A5025182961- Reproductive tract infections research
- Polyamine Metabolism and Applications
- Parasitic Infections and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- Free Radicals and Antioxidants
- Amoebic Infections and Treatments
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Carcinogens and Genotoxicity Assessment
- Sulfur Compounds in Biology
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
- Tuberculosis Research and Epidemiology
- Plant Toxicity and Pharmacological Properties
- Bacteriophages and microbial interactions
- Skin and Cellular Biology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Climate change and permafrost
- Effects and risks of endocrine disrupting chemicals
- Nephrotoxicity and Medicinal Plants
- Biliary and Gastrointestinal Fistulas
- Ion channel regulation and function
- Ovarian cancer diagnosis and treatment
Universidad Autónoma de la Ciudad de México
2011-2025
El Colegio Mexiquense
2018-2023
Universidad Nacional Autónoma de México
2015
Center for Research and Advanced Studies of the National Polytechnic Institute
2004-2008
La capacidad de medir o evaluar el pronóstico una enfermedad y, en consecuencia, orientar tratamiento es posible gracias al desarrollo indicadores biológicos, denominados manera general biomarcadores. Las empresas del área la salud utilizan ampliamente este tipo biomoléculas para exposición, eficacia y seguridad los fármacos, así como mejorar diseño ensayos clínicos selección pacientes. Los biomarcadores también ayudan a dosificación determinar cuándo acelerar un fármaco, por lo que...
Abstract Icaritin is a natural prenylated flavonoid derived from the Chinese herb Epimedium. The compound has shown antitumor effects in various cancers, especially hepatocellular carcinoma (HCC). exerts its anticancer activity by modulating multiple signaling pathways, such as IL‐6/JAK/STAT3, ER‐α36, and NF‐κB, affecting tumor microenvironment immune system. Several clinical trials have evaluated safety efficacy of icaritin advanced HCC patients with poor prognoses, who are unsuitable for...
Cancer treatment typically involves multiple strategies, such as surgery, radiotherapy, and chemotherapy, to remove tumors. However, chemotherapy often causes side effects, there is a constant search for new drugs alleviate them. Natural compounds are promising alternative this problem. Indole-3-carbinol (I3C) natural antioxidant agent that has been studied potential cancer treatment. I3C an agonist of the aryl hydrocarbon receptor (AhR), transcription factor plays role in expression genes...
EhCP112 is an Entamoeba histolytica protease that together with the EhADH112 protein forms EhCPADH complex involved in trophozoite virulence. Here, we produced recombinant and studied its relationships extracellular matrix components target cells. A DNA fragment containing pro-peptide mature enzyme was expressed bacteria as active (rEhCP112), whereas full gene signal peptide, a non-active protein. The only not expressed. rEhCP112 purified by affinity columns digested azocasein had strong...
Trichomonas vaginalis, a human urogenital tract parasite, is capable of surviving in the male microenvironment, despite presence Zn(2+). Concentrations > 1.6 mM Zn(2+) have trichomonacidal effect; however, ≤1.6 Zn(2+), several trichomonad proteins are up- or down-regulated. Herein, we analyzed proteome T. vaginalis isolate (HGMN01) grown and found 32 protein spots that were immunorecognized by trichomoniasis patient serum. Using mass spectrometry (MS), identified compared with 23 female...
Our investigation focused on the study of proteome, morphology, and cytotoxicity T. vaginalis during interactions with prostatic DU-145 cells. The results suggest that approximately 37 different proteins are expressed in presence Zn 2+ , which also down-regulates protein transcriptional levels TvCP65. result is a negative effect trichomonal cytotoxicity. differentially were identified by mass spectrometry analysis.
N-aryl maleimides can undergo a 1,4-Michael-type addition reaction with reduced glutathione (GSH), leading to decreased concentration of GSH and an increased free radicals (FRs) in cells. is critical scavenging molecule responsible for protecting cells from oxidation maintaining redox homeostasis. disturb homeostasis because they scavenge thiol-containing molecules, especially GSH. This study aimed at measuring the concentrations FRs by electronic paramagnetic resonance (EPR), brain liver...
Lithium, a natural element, has been employed as mental stabilizer in psychiatric treatments; however, some reports indicate it an anticancer effect, prompting the consideration of repurposing lithium for cancer treatment. The potential use may depend on its form (salt type) and type cells targeted. Little is known about effects Li2CO3 or LiCl cells, so we focused exploring their proliferation, apoptosis, migration, cell cycle part hallmarks cancer. Firstly, established IC50 values HeLa,...
Polyamines are involved in the regulation of some Trichomonas vaginalis virulence factors such as transcript, proteolytic activity, and cytotoxicity TvCP65, a cysteine proteinase (CP) trichomonal cytotoxicity. In this work, we reported putrescine effect on TvCP39, other CP that also participate Parasites treated with 1,4-diamino-2-butanone (DAB) (an inhibitor biosynthesis), diminished amount activity TvCP39 compared untreated parasites. Inhibition biosynthesis reduced ∼80% tvcp39 mRNA levels...
Mycobacterium bovis has a wide range of hosts. Usually, it affects cattle; however, been detected in humans and many wildlife reservoirs such as cervids, badgers, feral pigs, brushtail possums, buffaloes. Persistence made difficult to eradicate M. bovis, even developed countries. The main route transmission is by aerosol through the respiratory tract; direct contact between cattle explanation for species. However, depopulated farms have experienced recontamination after cleaning disinfecting...
Several factors contribute to the increase in breast cancer (BC) incidence, such as lifetime exposure estrogen, early menarche and older ages at first birth, menopause, increased prevalence of postmenopausal obesity. In fact, there is an association between BC risk elevated estrogen levels, which may be involved carcinogenesis via receptor alpha (ERα) encoded by ESR1 gene. Interestingly, antagonistic relationship ERα aryl hydrocarbon (AhR) cells.Herein, we explore combined effects (XbaI,...
Abstract Background The ESR 1 gene suffers methylation changes in many types of cancers, including breast cancer (BC), the most frequently diagnosed women that is also present men. Methylation at promoter A worse prognosis terms overall survival; thus, early detection, prognostic, and prediction therapy involve some biomarkers. Methods Therefore, our study aimed to examine levels samples from Mexican BC patients its possible association with menopausal status. Results We identified a novel...
Protein phosphorylation is a posttranslational modification that essential for normal cellular processes; however, abnormal one of the prime causes alteration many structural, functional, and regulatory proteins in disease conditions. In cancer, changes states protein tyrosine residues have been more studied than threonine or serine residues, which also undergo alterations with greater predominance. general, leads to formation multimolecular signaling complexes regulate diverse biological...