A5034832639- Viral Infections and Vectors
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- Dental Implant Techniques and Outcomes
- Viral gastroenteritis research and epidemiology
- Parasitic Diseases Research and Treatment
- Prostate Cancer Treatment and Research
- Dental Radiography and Imaging
- Animal Virus Infections Studies
- Parasite Biology and Host Interactions
- Prostate Cancer Diagnosis and Treatment
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Tracheal and airway disorders
- Drug Transport and Resistance Mechanisms
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Periodontal Regeneration and Treatments
- Bat Biology and Ecology Studies
- Spine and Intervertebral Disc Pathology
- vaccines and immunoinformatics approaches
- Plant Virus Research Studies
- Dermatological diseases and infestations
- Dental materials and restorations
Washington University in St. Louis
2023-2025
Friedrich-Loeffler-Institut
2015-2024
Institut Pasteur du Laos
2024
Institut de Recherche Agronomique de Guinée
2024
University of Southern Denmark
2024
Institut Pasteur
2024
University of Castilla-La Mancha
2024
Consejo Superior de Investigaciones Científicas
2024
University of Córdoba
2024
Bayer (Germany)
2019-2023
Sirtuin 6 (SIRT6) is a member of the sirtuin family NAD+-dependent deacetylases. Genetic deletion Sirt6 in mice results severe degenerative phenotype with impaired liver function and premature death. The role SIRT6 development progression hepatocellular carcinoma currently unknown. We first investigated expression 153 primary human cancers normal cirrhotic livers using microarray analysis. was significantly down-regulated both cancer. A knockout (KO) gene signature generated from hepatoctyes...
ABSTRACT Background: There have been very few long‐term controlled studies (i.e., over 5 years duration) focusing on marginal conditions for implants with a sandblasted, large grit, and acid‐etched (SLA) surface. Purpose: To evaluate report 10‐year data outcomes of an SLA surface placed in the edentulous maxilla. Materials Methods: In randomized trial (RCT) cohort 24 patients, were registered. The RCT has previously reported after 1 year, 3 years, loading. Results: One patient dropped out...
Abstract Objectives: The overall aim was to compare the clinical outcomes of early and delayed implant loading in totally edentulous maxilla during 5 years function. Materials methods: Twenty‐four patients with maxillae were randomized two groups subjected (test, n =16) or (control, =8) loading. A total 142 implants placed 139 (Straumann AG) loaded full‐arch bridges followed for years. Results: All received maintained a fixed bridge throughout study period. Five (5.3%) test three (4.3%)...
ABSTRACT Background: The use of immediate/early implant loading protocols offers obvious advantages for the patient. Although well documented in totally edentulous mandible, information about clinical outcomes from such partially edentate maxilla is lacking. Purpose: present study was conducted to clinically and radiographically evaluate a tapered design with an oxidized surface maxilla. aim also correlate stability measurements using resonance frequency analysis (RFA) diameter length, bone...
ABSTRACT Background: Long‐term follow‐up studies (i.e., over 5 years), focusing on prosthetic outcomes and maintenance of implant‐supported reconstructions in the edentulous maxilla, are scarce literature. Purpose: The purpose this study was to evaluate report 10‐year data screw‐retained full‐arch casted titanium‐resin prostheses maxilla. Materials Methods: In randomized control trial cohort 24 patients, outcome 23 bridges were registered. Results: One patient dropped out prior control. Of...
The transcription factor Sox10 regulates early neural crest development,specification of crest-derived lineages and terminal differentiation oligodendrocytes in the central nervous system. Here, we generated two novel hypomorphic alleles mouse. Mutant mice either expressed a protein with triple alanine substitution dimerization domain,or deletion portion that define as cell-specific transactivation domain. Phenotypic analysis revealed important roles for functional domain newly defined...
Inherited erythromelalgia (IEM) causes debilitating episodic neuropathic pain characterized by burning in the extremities. “paroxysmal extreme disorder” (PEPD) differs its clinical picture and affects proximal body areas like rectal, ocular, or jaw regions. Both syndromes have been linked to mutations voltage-gated sodium channel Nav1.7. Electrophysiological characterization shows that IEM-causing generally enhance activation, whereas leading PEPD alter fast inactivation. Previously, an...
