A5018054457- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- Gut microbiota and health
- Advancements in Photolithography Techniques
- PARP inhibition in cancer therapy
- Retinal Imaging and Analysis
- Nutrition and Health in Aging
- Advanced Breast Cancer Therapies
- Retinal and Optic Conditions
- Image Enhancement Techniques
- Antioxidants, Aging, Portulaca oleracea
- Retinal Diseases and Treatments
- Genomic variations and chromosomal abnormalities
- Diet and metabolism studies
- Cancer Treatment and Pharmacology
- GABA and Rice Research
- Clostridium difficile and Clostridium perfringens research
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- Digestive system and related health
- Metaheuristic Optimization Algorithms Research
- Cardiovascular Disease and Adiposity
Anhui Polytechnic University
2024-2025
Shanghai First People's Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
Jiangsu Normal University
2025
State Key Laboratory of Food Science and Technology
2022-2024
Jiangnan University
2022-2024
Chinese Academy of Sciences
2021-2024
University of Macau
2024
Zhejiang Cancer Hospital
2021-2024
China Medical University
2023
Objective: To identify immune-related feature genes in ovarian cancer through bioinformatics analysis and perform investigations, which hold significant value for the early diagnosis prevention of cancer. Methods: Bioinformatics was utilized to The GSE18520 GSE40595 datasets were downloaded from Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/) based on gene expression comprehensive database, corresponding platform’s chip probe information retrieved. served as...
In this paper, an efficient approach to mask optimization for digital micromirror device lithography is proposed, leveraging enhanced particle swarm algorithm, which significantly elevates the resolution and precision of lithography. Initially, chaos mapping applied initial population enhance diversity, thereby improving efficiency algorithm. Subsequently, self-adaptive parameter adjustments simulated annealing are integrated effectively avoid premature convergence escape local optima....
To explore the factors influencing untimely receipt of intravitreal anti-vascular endothelial growth factor (VEGF) injections in patients with diabetic macular edema (DME), based on capability, opportunity, and motivation-behavior (COM-B) model. An exploratory qualitative study was conducted semi-structured interviews DME who had received at least one injection anti-VEGF therapy within year. The COM-B model utilized to guide both data collection analysis. Themes subthemes were identified....
Electrostatic potential (ESP) plays an essential role in studying interactions among molecules. Developing probe materials capable of selectively detecting analytes by aligning their molecular ESP with the electrostatic interaction host material is critically important for identifying analogous analytes; however, relevant research extremely lacking. In this work, we synthesized a luminescent metal-organic framework (LMOF, Cd-DBDP) featuring negative pore environments achieved incorporating...
PURPOSE The absolute cumulative risk of contralateral breast cancer (CBC) for patients with BRCA1/ 2 variants is unknown. purpose this study was to develop a CBC prediction model assessing carriers. METHODS primary cohort 491 derived from large series unselected cancer. A nomogram established on the basis results multivariate Cox regression analysis cohort. This model, named BRCA-CRisk, further validated by an independent 205 variants. Discrimination and calibration were assessed. RESULTS In...
Abstract In this paper, we propose an effective method for optimizing mask design using enhanced genetic algorithm (GA), significantly boosting digital micromirror device (DMD) maskless lithography performance. After a thorough evaluation of various optimization techniques, determined that the simulated annealing-enhanced GA (SA-GA) offers superior improvements in simulations, thus more effectively. Our findings reveal achieves up to 88% and 75% enhancement simulation accuracy circular...
Purpose: Mutations leading to homologous recombination deficiency (HRD) increase the tumor sensitivity platinum-based chemotherapy and PARP inhibitors. However, reversion mutations often develop conferring acquired drug resistance. There is still a lack of comprehensive investigation on HRR in large pan-cancer cohorts, especially Eastern Asian population. This study aims characterize repair (HRR)-related genes cohort Chinese patients. Methods: Sequencing data from 23,375 patients across over...
Lactiplantibacillus plantarum CCFM8661 alleviates D-galactose induced aging in mice.
