A5103100875- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Influenza Virus Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Rabies epidemiology and control
- Antibiotic Resistance in Bacteria
- Hepatitis B Virus Studies
- Microscopic Colitis
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Reproductive tract infections research
- Streptococcal Infections and Treatments
- Syphilis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- HIV/AIDS drug development and treatment
- Infective Endocarditis Diagnosis and Management
- SARS-CoV-2 detection and testing
- Helicobacter pylori-related gastroenterology studies
- Poxvirus research and outbreaks
- Neutropenia and Cancer Infections
- Genomics and Phylogenetic Studies
- Venomous Animal Envenomation and Studies
NHS Greater Glasgow and Clyde
2017-2024
Glasgow Royal Infirmary
2020-2024
Center for Disease Dynamics, Economics & Policy
2020
University of California, Los Angeles
2006-2016
IBM Research - Almaden
2014
Charité - Universitätsmedizin Berlin
2009
Maxygen (United States)
2009
Leipzig University
2009
SUNY Downstate Health Sciences University
2007
University of Washington
2007
Our study sought to compare the strain types of Clostridium difficile causing initial and recurrent episodes C. infection (CDI) in adult patients with a first episode CDI or 1 prior within previous 90 days. Strains originated from who had been entered into two phase 3 randomized clinical trials fidaxomicin versus vancomycin. Isolates 28 (±2) days cure were compared using restriction endonuclease analysis (REA) typing. Paired isolates available 194 (46%) CDI. Patients significantly younger (P...
There is limited information on the effect of age transmission SARS-CoV-2 infection in different settings, including primary, secondary and high schools, households, whole community. We undertook a literature review published studies/data detection contacts COVID-19 cases, as well serological studies, studies infections school setting to examine those issues. Our presents evidence for significantly lower susceptibility children aged under 10 years compared adults given same exposure,...
Antidepressants have been associated with the induction of mania and rapid cycling. This study examined whether antidepressant-associated manic states differ in any way from spontaneous mania.Forty-nine consecutive inpatients were compared 49 matched a blind, retrospective chart review.Across virtually every clinical measure examined, patients experienced milder more time-limited episodes than mania. The subject to frequent checking by nurses hall restriction for significantly shorter period...
OPT-80, a novel, minimally absorbed macrocycle, is candidate treatment option for Clostridium difficile infection (CDI) based on cure without recurrence of CDI in the hamster challenge model, good vitro activity against C. difficile, and relative sparing commensal gram-negative anaerobes. In this open-label, dose-ranging clinical trial, 48 evaluable subjects were randomized to receive either 50, 100, or 200 mg OPT-80 orally every 12 h 10 days as mild moderately severe CDI. was well tolerated...
The results of a multicenter US survey using the National Committee for Clinical Laboratory Standards currently recommended methodology measuring in vitro susceptibility 2673 isolates Bacteroides fragilis group species were compared from 1997 to 2000. test panel consisted 14 antibiotics: 3 carbapenems, β-lactam-β-lactamase inhibitors, cephamycins, 2 fluoroquinolones, clindamycin, chloramphenicol, and metronidazole. Declines geometric mean minimum inhibitory concentrations seen with imipenem,...
A total of 64 isolates Klebsiella ozaenae were recovered from 36 patients during a 40-month period. Over 7,500 K. pneumoniae isolated the same time Before this decade, was considered to be only colonizer nasopharynx or putative cause ozena (atrophic rhinitis). most frequently sputum in mixed culture but associated with infection 12 (2 bacteremia, 3 urinary tract infection, 1 soft tissue and 6 mucopurulent nasal discharge). The spectrum disease caused by organism is more extensive than has...
In 2011, we initiated a sentinel surveillance network to assess changes in Clostridioides (formerly Clostridium) difficile antimicrobial susceptibility fidaxomicin from 6 geographically dispersed medical centers the United States. This report summarizes data 2013 2016. C. isolates or toxin-positive stools patients were referred central laboratory. Antimicrobial was determined by agar dilution. CLSI, EUCAST, FDA breakpoints used, where applicable. Toxin gene profiles characterized multiplex...
