A5076203151- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Dark Matter and Cosmic Phenomena
- Cosmology and Gravitation Theories
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Advanced MRI Techniques and Applications
- Radiation Therapy and Dosimetry
- Computational Physics and Python Applications
- Neutrino Physics Research
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Particle Accelerators and Free-Electron Lasers
- Atomic and Subatomic Physics Research
- Advanced NMR Techniques and Applications
- Eosinophilic Disorders and Syndromes
- Gyrotron and Vacuum Electronics Research
- Black Holes and Theoretical Physics
- Astrophysics and Cosmic Phenomena
- Flexible and Reconfigurable Manufacturing Systems
- Particle accelerators and beam dynamics
ETH Zurich
2015-2022
Carl von Ossietzky Universität Oldenburg
2014-2022
University of Wuppertal
2013-2019
The University of Adelaide
2016-2018
Northern Illinois University
2016-2018
The EndoTOFPET-US project aims to develop a multimodal detector foster the development of new biomarkers for prostate and pancreatic tumors. will consist two main components: an external plate, PET extension endoscopic ultrasound probe. plate is array LYSO crystals read out by silicon photomultipliers (SiPM) coupled Application Specific Integrated Circuit (ASIC). internal probe be highly integrated miniaturized made fully digital SiPM featuring photosensor elements readout in same chip....
Software for Tomographic Image Reconstruction (STIR) is an open-source library PET and SPECT image reconstruction, implementing iterative reconstruction as well 2D- 3D-filtered back projection. Quantitative of data requires the knowledge scanner geometry. Typical scanners, clinical pre-clinical ones, use a block-type Several rectangular blocks crystals are arranged into regular polygons. Multiple such polygons along axis. However, geometrical representation provided by STIR cylinder made...
The small animal fast insert for mRi (SAFIR) positron emission tomography was proposed quantitative dynamic acquisition inside a preclinical 7T magnetic resonance imaging scanner to study kinetics of short-lived tracers. For this purpose, the SAFIR readout should be capable handling high count rates and achieving excellent timing performance. We evaluated one available application specific integrated circuits (ASICs) SiPM readout, namely chip (STiC) version 3.1. In paper, we show...
The SAFIR collaboration is currently developing a high-rate positron emission tomography (PET) insert to study fast kinetic processes in small animals. Our designed for simultaneous image acquisition with preclinical 7 T magnetic resonance (MR) imaging device. In contrast existing PET scanners and inserts, our hardware optimized measurements source activities up 500 MBq. As first step, the Prototype was constructed. This already incorporates final components, but has reduced axial...
The proposed SAFIR PET detector will measure positron electron annihilations at injected activities up to 500 MBq in a mouse or rat. system is required have the best possible timing resolution order remove accidental coincidences (randoms) and maximise image quality for short time frames allowing possibility of 4-D kinetic modelling simultaneous MRI first time. Two different ASICs, TOFPET STiC, been investigated with LYSO crystal scintillators coupled SiPM detectors using 18F sources 480...
We present the prototype of a dedicated brain Positron Emission Tomography system BPET and results first NEMA (NU2-2018 & NU4-2008) performance evaluation. is modular system, based on PETA6SE application specific integrated circuit LYSO crystals coupled in light sharing mode to silicon photomultipliers. All electronics are into detector head, which makes ultra-compact. The NU2-2018 spatial resolution axial center [radial/tangential/axial] direction at r=10 mm [4.0 / 3.9 3.5] full width half...
SAFIR (Small Animal Fast Insert for mRi) is an innovative, high rate, PET detector insert MRI, to be used quantitative dynamic pre-clinical imaging, with very activities injected in the animals, up 500 MBq. The will designed allow ultra short acquisition periods (of order of a few seconds) simultaneously permitting unprecedented temporal resolutions preclinical multimodal imaging. High sensitivity (~ 6%), spatial resolution (~1.5 mm FWHM), excellent coincidence timing (CTR ~ 300 ps FWHM) and...