Our study aimed to develop and validate a homologous recombination deficiency (HRD) scoring algorithm in the Chinese breast cancer population. Ninety-six in-house (BC) samples 6 HRD-positive standard cells were analyzed by whole-genome sequencing (WGS). Besides, 122 BCs from TCGA database down-sampled ~ 1X WGS. We constructed an named AcornHRD for HRD score calculated based on WGS at low coverage as input data estimate large-scale copy number alteration (LCNA) events genome. A clinical...
Abstract Background Though BRCA1 mutation is the most susceptible factor of breast cancer, its prognostic value disputable. Here in this study, we use a novel method which based on whole-genome analysis to evaluate chromosome instability (CIN) and identified potential relationship between CIN prognosis cancer patients with germline- mutation. Materials methods Sanger sequencing or 98-gene panel assay was used screen for germline small mutations 1151 high-risk factors. MLPA employed large...
Abstract Background Four Fanconi anemia (FA) genes ( BRCA1 , BRCA2, PALB2 and RAD51C ) are defined as breast cancer (BC) susceptibility genes. Other FA have been inconsistently associated with BC. Thus, the role of other in BC should be explored specific populations. Methods Mutations 16 were screened a 98-gene panel sequencing assay cohort 1481 Chinese patients high-risk hereditary The association between mutations clinicopathological characteristics well prognosis was analyzed. risk...
Reversion mutations are associated with clinical resistance to poly(ADP-ribose) polymerase inhibitors (PARPi). Here, we describe the detection of a BRCA1 reversion mutation in 39-year-old woman metastatic breast cancer harboring heterozygous germline exons 7-8 deletion who received PARPi olaparib combined immune checkpoint inhibitor camrelizumab as third-line therapy. During progression from and combination therapy, identified via genomic sequencing novel 7-base pair somatic...
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Abstract Objectives To explore factors affected untimely receiving intravitreal anti-Vascular endothelial growth factor (VEGF) injection based on the Capability, Opportunity and Motivation-Behavior (COM-B) model in patients with Diabetic Macular Edema (DME) regard these as main targets for interventions. Design An exploratory qualitative study was conducted using semi-structured interviews DME. The COM-B used to guide data collection analysis. Setting carried out outpatient department of...
Abstract Disruption of the bone metabolic balance with advancing age leads to an escalating prevalence bone‐related diseases, significantly compromising individuals’ quality life. The gut microbiota actively participates in regulation metabolism, and perturbations can exacerbate diseases by barrier integrity. Determining microbial taxa involved loss could offer valuable insights into development alternative therapies nutritional interventions for disease management. Therefore, based on...
A complex of Lactiplantibacillus plantarum CCFM8661 and chondroitin sulfate alleviates lead toxicity in lead-exposed mice.
Background: BRCA2 plays a key role in homologous recombination. However, information regarding its mutations Chinese patients with breast cancer remains limited. Objectives: This study aimed to assess the clinicopathological characteristics of mutation and explore mutation’s effect on hormone receptor (HR)-positive/human epidermal growth factor 2 (HER2)-negative survival China. Design: hospital-based cohort prospectively included 629 women diagnosed from 2008 2023 at Zhejiang Cancer Hospital...
Objective: Perianal Lesions are among the most serious complications of Crohn disease in pediatric. our objective was to analyze chinical characteristics crohn's with perianal children. And explore influencing factors disease. Methods: A retrospective analysis conducted on children, who were diagnosed Crohn's (CD) from April 2019 2023. According American gastroenterological association technical review criteria (2003 edition), they divided into two groups: lesion (PD) group (n=38) and non-...
In this paper, an efficient mask optimization method for enhanced digital micromirror device lithography quality based on improved particle swarm (PSO) is proposed, which greatly improves the of lithography. First, traditional PSO algorithm by introducing adaptive parameter adjustment to enhance its search ability in complex problems. addition, order avoid premature convergence algorithm, a simulated annealing operation introduced make it accept different solution with certain probability...