A5065905988- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Synthesis and Reactivity of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Click Chemistry and Applications
- Tuberculosis Research and Epidemiology
- Free Radicals and Antioxidants
- Computational Drug Discovery Methods
- Ferrocene Chemistry and Applications
- Mesoporous Materials and Catalysis
- Adenosine and Purinergic Signaling
- Biochemical and Molecular Research
- Metal complexes synthesis and properties
- Carbohydrate Chemistry and Synthesis
- Multicomponent Synthesis of Heterocycles
- Electrocatalysts for Energy Conversion
- Problem and Project Based Learning
- HIV/AIDS drug development and treatment
- Porphyrin and Phthalocyanine Chemistry
- Engineering Education and Curriculum Development
- Chemical Synthesis and Analysis
- Biomedical and Engineering Education
- Mycobacterium research and diagnosis
University of Minho
2014-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
University of Coimbra
2009-2022
Universidade Estadual de Campinas (UNICAMP)
2019
University Clinic of Traumatology
2009
Universidade de Santo Amaro
2009
University of Brescia
2009
Pennsylvania State University
2004
University of Manchester
1995
SUNY Plattsburgh
1973
Project-Based Learning (PBL) has been implemented in the first year of Industrial Engineering and Management programme at University Minho, Portugal, since 2004/2005. The purpose this paper is to analyse discuss teachers' experiences PBL explore its implications for student learning teaching practices higher education. For data collection, research method used was written narratives these teachers, end semester. Findings suggest that teachers express a positive view as approach. They...
Abstract Tuberculosis (TB) is an infectious disease which affects millions of people worldwide. Inhalable polymeric dry powders are promising alternatives as anti‐TB drug carriers to the alveoli milieu and infected macrophages, with potential significantly improve therapeutics efficiency. Here, development a magnetically responsive microparticulate system for pulmonary delivery candidate (P3) reported. Microparticles (MPs) developed based on cast method using calcium carbonate sacrificial...
Buruli ulcer, caused by Mycobacterium ulcerans infections, is a necrotizing skin disease whose pathogenesis associated with the exotoxin mycolactone. Despite relevance of this emergent disease, little known on immune response against pathogen. Following recent demonstration an intramacrophage growth phase for M. ulcerans, we investigated biological IFN-gamma and antimycobacterial mechanisms activated cytokine in ulcerans-infected macrophages. Three strains were tested: 5114 (mutant...
Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans. The tissue damage characteristic of BU lesions known to be driven the secretion potent lipidic exotoxin mycolactone. However, molecular action mycolactone on host cell biology mediating cytopathogenesis not fully understood. Here we applied two-dimensional electrophoresis (2-DE) identify mechanisms mycolactone's cellular in L929 mouse fibroblast proteome. This revealed 20 changed spots corresponding 18...
Purpose: Project-Based Learning (PBL) is considered to be an active learning methodology which can used develop both technical and transversal competences in engineering programs. This demands a great deal of work effort from the students also teachers it requires meticulous plan well-managed project as well. These activities go far beyond normal traditional lectures, enabling outpace difficulties that spur along way may complex demotivating. has been implemented Integrated Master Degree on...
Abstract ( Z )‐ N 1 ‐(2‐Amino‐1,2‐dicyanovinyl)‐ 2 ‐substituted‐formainidines react with dimethylformamide diethyl acetal at room temperature to give 6‐cyanopurines as the major product together novel 5‐amino‐2‐arylimino‐3,4‐di[( N,N ‐dimethylamino)methylideneamino]‐2 H ‐pyrroles, which have been fully characterised and a single crystal X‐ray analysis has carried out on ‐phenyl derivative.
An encapsulated Mn(III)– salen complex in NaY was synthesized and characterized, the catalytic behaviour of evaluated by oxidation styrene. The encapsulation achieved two different methodologies designated as flexible ligand method (A) situ synthesis (B). characterizations free well catalysts with without were performed powder X‐ray diffraction, scanning electron microscopy, chemical analysis FT‐IR spectroscopy. Both prepared are active styrene presence tert ‐butyl hydroperoxide ( t BuOOH)...
6-Cyano-9-substituted-9H-purines were prepared in a high yielding, one-step process by refluxing triethyl orthoformate or orthopropionate with the corresponding (Z)-N1-(aryl- benzyl)-N2-(2-amino-1,2-dicyanovinyl)formamidines. Attempted reaction of these cyanopurines aqueous methylamine furnished 8-(arylamino)-4-imino-3-methylpyrimidino[5,4-d]pyrimidines, attack at imidazole ring rather than addition to 6-cyano group. All compounds have been fully characterised spectroscopic data and an X-ray...