The Small Animal Fast Insert for mRi (SAFIR) will be a PET insert the Bruker BioSpin 70/30. It aims at applications where fast processes such as blood perfusion in rodent brain are to monitored comprehensively and non-invasively. Employing electronics originally designed time-of-flight applications, coincidence resolving times of less than nanosecond can achieved allowing short time windows. Consequently, random contributions events suppressed, making acquisition frames with very high tracer...
NeuroLF is a dedicated brain PET system with an octagonal prism shape housed in scanner head that can be positioned around patient's head. Because it does not have MR or CT capabilities, attenuation correction based on estimation of the map crucial feature. In this article, we demonstrate method [18F]FDG scans performed low-resolution proof concept prototype called BPET. We perform affine registration template scan to uncorrected emission image, and then apply resulting transform...
The SAFIR collaboration is developing a high rate positron emission tomography insert for preclinical 7 T magnetic resonance imaging (MRI) device. To meet the desired performance figures, large number of readout channels (≈15000) and integration data digitisation into are required. Consequently, will consume about 1.3 kW input power at low voltages (⩽ 3.3 V). This corresponds to supply currents several 100 A, requiring heavy bulky cables. overcome these problems we developed compact...
(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) 7T Magnetic Resonance Imaging (MRI) system. It designed explicitly high-rate kinetic studies in mice and rats with injected activities reaching 500MBq, enabling truly simultaneous quantitative PET (MR) imaging time frames of few seconds length. (2) Methods: SAFIR-I has an axial field view 54.2mm inner...
Software for Tomographic Image Reconstruction (STIR) is an open source C++ library used to reconstruct single photon emission tomography and positron (PET) data. STIR has experimental scanner geometry modelling feature accurately model detector placement. In this study, we test improve new using several types of data: Monte Carlo simulations measured phantom data acquired from a dedicated brain PET prototype scanner. The results show that the class applied non-cylindrical scanners improved...
Die eosinophilen Dermatosen sind eine heterogene Gruppe von seltenen Krankheiten, die histopathologisch das entscheidende Muster eines eosinophilenreichen dermalen Infiltrates vorweisen. Bei diesen können Flammenfiguren nachgewiesen werden, durch Degranulation der Eosinophilen im Gewebe entstehen. Wenngleich eosinophile Granulozyten auch bei anderen wie atopischen Dermatitis, Urtikaria, Prurigo und dem bullösen Pemphigoid etc. werden können, so ist eosinophilenreiche Infiltrat für...
Two special calorimeters are foreseen for the instrumentation of very forward region an ILC or CLIC detector; a luminometer (LumiCal) designed to measure rate low angle Bhabha scattering events with precision better than 10$^{-3}$ at and 10$^{-2}$ CLIC, polar-angle calorimeter (BeamCal). The latter will be hit by large amount beamstrahlung remnants. intensity spatial shape these depositions provide fast luminosity estimate, as well determination beam parameters. sensors this must...
Purpose: The aim of this study is the measurement lateral response function microDiamonds by comparison with radiochromic film dose measurement. In a TM60019 microDiamond (PTW Freiburg, Germany) and prototype synthetic diamond detector smaller sensitive volume were investigated. Methods: Two lead blocks positioned below gantry head an Elekta Synergy accelerator using mount. Between two sheets paper fixed. water phantom was mount, so that block to distance 20 cm. gap beam profile measured at...
A new clinical brain positron emission tomography (PET) scanner NeuroLF with octagonal detector arrangement is being finalized. Image reconstruction and data correction methods adapted for non-cylindrical geometry were recently added to the open-source Software Tomographic Reconstruction (STIR). We first evaluate performance of following NEMA NU2-2018. Second, results are compared our earlier PET system prototype BPET. Finally, newly STIR image validated. For this purpose, tests performed on...