A5103149923- MRI in cancer diagnosis
- Renal cell carcinoma treatment
- Advanced MRI Techniques and Applications
- Renal and related cancers
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- RNA modifications and cancer
- Lanthanide and Transition Metal Complexes
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Advanced NMR Techniques and Applications
- Pregnancy and preeclampsia studies
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Myeloid Leukemia Research
- Atomic and Subatomic Physics Research
- Nuclear Structure and Function
- Cytokine Signaling Pathways and Interactions
Medanta The Medicity
2024
The University of Texas Southwestern Medical Center
2014-2024
Southwestern Medical Center
2013-2024
Advanced Imaging Research (United States)
2017-2024
Mayo Clinic
2024
Bayer (United States)
2024
Medanta The Medicity
2022
All India Institute of Medical Sciences
2019
Houston Methodist
2015-2017
Radiation Oncology Institute
2017
Cell-cycle phase is a critical determinant of the choice between DNA damage repair by nonhomologous end-joining (NHEJ) or homologous recombination (HR). Here, we report that double-strand breaks (DSBs) induce ATM-dependent MOF (a histone H4 acetyl-transferase) phosphorylation (p-T392-MOF) and phosphorylated colocalizes with γ-H2AX, ATM, 53BP1 foci. Mutation site (MOF-T392A) impedes in S G2 but not G1 cells. Expression MOF-T392A also blocks reduction DSB-associated seen wild-type S/G2 cells,...
The biological effects of ionizing radiation are attributable, in large part, to induction DNA double-strand breaks. We report here the identification a new protein factor that reconstitutes efficient break rejoining when it is added reaction containing five other polypeptides known participate human nonhomologous end-joining pathway. stable heteromeric complex polypyrimidine tract-binding protein-associated splicing (PSF) and 54-kDa nuclear RNA-binding (p54(nrb)). These polypeptides, which...
Checkpoint kinase inhibitors (CHKi) exhibit striking single-agent activity in certain tumors, but the mechanisms accounting for hypersensitivity are poorly understood. We screened a panel of 49 established human head and neck squamous cell carcinoma (HNSCC) lines report that nearly 20% hypersensitive to CHKi monotherapy. Hypersensitive cells underwent early S-phase arrest at drug doses sufficient inhibit greater than 90% CHK1 activity. Reduced rate DNA replication fork progression...
Dysregulated lipid and glucose metabolism in clear cell renal carcinoma (ccRCC) has been implicated disease progression, whole tumor tissue-based assessment of these changes is challenged by the heterogeneity. We studied a noninvasive quantitative MRI method that predicts metabolic alterations tumor.We applied Dixon-based for vivo quantification accumulation (fat fraction [FF]) targeted regions interest 45 primary ccRCCs correlated measures to mass spectrometry-based lipidomics metabolomics...
Abstract Purpose: Intratumoral heterogeneity (ITH) challenges the molecular characterization of clear cell renal carcinoma (ccRCC) and is a confounding factor for therapy selection. Most approaches to evaluate ITH are limited by two-dimensional ex vivo tissue analyses. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can noninvasively assess spatial landscape entire tumors in their natural milieu. To potential DCE-MRI, we developed vertically integrated radiogenomics...
Proliferating mammalian stem and cancer cells express telomerase [telomerase reverse transcriptase (TERT)] in an effort to extend chromosomal G-overhangs maintain telomere ends. Telomerase-expressing also have higher levels of the single-stranded DNA-binding protein SSB1, which has a critical role DNA double-strand break (DSB) repair. Here, we report that SSB1 binds specifically G-strand telomeric vitro associates with telomeres vivo. interacts TERT catalytic subunit regulates its...
Widespread use of screening mammography has recently increased the detection breast microcalcifications. These nonpalpable microcalcifications with specific features in tissues are clinically considered an early indicator carcinoma. Our goal this study was to develop a murine microcalcification model for optimizing vivo imaging. Recombinant human BMP-2 expressed E. coli, and purified bioactive protein used as inducing factor production animal model. Syngeneic tumors were obtained by...
Background: Placental development occurs concurrently with fetal cardiogenesis and share many developmental pathways. Recent data from animal models suggest a link between placental inflammation abnormal heart development, but no studies have elucidated the molecular processes connecting specific lesions to congenital disease (CHD) in humans. Objective: To determine differentially expressed genes affected biological tissue pregnancies complicated by left ventricular outflow tract obstruction...
Chondrosarcoma (CS) is one of the common malignant bone tumours arising from chondrocytes with variable degrees malignancy. It mainly noted in flat bones like pelvis and scapula, sometimes long proximal femur. This case report describes a 40-year-old female who presented pain over her right great toe for six months swelling four months. An open biopsy revealed low-grade CS. Subsequently, patient underwent amputation first ray till tarsometatarsal joint meticulous dissection tumour mass. At...
We evaluated the intra-session repeatability and inter-session reproducibility of brain tumor perfusion measured using 3D pseudo-continuous Arterial spin labeled (PCASL) MRI with TSE based Cartesian acquisition spiral profile reordering (CASPR) in comparison to pCASL GRASE healthy volunteers glioblastoma (GBM) patients at 3T. TSE-CASPR or provided high 3 weeks both GBM patients. While readouts generated robust images, images reduced distortion particularly could be a better readout for
WBMRI-DETECT has been previously shown to have improved lesion conspicuity and shorter scan times compared WBMRI-STIR WBMRI-DWIBS in multiple myeloma. In this work, we demonstrate that quantitative biomarkers measured through WBMRI, fat fraction (FF) apparent diffusion coefficient (ADC), weak correlation suggesting both provide complementary information. Additionally, ADC FF showed negative with the semiquantitative SUVmax from FDG-PET, demonstrating potential use of MRI for assessment...
We evaluated whether arterial spin labeled (ASL) MRI is competitive or complementary to dynamic susceptibility contrast (DSC) measured perfusion in 20 glioblastoma (GBM) patients among 78 imaging sessions. In over 90% of scans, ASL was DSC. Among these cases, either equivalent superior DSC, making a very attractive alternative some cases (less than 10%), however, and DSC were each other combining their strength could provide more comprehensive information the whole tumor.