A5100363250- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- RNA modifications and cancer
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Enhanced Recovery After Surgery
- Neuropeptides and Animal Physiology
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Cancer, Stress, Anesthesia, and Immune Response
Daping Hospital
2016-2023
Xinqiao Hospital
2023
Binzhou University
2022
Binzhou Medical University
2022
Fourth People’s Hospital of Jinan
2017-2021
The Fourth People's Hospital
2021
Baoding People's Hospital
2019
Cangzhou Central Hospital
2018
Army Medical University
2016-2017
Xi’an Children’s Hospital
2016-2017
// Jian-Jie Zhao 1 , Shuai Hao Ling-Li Wang Chun-Yan Hu Shu Zhang Ling-Ji Guo Gang Bo Gao Yan Jiang Wu-Guo Tian Dong-Lin Luo Department of Breast, Thyroid, and Vascular Surgery, Research Institute Daping Hospital, Third Military Medical University, Chongqing, 400042, P. R. China Correspondence to: Luo, email: LDL_dongDD@163.com Keywords: long non-coding RNA ANRIL, thyroid cancer, p15I NK4b TGF-β/Smad signaling pathway, TPC-1 Received: March 11, 2016 ...
Temozolomide (TMZ) is commonly used for glioma chemotherapy. However, TMZ resistance limits the therapeutic effect of in treatment. LncRNA-H19 acts as an oncogenic LncRNA some types cancers and has been reported to be up-regulated glioma.In our present study, we established TMZ-resistant cells (U-251TMZ M059JTMZ) explore H19 on chemoresistance cells.We observed that expression was significantly increased U-251TMZ M059JTMZ cells. Knockdown using specific shRNA led decreased half maximal...
Osteoarthritis (OA) is one of the most common prevalent chronic joint diseases. Emerging pieces evidence have demonstrated that chondrocytes survival was closely associated with destruction joints in OA patients. Long noncoding RNAs (lncRNAs), defined as >200 nucleotides length, also been implicated a variety disease states. However, there are few studies on role lncRNAs OA, and pathological contributions to remain largely unknown. In this study, we examined expression lncRNA UFC1 cartilage...
<i>Background:</i> MicroRNAs (miRNAs) may serve as potential diagnostic biomarkers and therapeutic targets in cardiovascular research. However, the association between miRNAs heart remodeling/reverse remodeling has not been evaluated. <i>Methods:</i> Lewis rats were divided into three groups: control animals, animals subjected to abdominal aortic constriction (AAC) those with heterotopic transplantation of (AAC-HT), respectively. The cardiomyocyte cross-sectional area...
MicroRNAs (miRNAs) play important roles in several human cancers. Although miR-188 has been suggested to function as a tumor repressor cancers, its precise role glioma and the molecular mechanism remain unknown. In present study, we investigated effect of on explored relevant mechanisms. We found that expression is dramatically downregulated tissues cell lines. Subsequent investigation revealed was inversely correlated with β-catenin tissue samples. Using luciferase reporter assay,...
The aim of the study is to explore roles microRNA (miR)-124a and miR-30d in breast cancer (BC) patients with type 2 diabetes mellitus (T2DM). A total 144 cases confirmed diagnosed BC T2DM, BC, or healthy people were enrolled. Among them, T2DM regarded as experiment group (n = 36), Dm Bc subjects 36). fasting insulin resistance index, glycosylated hemoglobin, estradiol measured. MiR-124a expressions detected by quantitative real-time polymerase chain reaction (qRT-PCR). index was...
Mutations of A‑kinase anchoring protein 2 (AKAP2) have been reported to be associated with adolescent idiopathic scoliosis. However, its role in cancer is poorly understood. In the present study, mRNA levels AKAP2 ovarian tissues were examined using qPCR. The effects on growth and migration cells crystal violet Boyden chamber assays. An vivo image system was used evaluate effect metastasis cells. study demonstrated that expression elevated cancer. Furthermore, overexpression promoted cells,...
MicroRNAs (miRs) have emerged as critical modulators of tumor initiation and progression in numerous types human cancer, including clear cell renal carcinoma (ccRCC), which is the most common subtype carcinoma. Cancerous inhibitor protein phosphatase 2A (CIP2A) a newly characterized oncoprotein its overexpression has been reported to promote cellular epithelial-mesenchymal transition ccRCC. The present study examined effects miR-218 on CIP2A expression ccRCC cells. results demonstrated that...
Purpose. To explore the expression of miR-141-3p during osteogenic differentiation human bone marrow mesenchymal stem cells (BMSCs) and its regulatory effect. Methods. Differentiation BMSCs was induced by dexamethasone. The mRNA miR-141-3p, ALP, RUNX2, OCN measured using RT-qPCR. protein detected via western blot. target predicted through TargetScan website confirmed luciferase reporter assay. Results. declined differentiation. relative ALP activities were markedly reduced in mimic group...
Objective. This study is aimed at exploring the regulatory mechanism of 73HOXC-AS1 overexpression plasmid-activated Wntβ-catenin classic signaling pathway and eukaryotic initiation factor 4A (eIF4AIII) expression increased by lentivirus-eIF4AIII-RNAi (44682-1) (LV-eIF4AIII-RNAi (44682-1)). Methods. Focusing on occurrence progression gastric cancer, human cancer cell line BGC823 (University Experimental Center) was taken as research object transfected after subculture. According to different...
Molecular residual disease (MRD) is the main cause of postoperative recurrence breast cancer. However, baseline tumor genomic characteristics and therapeutic implications cancer patients with detectable MRD after surgery are still unknown.
Abstract Previous studies reported that long noncoding RNA (lncRNA) ZFPM2‐AS1 is upregulated in renal cell carcinoma (RCC). However, the biological role of lncRNA RCC has not been explored. In this study, we investigated progression RCC. Quantitative real‐time polymerase chain reaction was used for gene expression analysis, and functional assays including Cell Counting Kit‐8 assay, flow cytometry‐based apoptosis assay transwell migration were performed to examine malignant phenotypes. The...
Objective To observe the effect of intestinal peptide on cell migration and invasion DU145 cells, explore mechanism epithelial-mesenchymal transition. Methods DU145 cells were treated with VIP at concentrations 0, 25, 50 100 μmol/L, respectively. E-cadherin, Vimentin, Snail mRNA protein detected by reverse transcriptase-polymerase chain reaction (RT-PCR) Western blotting respectively 24 h. The mobility, ability measured wound-healing assay, Transwell assays 48 h. Results With...