A5063496632- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Palliative Care and End-of-Life Issues
- Pharmaceutical Practices and Patient Outcomes
- Health Policy Implementation Science
- Chronic Disease Management Strategies
- Mental Health and Patient Involvement
- Health Systems, Economic Evaluations, Quality of Life
- Anesthesia and Neurotoxicity Research
- Genetics and Neurodevelopmental Disorders
- Health, Environment, Cognitive Aging
- Clinical Reasoning and Diagnostic Skills
- Technology Use by Older Adults
- Frailty in Older Adults
- Ethics in Clinical Research
- Plant and animal studies
- Cerebrovascular and genetic disorders
- Health Sciences Research and Education
- Patient-Provider Communication in Healthcare
- Patient Dignity and Privacy
- Intensive Care Unit Cognitive Disorders
- Molecular spectroscopy and chirality
- Cognitive Functions and Memory
- Liquid Crystal Research Advancements
- Cardiac, Anesthesia and Surgical Outcomes
University of Pennsylvania
1993-2025
California University of Pennsylvania
2024
University of California, Irvine
2023
Three pathologic processes are characteristic of Alzheimer disease (AD): β-amyloid, hyperphosphorylated tau, and neurodegeneration. Our understanding AD is undergoing a transformation due to our ability measure biomarkers these across different stages cognitive impairment. There growing interest in using biomarker tests care research and, with this, need for guidance on how return sensitive results patients participants. Here, we propose 5-step approach informed by clinical experience...
We investigate pathological correlates of plasma phosphorylated tau 181 (p-tau
Abstract Background Early diagnosis is crucial to the optimal management of patients with cognitive impairment due Alzheimer’s disease (AD) or AD-related dementias. For some patients, early detection enables access disease-modifying therapies. all it allows psychosocial supports. Patients typically first present their concerns about cognition a primary care provider, but in this setting, commonly underdiagnosed. There also high variability how evaluations are performed. We sought understand...
Abstract The Alzheimer’s Disease in Older Adults with Chronic Conditions (ADACC) Network is funded by the National Institute on Aging as a U24 cooperative agreement. ADACC an inclusive, multidisciplinary group across multiple institutions that charged task of developing evidence-based strategies for use and implementation disease related dementias (AD/ADRD) biomarkers among older adults cognitive impairment chronic conditions (MCCs). This report summarizes highlights First Annual Symposium...
Abstract INTRODUCTION The effect of spinal versus general anesthesia on the risk postoperative delirium or other outcomes for patients with without cognitive impairment (including dementia) is unknown. METHODS Post hoc secondary analysis a multicenter pragmatic trial comparing adults aged 50 years older undergoing hip fracture surgery. RESULTS Among randomized to anesthesia, new worsened occurred in 100/295 (33.9%) 107/283 (37.8%; odds ratio [OR] 0.85; 95% confidence interval [CI] 0.60 1.19)...
Abstract Background The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer's Disease and Related Dementia Clinical Trials (IMPACT) Collaboratory convened a Lived Experience Panel (LEP) to inform the development of research priorities provide input conducting embedded pragmatic clinical trials (ePCTs) dementia care interventions. Given importance people with lived experience research, unique considerations engaging dementia, we report our process for recruitment, selection,...
A comprehensive evaluation for cognitive impairment should culminate with the communication of diagnosis to patients and their care partners. This diagnostic disclosure sets stage subsequent care. Diagnostic individuals due Alzheimer's disease (AD) or AD-related dementias (ADRD) is particularly nuanced requires a conscientious approach. Clinicians must assess patients' understanding appreciation symptoms, goals evaluation, desire information. Because AD/ADRD can impact perceptions it...
Blood-based biomarkers (BBBMs) for Alzheimer's disease (AD) have the potential to revolutionize detection and management of cognitive impairment. AD BBBMs are not currently recommended use in primary care but may soon be as research demonstrates their clinical utility differential diagnosis patient management. To prepare incorporation into care, several practical challenges must addressed. Here, we describe four immediate challenges: (1) preparing providers order disclose BBBMs, (2)...
Abstract Universal health system-based screening for mild cognitive impairment (MCI) or consistent with dementia can modify care and increase access to disease-modifying therapies memory centers, potentially reducing disparities. Constraints on nurse clinician time have hindered existing efforts. Large language models (LLMs) present a potential solution. However, they are subject confabulation poor arithmetic accuracy, were not trained data containing definitive assessments of impairment. We...
Abstract Background Alzheimer’s disease (AD) is clinically heterogeneous, and can manifest as amnestic or non‐amnestic dementia, be pre‐manifest in persons with normal cognition (NormCog). Utility of plasma biomarkers to diagnose AD prognose cognitive decline must evaluated a heterogeneous population representative the spectrum. We investigate pathological correlates phosphorylated tau 181 (p‐tau ), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) across AD‐related...
Abstract Chiral liquid crystals exhibit molecular optical activity in the isotropic phase. We have studied evolution of as a function an applied electric field on 76·2 μm film chiral crystal W7, which exhibits isotropic–smectic A transition at approximately 40°C. measured by recording rotation plane polarization incident linearly polarized ray light, provided He–Ne laser. The biasing is parallel to direction beam. find that 41·0°C, shifts from −1·1° for voltage 30 V maximum −4·0° 70 V....