We conducted a cross-sectional study in wild boar and extensively managed Iberian pig populations hotspot area of Crimean-Congo hemorrhagic fever virus (CCHFV) Spain. tested for antibodies against CCHFV by using 2 ELISAs parallel. assessed the presence RNA means reverse transcription quantitative PCR protocol, which detects all genotypes. A total 113 (21.8%) 518 suids sampled showed ELISA. By species, 106 (39.7%) 267 boars 7 (2.8%) 251 pigs analyzed were seropositive. Of 231 analyzed, none...
Onchocerca volvulus is the agent of onchocerciasis (river blindness) and targeted by WHO for elimination though mass drug administration with ivermectin. A small percentage adult female worms develop pleomorphic neoplasms (PN) which occur more frequently after ivermectin treatment. Worms PN have a lower life expectancy improved understanding proteins expressed in their impact on different tissues could help elucidate mechanisms macrofilaricidal activity Within paraffin embedded nodules...
Hendra virus (HeV) and Nipah (NiV) belong to the genus Henipavirus in family Paramyxoviridae. infections were first reported 1990's causing severe often fatal outbreaks domestic animals humans Southeast Asia Australia. NiV observed Bangladesh, India outbreak Malaysia, where pigs also infected. HeV occurred horses North-Eastern regions of Australia, with singular transmission events humans. Bats Pteropus have been identified as reservoir hosts for henipaviruses. Molecular serological...
Abstract The effects of hypnosis in connection with surgery have been described many clinical publications, but few controlled studies published. aim the present study was to evaluate preoperative hypnotic techniques used by patients planned for surgical removal third mandibular molars. were randomly assigned an experimental (hypnotic techniques) or a control (no group. During week before surgery, group listened audiotape containing relaxation induction. Posthypnotic suggestions healing and...
3007 Background: The ATR kinase is a key regulator of the DNA damage response (DDR) machinery, activated by and replication stress. BAY 1895344 novel, potent, selective inhibitor with anti-tumor activity in preclinical models DDR defects. Methods: Pts advanced metastatic solid tumors resistant or refractory to standard treatment, without defects, received BID, 3 days (d) on/4 d off continuously 3-weekly cycles. Results: As December 20, 2018, 18 pts colorectal (4), breast (3), prostate (2),...
The non-vitamin K antagonist oral anticoagulant rivaroxaban is used in several thromboembolic disorders. Rivaroxaban eliminated via both metabolic degradation and renal elimination as unchanged drug. Therefore, hepatic impairment may reduce clearance, medications inhibiting these clearance pathways could lead to drug-drug interactions. This physiologically based pharmacokinetic (PBPK) study investigated the behavior of clinical situations where drug impaired. A PBPK model was developed using...
Stability after bimaxillary surgery to correct open bite malocclusion and mandibular retrognathism was evaluated on lateral cephalograms before surgery, 8 weeks post-operatively, 2 years. The 58 consecutive patients were treated a normal occlusion good facial aesthetics. Treatment included the orthodontic alignment of teeth by maxillary fixed appliances, Le Fort I osteotomy, bilateral sagittal split ramus osteotomy. Twenty-six also had genioplasty. Intra-osseous wires or bicortical screws...
Summary The symbiosis of filarial nematodes and rickettsial Wolbachia endobacteria has been exploited as a target for antibiotic therapy filariasis. Depletion after tetracycline treatment results in sterility because interruption embryogenesis inhibits larval development adult worm viability. aim this study was to investigate if intervention BALB/c mice infected with the rodent filaria Litomosoides sigmodontis rifampicin or combination doxycycline can be used shorten period. Both regimens,...
ABSTRACT Litomosoides sigmodontis is the only filaria which develops from infective larvae into microfilaria-producing adults in immunocompetent laboratory mice. In this study we report that interleukin-4 knockout (IL-4 KO) mice have an up to 100-fold-higher and a significantly prolonged microfilaremia compared wild-type BALB/c mice, as well 20 times more microfilariae thoracic cavity, site of infection. While worm development adult persistence were equivalent IL-4 KO fertility length female...