A5003186425- Multiple Myeloma Research and Treatments
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Chemokine receptors and signaling
- Protein Kinase Regulation and GTPase Signaling
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Calcium signaling and nucleotide metabolism
- CAR-T cell therapy research
- Bone health and treatments
- Angiogenesis and VEGF in Cancer
- Reproductive System and Pregnancy
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Bone Metabolism and Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Treatment and Pharmacology
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
Dana-Farber Cancer Institute
2023-2025
Duke University Hospital
2025
Regeneron (United States)
2023
Roche (Switzerland)
2023
Duke University
2021-2022
University of Washington
2017
Délégation Paris 5
2012-2015
Institut Cochin
2012-2015
Université Paris Cité
2012-2015
Centre National de la Recherche Scientifique
2012-2015
Hypertrophic chondrocytes give rise to osteoblasts during skeletal development; however, the process by which these non-mitotic cells make this transition is not well understood. Prior studies have also suggested that stem and progenitor (SSPCs) localize surrounding periosteum serve as a major source of marrow-associated SSPCs, osteoblasts, osteocytes, adipocytes development. To further understand cell hypertrophic contribute or other marrow associated cells, we utilized inducible...
Background In diabetic patients, the pharmacokinetics of injected human insulin does not permit optimal control glycemia. Fast and slow acting analogues have been developed, but they may adverse properties, such as increased mitogenic or anti-apoptotic signaling. Insulin/IGF1 hybrid receptors (IR/IGF1R), present in most tissues, proposed to transmit biological effects close those IGF1R. However, study is difficult because presence IR IGF1R homodimers. Our objective was perform first on...
Enchondromas are common bone tumors composed of chondrocytes originating from growth plate cells which can progress to malignant chondrosarcoma. Mutations in the genes encoding isocitrate dehydrogenase (IDH1 and IDH2) identified a large proportion these tumors. IDH enzymes convert alpha-ketoglutarate (α-KG), an essential component citric acid cycle. While mutant produce 2-hydroxyglutarate, has epigenetic effects important tumor initiation, cell maintenance rely on additional factors. Prior...
Abstract Chromosomal aberrations often represent early events in cancer development and might play a critical role establishing malignant clones. Large chromosomal deletions typically involve the loss of multiple cooperating tumor suppressor genes, which makes it challenging to study their contribution pathogenesis. Recent genomic studies have identified MYD88L265P mutation chromosome 6q deletion as frequent alterations Waldenstrom’s macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL)....
The inactivation of ribosomal protein S6 kinase 1 (S6K1) recapitulates aspects caloric restriction and mTORC1 inhibition to achieve prolonged longevity in invertebrate mouse models. In addition delaying normative aging, extends the shortened lifespan yeast, fly, models with severe mitochondrial disease. Here we tested whether disruption S6K1 can recapitulate beneficial effects Ndufs4 knockout (NKO) model Leigh Syndrome caused by Complex I deficiency. These NKO mice develop profound...
Insulin analogues are largely used for the treatment of diabetic patients, but concerns have been raised about their mitogenic/anti-apoptotic potential. It is therefore important to evaluate these in different cell systems.The aim this work was establish pharmacological profiles insulin towards PI-3 kinase/Akt pathway INS-1 β-pancreatic cells.Bioluminescence Resonance Energy Transfer (BRET), western and caspase 3/7 assays, study effects ligands.Among five evaluated, only glargine stimulated...
Multiple myeloma (MM) is a plasma cell malignancy that resides within the bone marrow microenvironment, relying heavily on interactions with its cellular components. Among these, endothelial cells (ECs) play pivotal role in MM progression and development of therapeutic resistance. In this study, we analyzed publicly available single-cell RNA sequencing data to identify unique pathway activations distinguishing ECs from patients healthy donors. We developed novel protocol isolate culture...
Multiple myeloma (MM) is a plasma cell malignancy that resides within the bone marrow microenvironment, relying heavily on interactions with its cellular components. Among these, endothelial cells (ECs) play pivotal role in MM progression and development of therapeutic resistance. In this study, we analyzed publicly available single-cell RNA sequencing data to identify unique pathway activations distinguishing ECs from patients healthy donors. We developed novel protocol isolate culture...
ABSTRACT Hypertrophic chondrocytes give rise to osteoblasts during skeletal development; however, the process by which these non-mitotic cells make this transition is not well understood. Prior studies have also suggested that stem and progenitor (SSPCs) localize surrounding periosteum serve as a major source of marrow associated SSPCs, osteoblasts, osteocytes, adipocytes development. To further understand cell hypertrophic contribute or other cells, we utilized inducible constitutive...