MSM). <h3>Design</h3> A case-control study at 6 UK hospitals compared MSM rLGV (cases) rLGV-negative controls: without potential symptoms (CGa) and separately, such (CGs). <h3>Methods</h3> Between 2008 2010, there were 90 cases, 74 CGa 69 CGs recruited. Lifestyles sexual behaviours the previous 3 months reported using internet-based computer-assisted self-interviews. Logistic...
The purpose of this study was to test the feasibility undertaking a full population investigation into prevalence, incidence, and persistence oral Human Papilloma Virus (HPV) in Scotland via dental settings. Male female patients aged 16-69 years were recruited by Research Nurses 3 primary care outreach teaching centres 2 General Dental Practices (GDPs), Care Teams further GDPs. Participants completed questionnaire (via an online tablet computer or paper) with socioeconomic, lifestyle, sexual...
This position statement is aimed at front-line clinical practitioners and public health authorities in WHO European Region providing services for people wishing to reduce their risk of acquiring sexually transmitted infections (STIs), including HIV.
This guideline is an update of a previous version published in 2006. In this new version, we have reflected changes the way sexual health services are now provided by adding expanded section on integrated STI/ contraception and outreach services. We also sections electronic patient records use technology history taking. The other been updated to reflect evidence practice.
<h3>Objective</h3> Since 2003, over 2000 cases of lymphogranuloma venereum (LGV) have been diagnosed in the UK men who sex with (MSM). Most present proctitis, but there are limited data on how to differentiate clinically between LGV and other pathology. We analysed clinical presentations rectal MSM identify characteristics predictive proctitis produced a prediction model. <h3>Design</h3> A prospective multicentre case–control study was conducted at six hospitals from 2008 2010. Cases were...
COVID-19 affected testing for HIV, viral hepatitis and sexually transmitted infections (STIs) worldwide. We aimed to assess the impact of pandemic on community-based voluntary, counselling (CBVCT) services those in WHO European Region.An online survey was distributed between 14 October 13 November 2020 providers Region. Key questions included: volume, reasons this impact, measures mitigate, economic effects, areas where guidance or support were needed. A descriptive analysis data reported by...
Post-autologous stem cell transplant (ASCT) studies have demonstrated that absolute lymphocyte count (ALC) recovery is associated with prolonged survival in some hematological malignancies. To assess whether ALC has prognostic significance patients multiple myeloma (MM) undergoing single ASCT, we conducted a retrospective analysis of at different time-points MM. In total 769 consecutive who underwent ASCT from January 2000 to December 2007 were evaluated. An ≥ 1400 cells/μL day 0, 15 and 90...
Abnormal vaginal discharge is a common problem which can usually be managed syndromically in non-specialist services.1 Common pathological causes include bacterial vaginosis (BV), candidiasis and Trichomoniasis (TV). Some women fail to improve with syndromic treatment, or present additional symptoms such as severe dyspareunia purulent discharge. This article focuses on practical approach investigating managing presentation specialist setting where near-patient microscopy available. It needs...
Summary Autologous stem‐cell transplant has been widely used to treat patients with AL amyloidosis. However, transplant‐related mortality rates are high, and a recent randomized trial suggested that non‐transplant regimens produced comparable results less toxicity. In order define the role of patient selection in stem cell transplantation, we evaluated 78 consecutive amyloidosis transplanted at our centre. Transplant‐related occurred 11·5%. Complete haematological response organ were...
Objectives Antibiotic resistance in gonorrhoea is of significant public health concern with the emergence to last-line therapies such as ceftriaxone. Despite around half Neisseria gonorrhoeae isolates tested UK being susceptible ciprofloxacin, very little ciprofloxacin used clinical practice. Testing for S91F mutation associated now available CE-marked assays and may reduce requirement ceftriaxone, but many patients are treated empirically, or sexual contacts, which limit any benefit. We...
To describe the sociodemographic and geographic risk factors for incident Chlamydia trachomatis genital infection.Cross sectional retrospective study of cases diagnosed in local genitourinary clinics.Coventry, West Midlands, from 1992 to 1996.582 female 620 male Coventry residents aged 15-64 years with one or more episodes infection by enzyme immunoassay. Subjects were assigned a Townsend deprivation score based on residence. The denominator population was derived 1991 census data.The mean...
Abstract Recently, the occurrence of oligoclonal and monoclonal bands (OB/MB) unrelated to original clone has been reported in patients with multiple myeloma who undergo autologous stem cell transplant (ASCT) and/or receive treatment novel agents. The aim our study was assess impact OB/MB on overall (OS) progression-free survival (PFS) for MM undergoing single ASCT at institution. All consecutive documented from January 2000 December 2012 were evaluated. Ninety-nine (11.8%) developed day 100...
Light chain deposition disease (LCDD) is a rare plasma cell dyscrasia characterized by of immunoglobulin fragments [1]. The kidneys are almost always affected, while heart, liver, and other tissues occasionally involved [2-4]. Most the patients present with nephrotic range proteinuria rapidly deteriorating renal function [5]. outcome LCDD variable. Median time to end-stage (ESRD) 2.7 years 5-year ESRD free survival 37% [3]. There no standard treatment for LCDD. Chemotherapy alkylating agents...
This guideline updates the 2010 European for management of hepatitis B and C virus infections. It is primarily intended to provide advice on testing, prevention initial viral clinicians working in sexual health clinical settings countries. The a new question answer format based situations, from which population/intervention/comparison/outcome questions were formulated. Updates cover areas such as epidemiology, point-of-care tests B, risk 'chemsex', HIV pre-exposure prophylaxis B. We have...