A5090306875- Bone health and treatments
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Bone Tumor Diagnosis and Treatments
- Osteoarthritis Treatment and Mechanisms
- Parathyroid Disorders and Treatments
- Medical Imaging and Pathology Studies
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Heterotopic Ossification and Related Conditions
- Topic Modeling
- Periodontal Regeneration and Treatments
- Cardiac Imaging and Diagnostics
- Tendon Structure and Treatment
- Cardiac tumors and thrombi
- Knee injuries and reconstruction techniques
- Dermatological and Skeletal Disorders
- Cleft Lip and Palate Research
- Advanced Radiotherapy Techniques
- Cerebrovascular and Carotid Artery Diseases
- Mesenchymal stem cell research
- Pressure Ulcer Prevention and Management
- Craniofacial Disorders and Treatments
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
National Institute of Dental and Craniofacial Research
2021-2024
National Institutes of Health
2021-2024
University of Missouri–Kansas City
2021-2024
National Institutes of Health Clinical Center
2021-2022
Vascular calcification causes significant morbidity and occurs frequently in diseases of calcium/phosphate imbalance. Radiolabeled sodium fluoride positron emission tomography/computed tomography has emerged as a sensitive specific method for detecting quantifying active microcalcifications. We developed novel technique to quantify map total vasculature microcalcification common space, allowing simultaneous assessment global disease burden precise tracking site-specific microcalcifications...
Abstract Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare disorder caused by deficient FGF23 signaling and resultant ectopic calcification. Here, we systematically characterized quantified macro- micro-calcification in HFTC cohort using CT 18F-sodium fluoride PET/CT (18F-NaF PET/CT). Fourier-transform infrared (FTIR) spectroscopy was performed on 4 phenotypically different calcifications from patient with HFTC, showing the dominant component to be hydroxyapatite. Eleven...
In this case report, we focus on Muenke syndrome (MS), a disease caused by the p.Pro250Arg variant in fibroblast growth factor receptor 3 (FGFR3) and characterized uni- or bilateral coronal suture synostosis, macrocephaly without craniosynostosis, dysmorphic craniofacial features, dental malocclusion. The clinical findings of MS are further complicated variable expression phenotypic traits incomplete penetrance. As such, unraveling mechanisms behind will require comprehensive systematic way...
ABSTRACT BACKGROUND Fibrous dysplasia (FD) is a rare, disabling disease with no established treatments. Growing evidence supports inhibiting the pro-osteoclastic factor receptor activator of nuclear Kappa-B ligand (RANKL) as potential treatment strategy. We conducted phase 2 trial evaluating anti-RANKL drug denosumab in adults FD, an emphasis on investigating post-discontinuation bone turnover rebound, and cellular mechanisms underlying effects FD osteoprogenitors. METHODS Eight subjects...
Stem cell therapies for degenerative cartilage disease are limited by an incomplete understanding of hyaline formation and maintenance. Human bone marrow stromal cells/skeletal stem cells (hBMSCs/SSCs) produce stable when attached to hyaluronic acid-coated fibrin microbeads (HyA-FMBs), yet the mechanism remains unclear.
In Brief: This phase 2 study investigated the effect of RANKL inhibitor denosumab on fibrous dysplasia lesion activity, as well rebound in bone turnover after treatment discontinuation.