In 2003, hospitals in Quebec, Canada experienced an increase of NAP1/027 Clostridium difficile infections following antibiotic administration (CDIAA). At Pierre-Le Gardeur Hospital (PLGH), the incidence increased from 10 to over 25 cases per 1000 patient admissions.We report a quasi-experimental, prospective cohort study evaluating effect on CDIAA probiotic added existing C. infection (CDI) standard preventative measures (SPM) 31,832 hospitalized patients receiving antibiotics. Phase I...
Complicated intra-abdominal infections require a combination of surgery/drainage and antimicrobial therapy that is active against both the aerobic anaerobic bacteria comprise intestinal flora. Ertapenem, parenteral carbapenem, highly resistant to wide variety beta-lactamase enzymes, has broad spectrum activity associated with community-acquired including those complicated conditions. This article reviews bacteriology infections, their susceptibility, especially anaerobes, utility animal...
We studied the comparative in vitro activity of ertapenem, a new carbapenem, against 240 aerobic and 180 anaerobic recent clinical bite isolates using an agar dilution method inoculum 10(4) cfu/spot for aerobes 10(5) anaerobes. Ertapenem inhibited 410/420 (98%) tested at < or = 4 mg/L with only 4/5 Campylobacter gracilis 1/3 rectus strains requiring . 16 inhibition. was moderately active (MIC 8 mg/L) 4/6 Enterococcus faecalis 1/11 Staphylococcus epidermidis strains. All Pasteurella...
Geographic and temporal trends in the distribution of PCR ribotypes for Clostridioides difficile associated diarrheal isolates obtained United States (US) are changing. As part a US national surveillance program C. susceptibility to fidaxomicin, we quantified stool collected from 2011 2016. or toxin + stools patients with infection (CDI) were submitted testing Tufts Medical Center 6 geographically distinct medical centers. Following isolation confirmation as difficile, approximately 35%...
Eikenella corrodens is a capnophilic gram-negative rod that part of the normal human oral flora. We report isolation E. by transtracheal aspiration or percutaneous from 7 patients with pneumonia and/or lung abscess. Four had an associated carcinoma lung. The susceptibilities strains were tested to penicillin, dicloxacillin, clindamycin, and 10 cephalosporins. All very susceptible penicillin cefoxitin resistant dicloxacillin clindamycin. Susceptibilities cephalosporins variable. has been...
The activities of BMS-284576, clinafloxacin, moxifloxacin, sitafloxacin, trovafloxacin, imipenem, cefoxitin, and clindamycin against 589 Bacteroides fragilis group isolates were determined. activity BMS-284576 was comparable to that trovafloxacin. Sitafloxacin clinafloxacin the most active quinolones, moxifloxacin least active. B. susceptible species, vulgatus resistant. Association specific antibiotic resistance with species noted for all quinolones.
Objectives Antibiotic resistance in gonorrhoea is of significant public health concern with the emergence to last-line therapies such as ceftriaxone. Despite around half Neisseria gonorrhoeae isolates tested UK being susceptible ciprofloxacin, very little ciprofloxacin used clinical practice. Testing for S91F mutation associated now available CE-marked assays and may reduce requirement ceftriaxone, but many patients are treated empirically, or sexual contacts, which limit any benefit. We...
Accurate molecular methods to detect and quantify hepatitis B virus (HBV) DNA are essential diagnose chronic infections, guide treatment decisions, assess response treatment, determine risk of HBV-related complications. New generations real-time HBV assay platforms provide results in less than 2-3 h, with continuous loading specimens true random-access capability.We examined the clinical performance new Alinity m assay, run on fully automated, continuous, platform, accurately a large series...
Genetic surveillance of seasonal influenza is largely focused on sequencing the haemagglutinin gene. Consequently, our understanding contribution remaining seven gene segments to evolution and epidemiological dynamics relatively limited. The increased availability next-generation technologies allows rapid economic whole-genome (WGS) virus. Here, 150 A(H3N2) positive clinical specimens with linked data, from 2014/15 season in Scotland, were sequenced directly using both Sanger HA1 region WGS...