A5012283848- Neonatal Respiratory Health Research
- Antioxidant Activity and Oxidative Stress
- Respiratory Support and Mechanisms
- Pregnancy and preeclampsia studies
- Fatty Acid Research and Health
- Birth, Development, and Health
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Retinoids in leukemia and cellular processes
- Folate and B Vitamins Research
- Renal function and acid-base balance
- Tendon Structure and Treatment
- Empathy and Medical Education
- COVID-19 and Mental Health
- Healthcare professionals’ stress and burnout
- Eicosanoids and Hypertension Pharmacology
- Gestational Diabetes Research and Management
- Bee Products Chemical Analysis
- Nutritional Studies and Diet
- Traumatic Brain Injury and Neurovascular Disturbances
- Cellular Mechanics and Interactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Electrolyte and hormonal disorders
- Anesthesia and Neurotoxicity Research
University of Colorado Anschutz Medical Campus
2024
University of Colorado Denver
2021-2024
Lung Institute
2023-2024
University of Rochester Medical Center
2022
University of Rochester
2022
University of Colorado System
2022
Children's Hospital Colorado
2021
University of Nebraska Medical Center
2017-2020
"Dysanapsis as a Determinant of Lung Function in Development and Disease." American Journal Respiratory Critical Care Medicine, 208(9), pp. 956–963
Omega (n)-3 fatty acids are vital to neonatal maturation, and recent investigations reveal n-3 serve as substrates for the biosynthesis of specialized pro-resolving lipid mediators (SPM) that have anti-inflammatory immune-stimulating effects. The role SPM play in protection against negative maternal-fetal health outcomes is unclear, there no current biomarkers acid sufficiency. We sought ascertain relationships between intake, levels, outcomes. obtained intake information from 136 mothers...
Tendons are composed of a heterogeneous cell environment, with Scleraxis -lineage ( Scx Lin ) cells being the predominant population. Although required for maintenance tendon homeostasis, their functions during healing unknown. To this end, we first characterized spatiotemporal dynamics healing, and identified that overall pool continuously expands up to early remodeling phase. better define function late proliferative phase inducibly depleted from day 14–18 post-surgery using Scx-Cre;...
<b><i>Background:</i></b> Vitamin A is an essential nutrient for pregnant women, and other vitamin A-related compounds, including lutein lycopene, have been associated with maternal-infant outcomes. The objective of this study was to quantify the status related compounds in pairs at time delivery, determine its impact on clinical <b><i>Methods:</i></b> Maternal cord blood samples were collected 189 mother-infant pairs. Concentrations +...
Oxidative stress is associated with adverse pregnancy outcomes, and vitamin E has powerful anti-oxidant properties the potential to impact health outcomes. Tocopherol isomers of differ in their ability modulate inflammation vary concentration diets containing high proportions processed versus unprocessed foods. The purpose this study was compare status outcomes (mode delivery, chorioamnionitis, APGARs (measure appearance, pulse, grimace, activity, respiration), gestational age at fetal...
Abstract The objective of the present study was to evaluate intakes and serum levels vitamin A, E, related compounds in a cohort maternal–infant pairs Midwestern USA relation measures health disparities. Concentrations carotenoids tocopherols maternal were measured using HPLC socio-economic status, including food security desert residence, obtained 180 mothers upon admission Academic Medical Center labour delivery unit. Kruskal–Wallis independent-samples t tests used compare between groups;...
Abstract Objective The primary aim of this study was to evaluate the association between 25-hydroxyvitamin D (25OHD) concentration at birth and short-term outcomes in neonatal hypoxic–ischemic encephalopathy (HIE). Our secondary effect postnatal vitamin supplementation on perinatal period after hypoxic injury. Study Design This retrospective cohort included all infants ≥35 weeks gestation admitted a regional level IV intensive care unit diagnosed with moderate or severe HIE. Spearman...
Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, is characterized by impaired development with sustained functional abnormalities due to alterations airways and distal lung. Although clinical studies have shown striking associations between antenatal stress BPD, little known about underlying pathogenetic mechanisms. Whether dysanapsis, concept discordant growth parenchyma, contributes late respiratory as a result unknown. We hypothesized that endotoxin (ETX) impairs...
The COVID-19 pandemic introduced a myriad of changes that negatively impacted resident physicians' well-being. Communication from program leadership may mitigate stress during times crisis, yet literature supporting this premise is scant, and best communication practices remain uncertain. This qualitative study aimed to identify stressors residents explore the influence residency leadership's on emotional pandemic.
Introduction: Bronchopulmonary dysplasia (BPD), chronic lung disease of prematurity, is characterized by impaired development, but mechanisms that lead to sustained functional abnormalities into child- and adulthood are uncertain. We have previously shown intra-amniotic endotoxin (IA ETX) exposure, mimic chorioamnionitis, causes abnormal distal structure. Whether dysanapsis, disproportionate growth airways parenchyma, contributes function respiratory in BPD unknown. Methods: Fetal rats were...