Abstract 7,8‐Dihydropyrimido[5,4‐ d ]pyrimidines 4 were isolated in very good yields by treatment of 9‐aryl‐6‐cyanopurines 1 with primary amines. Nucleophilic attack the amine on C8 purine ring was followed ring‐opening imidazole unit, and subsequent intramolecular cyclization involving newly formed amidine group cyano substituent pyrimidine produced 7,8‐dihydropyrimido[5,4‐ ]pyrimidine structure . When ammonia used instead amines, compound rapidly reacted further to afford more stable...
Abstract Y‐encapsulated Cu II –purine complexes were synthesized, characterized and studied in the catalytic oxidation of cyclohexene. Encapsulation was achieved by ion‐exchanging complex from aqueous solutions containing both purine ligand, 9‐methyl‐6‐(methylamino)purine, copper, different pH, with a purine/Cu molar ratio 5:1. The resulting materials surface analysis (XPS, SEM XRD), chemical analysis, spectroscopic methods (EPR, FTIR UV/Vis) thermal (TGA), which indicated that effectively...
Abstract N , N‐ Dialkyladenine derivatives were prepared by two different reaction sequences starting from 5‐amino‐4‐cyanoformimidoylimidazoles. When these imidazoles treated with dimethylformamide diethyl acetal, a 5‐aminomethyleneamino‐4‐cyanoformimidoylimidazole was isolated and evolved to the dialkyladenine in presence of secondary alkylamine. The same purine structure when 5‐amino‐4‐cyanoformimidoylimidazole first amine give stable 4‐amidino‐5‐aminoimidazole. desired product generated...
Abstract The oxidation of phenol, cychohexanol and hydroquinone has been screened in the presence copper(II) complexes with Schiff‐base salen ligand, 1,5‐bis[( E )‐5‐chloro‐2‐hydroxybenzylideneamino]‐1 H ‐imidazole‐4‐carbonitrile, encapsulated into NaY zeolite by using two different methods. new heterogeneous catalysts were characterized SEM, XRD, FTIR, EPR Raman spectroscopy as well chemical analysis. structures proposed on basis theoretical studies (DFT). catalytic activities compared...
Paper aims This paper presents teachers and students perspectives of integration Science, Technology, Engineering Mathematics (STEM) courses contents into the first year Industrial Management (IEM) program through Project-Based Learning (PBL). Originality These provide strategies that IEM could use to challenge apply STEM design a product its production system by developing semester interdisciplinary project. Research method Grounded on project deliveries an on-line questionnaire, students’...
A set of new derivatives 4,8-disubstituted pyrimido[5,4-
Two different approaches have been used for the synthesis of 6-enaminopurines 6 from 5-amino-4-cyanoformimidoyl imidazoles 1. In first approach 1 were reacted with ethoxymethylenemalononitrile or ethoxymethylenecyanoacetate under mild experimental conditions and this led to 9-substituted-6-(1-amino-2,2-dicyanovinyl) purines 6a–f 9-substituted-6-(1-amino-2-cyano-2-methoxycarbonylvinyl) 6g–k. These reactions are postulated occur through an imidazo-pyrrolidine intermediate 7, which rapidly...
Abstract The reaction of benzylhydroxylamine with 6‐cyanopurines leads to the formation 7‐benzyloxy‐8‐imino‐7,8‐dihydropyrimido[5,4‐ d ]pyrimidines. hydrochloride these compounds, isolated upon addition aqueous hydrochloric acid, is a convenient precursor pyrimido[5,4‐ ]pyrimidine N ‐oxides when suspension salt refluxed in ethanol or acetonitrile. Refluxing solution same ethanol, Dimroth‐rearranged product.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Sleeping sickness and leishmaniasis are neglected tropical diseases that threaten millions of people. The currently available therapies present several limitations, including high toxicity, lack efficacy, emerging drug resistance, prompting a search for novel therapeutic agents. In this work, we designed, synthesized, in vitro evaluated the activity new pyrimido[5,4-d]pyrimidines against Trypanosoma brucei Leishmania infantum (promastigote amastigote forms). cytotoxicity compounds THP1 cell...