A5068163767- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Eating Disorders and Behaviors
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Bariatric Surgery and Outcomes
- RNA Research and Splicing
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- Traffic control and management
- Sleep and related disorders
- RNA modifications and cancer
- Traffic Prediction and Management Techniques
- Alcohol Consumption and Health Effects
- Digital Mental Health Interventions
- Diet, Metabolism, and Disease
- Impact of Technology on Adolescents
- Prenatal Substance Exposure Effects
- Mobile Health and mHealth Applications
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Transportation Planning and Optimization
Novo Nordisk (United States)
2023-2025
University of Iowa
2024-2025
University of California, Berkeley
1999-2025
Washington State University
2016-2024
University of Cincinnati
2005-2016
University of Cincinnati Medical Center
2012
The University of Texas Southwestern Medical Center
2007
National Renewable Energy Laboratory
1999
Recent studies indicate that decreased central dopamine is associated with diet-induced obesity in humans and animal models. In the current study, authors assessed hypothesis reduces mesolimbic function. Specifically, compared turnover this region between rats fed a high-fat diet those consuming standard low-fat diet. The also behavioral consequences of by testing response these animals conditioned place paradigm using amphetamine as reinforcer an operant conditioning sucrose reinforcement....
Individuals often eat calorically dense, highly palatable “comfort” foods during stress for relief. This article demonstrates that food intake (limited of sucrose drink) reduces neuroendocrine, cardiovascular, and behavioral responses to in rats. Artificially sweetened (saccharin) drink reproduces the dampening, whereas oral intragastric gavage is without effect. Together, these results suggest palatable/rewarding properties are necessary sufficient dampening. In support this finding,...
High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable can promote overeating, the neurobiological mechanisms that underlie selective appetite for sugar in states satiety remain unclear. Hypothalamic pro-opiomelanocortin (POMC) neurons principal regulators because they decrease food intake through excitatory melanocortin neuropeptides. We discovered POMC not only fed conditions but...
Hypothalamic orexin neurons project to numerous brain areas, including the ventral tegmental area (VTA), which is involved in motivation and food-seeking behavior. Here we address how exogenously administered orexin-A endogenous 1 receptor (OX1R) activation VTA affects feeding We hypothesized that OX1R antagonist SB334867 delivered VTA, at doses were subthreshold for effect when injected into ventricle, would affect intake of palatable foods multiple test situations. first used a hedonic...
Objective To evaluate differences in mental health and substance use circumstances by rurality military affiliations among suicide decedents. Methods Multiyear (2009–2019) cross-sectional study of adult decedents reported to the National Violent Death Reporting System. We classified into a four-level variable geography (urban/rural) status evaluated prevalence current past alcohol problems, problem recognition illness treatment. estimated ratios using multiple imputation chain equations...
Circulating angiotensin II (ANGII) elicits water intake and activates the hypothalamic-pituitary-adrenal (HPA) axis by stimulating type 1 receptors (AT1Rs) within circumventricular organs. The subfornical organ (SFO) organum vasculosum of lamina terminalis (OVLT) are organs that express AT1Rs bind blood-borne ANGII stimulate integrative effector regions brain. goal these studies was to determine contribution SFO OVLT HPA response increased circulating ANGII. Antisense oligonucleotides...