A5075784295- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Low-power high-performance VLSI design
- Micro and Nano Robotics
- Advancements in Semiconductor Devices and Circuit Design
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Quantum-Dot Cellular Automata
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Hematopoietic Stem Cell Transplantation
- Cellular Mechanics and Interactions
- Immune cells in cancer
- Advanced Materials and Mechanics
- Semiconductor materials and devices
- Advanced Thermodynamics and Statistical Mechanics
- Functional Brain Connectivity Studies
- Characterization and Applications of Magnetic Nanoparticles
- Microtubule and mitosis dynamics
- Neural dynamics and brain function
- Academic Writing and Publishing
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Analog and Mixed-Signal Circuit Design
Bharati Vidyapeeth Deemed University
2024
Roswell Park Comprehensive Cancer Center
2012-2023
University of Delhi
2023
Artemis Hospitals
2023
University of Pennsylvania
2020-2022
Indira Gandhi Delhi Technical University for Women
2020-2022
Christ University
2022
Aliah University
2021
The Francis Crick Institute
2018-2020
The Honourable Society of Lincoln's Inn
2020
Discrimination against racial and ethnic minority groups exists in the academy, associated biases impact hiring promotion, publication rates, grant funding, awards. Precisely how bias impacts manner which scientific community engages with ideas of academics has yet to be fully elucidated. Citations are a marker such engagement, as well currency used attain career milestones. Here we assess extent drivers imbalance reference lists papers published five top neuroscience journals over last 25...
Abstract Purpose: Treatment options are limited for patients with high-risk myelodysplastic syndrome (MDS). The azanucleosides, azacitidine and decitabine, first-line therapy MDS that induce promoter demethylation gene expression of the highly immunogenic tumor antigen NY-ESO-1. We demonstrated acute myeloid leukemia (AML) receiving decitabine exhibit induction NY-ESO-1 in circulating blasts. hypothesized vaccinating against would capitalize upon induced malignant cells to provoke an...
We aimed to determine the effect of SGI-110 on methylation and expression cancer testis antigens (CTAs) NY-ESO-1 MAGE-A in epithelial ovarian (EOC) cells vitro vivo establish impact major histocompatibility (MHC) class I Intracellular Adhesion Molecule 1 (ICAM-1) EOC cells, recognition by NY-ESO-1-specific CD8+ T-cells. also tested combined T-cells tumor growth and/or murine survival a xenograft setting. were treated with at various concentrations as xenografts 3 distinct dose schedules....
// Pragya Srivastava 1 , Benjamin E. Paluch 2 Junko Matsuzaki 3 Smitha R. James Golda Collamat-Lai Nadja Blagitko-Dorfs 4 Laurie Ann Ford Rafeh Naqash Michael Lübbert Adam Karpf 5 J. Nemeth 1,6 and Elizabeth A. Griffiths 1,2,6 Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA Pharmacology Therapeutics, Center for Immunotherapy, Division Hematology/Oncology, University Freiburg, Medical Center, Germany Eppley Institute Research, Fred Pamela Buffet Nebraska Omaha,...
Significance Living systems differ from dead matter in one crucial aspect: They are driven by internal engines. In anisotropic fluids, the widely accepted framework of active theory predicts that this necessarily leads to an instability quiescence large-scale and eventually incoherent motion. Here we challenge common wisdom reexamining symmetries most ubiquitous experimental geometry for systems. We uncover additional coupling between activity motion can make system even more stable than its...
Activity softens the stiffness of active nematics on a frictional substrate, yielding modulated phases and turbulence.
Azadirachta indica, commonly known as neem, has a wide range of medicinal properties. Neem extracts and its purified products have been examined for induction apoptosis in multiple cancer cell types; however, underlying mechanisms remain undefined. We show that neem oil (i.e., neem), which contains majority limonoids including azadirachtin, induced apoptotic autophagic death. Gene silencing demonstrated caspase cascade was initiated by the activation caspase-9, whereas caspase-8 also...
We present a general dynamical theory of membrane coupled to an actin cortex containing polymerizing filaments with active stresses and currents, demonstrate that dynamics [Phys. Rev. Lett \textbf{84}, 3494 (2000)] spontaneous shape oscillations emerge from this description. also consider instabilities patterns induced by the presence polar orientational correlations in tangent plane membrane. The features we predict should be seen variety cellular contexts involving membrane-cytoskeleton...
Recent advances in computational models of signal propagation and routing the human brain have underscored critical role white matter structure. A complementary approach has utilized framework network control theory to better understand how constrains manner which a region or set regions can direct activity other regions. Despite potential for both these approaches enhance our understanding structure function, little work sought relations between them. Here, we seek explicitly bridge...
We present a comprehensive theory of the dynamics and fluctuations two-dimensional suspension polar active particles in an incompressible fluid confined to substrate. show that, depending on sign single parameter, state with orientational order is anomalously stable (or unstable), nonzero relaxation growth) rate for angular at zero wavenumber. This screening broken-symmetry mode does lead conventional rather than giant number as argued by Bricard et al., Nature ${\bf 503}$, 95 (2013), but...
Abstract Background Global regulatory mechanisms involving chromatin assembly and remodelling in the promoter regions of genes is implicated eukaryotic transcription control especially for subjected to spatial temporal regulation. The potential utilise global controlling gene expression might depend upon architecture around gene. In-silico analysis can yield important insights into this aspect, facilitating comparison two or more classes comprising a large number within each group. Results...
Successful cytokinesis requires proper assembly of the contractile actomyosin ring, its stable positioning on cell surface and constriction. Over years, many key molecular components regulators ring have been elucidated. Here we show that geometry mechanics play a crucial role in uniform constriction ring. Contractile rings assemble spherical end caps fission yeast cells normal morphology or are unstable slip towards poles. On other hand, locally cylindrical portions under same conditions do...
Proliferating animal cells are able to orient their mitotic spindles along interphase cell axis, setting up the axis of division, despite rounding as they enter mitosis. This has previously been attributed molecular memory and, more specifically, maintenance adhesions and retraction fibers in mitosis [1Théry M. Jiménez-Dalmaroni A. Racine V. Bornens Jülicher F. Experimental theoretical study spindle orientation.Nature. 2007; 447: 493-496Crossref PubMed Scopus (320) Google Scholar, 2Fink J....
Signal propagation along the structural connectome of brain induces changes in patterns activity. These activity define global states and contain information accordance with their expected probability occurrence. The connectome, conjunction dynamics, determines set possible constrains transition between accessible states. Yet, precisely how these constraints on state-transitions relate to content remains unexplored. To address this gap knowledge, we defined as a function activation...
Large Language Models (LLMs), excel in natural language understanding, but their capability for complex mathematical reasoning with an amalgamation of structured tables and unstructured text is uncertain. This study explores LLMs' on four financial tabular question-answering datasets: TATQA, FinQA, ConvFinQA, Multihiertt. Through extensive experiments various models prompting techniques, we assess how LLMs adapt to tasks. We focus sensitivity table complexity performance variations...