A5072039936- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- Mercury impact and mitigation studies
- Neonatal and fetal brain pathology
- Receptor Mechanisms and Signaling
- Toxic Organic Pollutants Impact
- Genetics and Neurodevelopmental Disorders
- Animal Behavior and Reproduction
- Memory and Neural Mechanisms
- Animal Behavior and Welfare Studies
- Primate Behavior and Ecology
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Heavy Metal Exposure and Toxicity
- Eicosanoids and Hypertension Pharmacology
- Treatment of Major Depression
- Effects of Environmental Stressors on Livestock
- Pain Management and Placebo Effect
- Reproductive System and Pregnancy
- Maternal Mental Health During Pregnancy and Postpartum
Ospedale Civile di Vittorio Veneto
2017-2024
Sapienza University of Rome
2010-2023
Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting permanent behavioral and neurobiological outcomes. Although sexual dimorphism the effects PRS has been hypothesized for more than 30 years, few studies this long period have directly addressed issue. Our group uncovered pronounced gender difference (stress delivered to mothers 3 times per day during last 10 days pregnancy) on anxiety, spatial learning, series parameters classically associated with...
Abstract Brain aging as well brain degenerative processes with accompanying cognitive impairments are generally associated hyperactivity of the hypothalamus‐pituitary‐adrenal axis, end product which, glucocorticoid hormone, has been warranted role cell damage primum movens (“cascade hypothesis”). However, chronic inflammatory activity occurs in hippocampus aged rats Alzheimer's disease patients. The concomitant increase secretion endogenous anti‐inflammatory and pro‐inflammatory markers,...
Abstract Agomelatine is a novel antidepressant acting as an MT1/MT2 melatonin receptor agonist/5-HT2C serotonin antagonist. Because of its peculiar pharmacological profile, this drug caters the potential to correct abnormalities circadian rhythms associated with mood disorders, including sleep/wake cycle. Here, we examined effect chronic agomelatine treatment on sleep architecture and motor activity using rat model prenatal restraint stress (PRS) putative ‘aetiological’ depression. PRS was...
Vortioxetine is a multimodal antidepressant that potently antagonizes 5-HT3 serotonin receptors, inhibits the high-affinity transporter, activates 5-HT1A and 5-HT1B 5-HT1D 5-HT7 receptors. receptors largely mediate hyperalgesic activity of occurs in response to nerve injury. Activation contributes explain why selective reuptake inhibitors, such as fluoxetine, are not indicated treatment neuropathic pain. Here, we studied analgesic action vortioxetine chronic constriction injury model pain...
A growing body of evidence underscores the importance early life events as predictors health in adulthood. Abnormalities maternal care or other forms postnatal stress induce long-term changes behavior and influence vulnerability to illnesses throughout life. Some these may be produced by activation hypothalamic-pituitary-adrenal (HPA) axis, which is invariably associated with stress. We used a model neonate rats are fed mothers drinking water supplemented 0.2 mg/ml corticosterone, main...
Abstract Anoxia in the first week of life can induce neuronal death vulnerable brain regions usually associated with an impairment cognitive function that be detected later life. We set‐up a model subneurotoxic anoxia based on repeated exposures to 100% nitrogen during 7 days post‐natal This mild exposure specifically modified behaviour male adult rats, which showed attention deficit and increase anxiety, without any spatial learning detectable damage (magnetic resonance imaging histological...
Knowledge of animals' hormonal status is important for conservation studies in wild or semi-free-ranging conditions as well behavioural and clinical experiments conducted laboratory research, mostly performed on rats mice. Faecal sampling a useful non-invasive method to obtain steroid hormone assessments. Nevertheless, studies, unlike other contexts, faecal less utilised. One the issues raised necessity collect samples belonging different animals, separately. Usually, researchers using solve...
Maternal-fetal HIV-1 transmission can be prevented by administration of AZT, alone or in combination with other antiretroviral drugs to pregnant HIV-1-infected women and their newborns. In spite the benefits deriving from this life-saving prophylactic therapy, there is still considerable uncertainty on potential long-term adverse effects exposed children. Clinical experimental studies have consistently shown occurrence mitochondrial dysfunction increased oxidative stress following prenatal...
mGlu5 receptor-mediated polyphosphoinositide (PI) hydrolysis is classically measured by determining the amount of radioactivity incorporated in inositolmonophosphate (InsP) after labeling membrane phospholipids with radioactive inositol. Although this method historically linked to study mGlu receptors, it inappropriate for assessment receptor signaling vivo. Using a new ELISA kit we showed that systemic treatment selective positive allosteric modulator (PAM) receptors VU0360172 enhanced InsP...
The early phase of life represents a critical period for the development an organism. Interestingly, experiences are able to influence gastrointestinal tract and reactivity colonic inflammatory stress. We recently demonstrated that adult male rats exposed low doses corticosterone during lactation (CORT-nursed rats) protected against experimental colitis induced by intracolonic infusion 2,4,6-trinitrobenzenesulfonic acid (TNBS). Based on these interesting results, we wanted better investigate...
Using an in vivo method for the assessment of polyphosphoinositide (PI) hydrolysis, we examine whether spatial learning and memory extinction cause changes mGlu5 metabotropic glutamate receptor signaling hippocampus prefrontal cortex. We use following five groups mice: (i) naive mice; (ii) control mice exposed to same environment as learner (iii) leaner mice, trained four days a water maze; (iv) which was induced by six trials without platform; (v) that spontaneously lost memory. The...