A5069967041- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Nonmelanoma Skin Cancer Studies
- Autoimmune Bullous Skin Diseases
- Contact Dermatitis and Allergies
- Nail Diseases and Treatments
- Cancer and Skin Lesions
- Acne and Rosacea Treatments and Effects
- Autoimmune and Inflammatory Disorders
- Urticaria and Related Conditions
- Hedgehog Signaling Pathway Studies
- Dermatological diseases and infestations
- Allergic Rhinitis and Sensitization
- Pharmaceutical studies and practices
- Photodynamic Therapy Research Studies
- Asthma and respiratory diseases
- Infectious Diseases and Mycology
- melanin and skin pigmentation
- Oral Health Pathology and Treatment
- Cutaneous lymphoproliferative disorders research
- Genetic and rare skin diseases.
- Medicine and Dermatology Studies History
- Skin Protection and Aging
- Skin Diseases and Diabetes
- Cutaneous Melanoma Detection and Management
Fremantle Hospital
2015-2025
The University of Western Australia
2016-2025
Probity Medical Research
2021-2024
Goethe University Frankfurt
2018
The University of Melbourne
2009
Skin and Cancer Foundation
2009
St George Hospital
2009
Liverpool Hospital
2009
Royal Prince Alfred Hospital
2009
Princess Alexandra Hospital
2009
SUMMARY The sap of the plant Euphorbia peplus is a traditional remedy for skin conditions, including actinic keratosis. active constituent ingenol mebutate (ingenol‐3‐angelate), formerly known as PEP005. This randomized, double‐blind, vehicle‐controlled, phase IIa study investigated safety (and secondarily efficacy) two applications gel in 58 patients with biopsy‐confirmed Five preselected lesions were treated gel, 0.0025%, 0.01% or 0.05%, vehicle on days 1 and 2 (Arm A) 8 B). There no...
Background Basal cell carcinoma (BCC) may be difficult to treat by conventional means, particularly if the lesions are large or located in mid‐face (H‐zone). Photodynamic therapy (PDT) using topical methyl aminolaevulinate (MAL) a good noninvasive option for these patients. Objectives To investigate efficacy and safety of PDT MAL BCCs defined as 'difficult treat', i.e. lesions, H‐zone, patients at high risk surgical complications. Methods This was prospective, multicentre, noncomparative...
From a total of 993 previously reported cases occupational skin disease (OSD), 954 (96%) were contacted and 711 (75%) examined, The review time (i.e., period from original diagnosis OSD until review] varied u minimum 6 months to maximum over 8 years. Over 60% reviewed more than 2 years after the was made. More 50% still suffering or consequences related thereto. Clearance less likely in those who remained their original, similar, environment. However, changed job due OSD. Many suffered...
Abstract Background Data suggest that photodynamic therapy using topical methyl aminolevulinate (MAL PDT) may be a noninvasive alternative to excisional surgery for nodular basal cell carcinoma (BCC). In the studies described here, we investigated histologic response, tolerability, and cosmetic outcome with MAL PDT primary BCC (≤ 5 mm in depth). Methods Two multicenter, randomized, double‐blind similar design procedures were conducted. After surface debridement minor tumor debulking, cream...
SUMMARY This randomized, double‐blind, placebo‐controlled study assessed the efficacy and safety of a topical gel containing 3% diclofenac in 2.5% hyaluronan 150 patients with solar keratoses (SK). The active treatment was compared vehicle only, gel, as placebo over 12‐week period. Patients both groups applied or to targeted area skin (0.25 g b.d.). At 12 weeks mean lesion‐count reduction not significantly different between treatments. However, at post‐termination follow up (16 weeks), there...
To elucidate Further the natural history and prognosis of occupational chromate dermatitis, 120 affected patients, diagnosed between 1980 1989, were reviewed. The incidence dermatitis in Western Australia appeared to remain unchanged over decade, 65% patients construction workers with cement‐induced Workers at greatest risk sensitization those mixing bagged cement work site. median age onset symptoms was 34 years, 48% having been exposed for 5 years or less. Only 37% presented dermatologist...
