A5100654347- Gene Regulatory Network Analysis
- Nonlinear Dynamics and Pattern Formation
- Evolution and Genetic Dynamics
- Acute Ischemic Stroke Management
- S100 Proteins and Annexins
- Eicosanoids and Hypertension Pharmacology
- RNA modifications and cancer
- Pharmacological Receptor Mechanisms and Effects
- Cardiovascular Disease and Adiposity
- Cardiac Ischemia and Reperfusion
- Cancer-related molecular mechanisms research
- Heavy Metal Exposure and Toxicity
- Oral and Maxillofacial Pathology
- Hormonal Regulation and Hypertension
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Intracranial Aneurysms: Treatment and Complications
- Renal and related cancers
- Genomics, phytochemicals, and oxidative stress
- Bioinformatics and Genomic Networks
- Trace Elements in Health
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Reactions and Mechanisms
- Protease and Inhibitor Mechanisms
Liaoning Cancer Hospital & Institute
2024
Dalian University of Technology
2024
Zhongnan Hospital of Wuhan University
2022-2024
Wuhan University
2022-2024
Southern Medical University
2018-2021
Zhujiang Hospital
2018-2021
Changchun University of Chinese Medicine
2020
Beijing Luhe Hospital Affiliated to Capital Medical University
2019
Changchun Obstetrics and Gynecology Hospital
2015
Sun Yat-sen Memorial Hospital
2013
The study of the collective dynamics synchronization among genetic oscillators is essential for understanding rhythmic phenomena living organisms at both molecular and cellular levels. Genetic are biochemical networks, which can generally be modelled as nonlinear dynamic systems. We show in this paper that many transformed into Lur'e form by exploiting special structure biological By using a control theory approach, we provide theoretical method analysing coupled nonidentical oscillators....
Gene regulation is an intrinsically noisy process, which subject to intracellular and extracellular noise perturbations environment fluctuations. In this brief, we consider a stochastic nonlinear model for genetic regulatory networks with SUM functions. Based on the Lyapunov method Lur'e system approach, sufficient conditions stability of disturbance attenuation are derived. The case time delays owing slow processes transcription, translation, translocation also studied. All results...
The study of synchronization among genetic oscillators is essential for the understanding rhythmic phenomena living organisms at both molecular and cellular levels. Genetic networks are intrinsically noisy due to natural random intra- inter-cellular fluctuations. Therefore, it important effects noise perturbation on synchronous dynamics oscillators. From synthetic biology viewpoint, also implement biological systems that minimizing negative influence perturbations. In this paper, based...
Abstract CircLRIG1 , a newly discovered circRNA, has yet to have its potential function and biological processes reported. This study explored the role of circLRIG1 in development progression bladder carcinoma molecular mechanisms. Techniques such as qRT-PCR, Western blot, various cellular assays, vivo models were used investigate mRNA protein levels, cell behavior, interactions, tumor growth. The results showed that both LRIG1 significantly reduced tissues lines. Low expression was...
Detection of cancer and identification tumor origin at an early stage improve the survival prognosis patients. Herein, we proposed a plasma cfDNA-based approach called TOTEM to detect trace signal (CSO) through methylation markers.
Background RNA-binding proteins (RBPs) have important roles in orchestrating posttranscriptional regulation and modulating many tumorigenesis events. SERBP1 has been recognized as an regulator multiple cancers, while it remains unclear whether SERBP1-regulated gene expression at the transcriptome-wide level is significantly correlated with tumorigenesis. Methods We overexpressed HeLa cells explored overexpression (SERBP1-OE) affects proliferation apoptosis of cells. analyzed changes...
Patients with non-disabling middle cerebral artery (MCA) stenosis (ND-MCAS) are at risk for disabling ischemic cerebrovascular events (DICE) despite aggressive medical therapy. In this study, we aimed to verify whether circulation time (CCT) was a potential predictor of DICE in patients ND-MCAS. From January 2015 2020, 46 ND-MCAS treated therapy were enrolled digital subtraction angiography (DSA) convenience sampling study. They divided into the (–) and (+) groups based on occurrence within...
Background and Objective: Heart attack or Myocardial infarct (MI) is one of the serious health issue as it claims many lives than any other heart disease.The present experiment was framed to explore cardioprotective efficacy naringenin (NG) against isoproterenol (ISO) induced failure (cardiotoxicity) in a rat model.Materials Methods: A total 32 male albino rats were procured segregated into 4 groups control-rats treated with saline (14 days), NG alone group-rats orally 50 mg kgG 1 for 14...
The study of synchronization among genetic oscillators is essential for the understanding rhythmic phenomena living organisms at both molecular and cellular levels. Genetic networks are intrinsically noisy due to natural random intra- inter-cellular fluctuations. Therefore, it important effects noise perturbation on synchronous dynamics oscillators. From synthetic biology viewpoint, also implement biological systems that minimizing negative influence perturbations. In this paper, based...
Epidemiological studies and clinical observations have indicated that cold temperature can trigger the occurrence of stroke in individuals at high risk. However, underlying mechanisms are still unknown. Matrix metalloproteinase-9 (MMP-9) has been found to be associated with formation, progression rupture atherosclerotic plaques cerebral aneurysms, which is pathological basis stroke. Cold activates renin-angiotensin system (RAS) circulation tissue. Angiotensin Ⅱ implicated inducing MMP-9...
The synthesis and characterization of Co(II)CI2 Cu(II)Cl2 complexes with 2-chloro-10-(3-dimethylaminopropyl)phenothiazine-5-oxide hydrochloride (cpz(O)HCl) three related compounds are described. crystal structures the [CoCl3cpz(O)H] (1) [CuCl3 cpz(O)H] (2) were determined by single-crystal X-ray diffraction analyses. 1 crystallizes in monoclinic space group P21/c a=8.150(1), b=17.763(2), c=14.630(2) Å, β=103.93(1)°, V=2055.8(3) Å3, Z=4. 2 a=8.141(1), b=17.175(4), c=14.810(3) β=103.27(1)°,...
Abstract Background : Stroke-associated pneumonia (SAP) is a major complication after stroke, oral microorganisms are important contributors to SAP. Here, we aimed investigate whether the hygiene was associated with SAP and related risk factors of them in patients acute ischemic stroke. Methods: We performed cross-sectional study that recruited 331 stroke from two medical centers. A series assessments were evaluate neurological status habits hygiene. According abnormal occurred, univariate...