993 cases of occupational skin disease (OSD) were diagnosed in a private dermatology practice over an 8–year period. Dermatologists wore the major source referral. The sex ratio was 2.4 males to 1 female. Patch tests conducted 79% cases. Wet work industries predominated females; causative more varied. Apprentices affected high proportion pf hairdressers and food handlers. Atopics accounted for 75% apprentice hairdressers. also prevalent females with OSD than males. 29% all eases had suffered...
Clinical studies in cutaneous conditions other than actinic keratosis (AK) have revealed that the safety and efficacy profile of imiquimod is influenced by dosing frequency.To evaluate frequency response 5% for treatment AK.This was a phase II, multicentre, randomized, double-blind, placebo-controlled study. Adults with > or = 10 but < 50 clinical AKs, one which histologically confirmed, were randomized (4:1) to 2-6 packets placebo cream applied dorsum forearms hands once daily 2, 3, 5 7...
Psoriasis, a chronic inflammatory skin disease marked by hyper proliferation and aberrant differentiation of keratinocytes, affects 2-3% the world's population. Research into pathogenesis psoriasis has been hampered lack models that accurately reflect biology psoriatic phenotype. We have previously reported East Indian Sandalwood oil (EISO) significant anti-inflammatory properties in hypothesized EISO might provide therapeutic benefit to patients due its anti-proliferative properties. Here...
Importance A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because affordable globally available, uniform could potentially optimize the treatment of patients with worldwide. Objective To reach international consensus among experts on adult pediatric identify potential future research topics. Design, Setting, Participants Between September 2020 March 2021, survey study modified eDelphi procedure that was developed distributed by...
Background Scalp psoriasis is common and difficult to treat. Objective To evaluate efficacy safety of tildrakizumab for the treatment scalp psoriasis. Methods In this Phase 3b, randomized, double-blind, placebo-controlled study (NCT03897088), patients with moderate-to-severe plaque affecting (Investigator Global Assessment modified [IGA mod] 2011 [scalp] ≥3, Psoriasis Severity Index [PSSI] ≥12, ≥30% surface area affected) received 100 mg or placebo at W0 W4. The primary endpoint was IGA mod...
Purpose Guselkumab, an interleukin (IL)-23 inhibitor, effectively treats moderate-to-severe plaque psoriasis.Materials and methods ECLIPSE, was a Phase 3, multicenter, 56-week, double-blinded, active-comparator study of guselkumab vs. secukinumab (IL-17A inhibitor) in patients with psoriasis. Patients were treated 100 mg (n = 534) or 300 514) through week 44. Efficacy (at least 90% 100% improvement from baseline Psoriasis Area Severity Index [PASI 90 PASI 100], Investigator's Global...
Imiquimod 5% cream is approved in the USA, Europe and Australia to treat superficial basal cell carcinoma, using a regimen of once daily, 5 times per week for 6 weeks. Vehicle-controlled, phase III clinical trials show that imiquimod safe effective treating carcinoma with dosing or 7 This III, open-label study evaluates long-term (5 years) efficacy safety which this manuscript reports 2-year time point follow-up period. For 169 enrolled subjects, tumour selected treatment was assessed...
Concern exists that the prolonged application of immunomodulators to treat atopic dermatitis may cause systemic immunosuppression.In a 7-month, multicentre, randomised, controlled trial, we investigated equivalence response vaccination against meningococcal serogroup C disease with protein-conjugate vaccine in children (2-11 years) moderate severe dermatitis, by applying either 0.03% tacrolimus ointment (TAC-O; n = 121[corrected]) or hydrocortisone regimen (HC-O; 111).TAC-O was applied twice...
ABSTRACT A 44‐year‐old woman was diagnosed with Graves' disease in 1995 and over the following 12 months developed thyroid dermopathy (pretibial myxoedema). Despite being trialled on multiple recognized therapies course of 11 years, patient's progressively worsened. She ocular proptosis, elephantiasic acropachy both hands. In mid 2006, patient started rituximab plasmapheresis, rapid response. The condition stabilized October 2009 at age 58 years she able to cease therapy.