A5003035311- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Cardiac pacing and defibrillation studies
- Cancer, Lipids, and Metabolism
- Cardiac Arrhythmias and Treatments
- Vehicle emissions and performance
- Cardiac electrophysiology and arrhythmias
- RNA and protein synthesis mechanisms
- Electrolyte and hormonal disorders
- Phytoestrogen effects and research
- Telomeres, Telomerase, and Senescence
- Advanced biosensing and bioanalysis techniques
- Advanced Fluorescence Microscopy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Autonomous Vehicle Technology and Safety
- Intensive Care Unit Cognitive Disorders
- Traffic Prediction and Management Techniques
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
Huashan Hospital
2015-2025
Fudan University
2015-2025
State Key Laboratory of Genetic Engineering
2023-2025
Anhui Medical University
2024
Hunan University of Science and Technology
2024
Abstract Objectives to Background To compare electromechanical ventricular synchrony when pacing from different sites, including right apex (RVAP), septum (RVSP), His bundle (HBP), left branch (LBBP), and RVSP during unipolar the ring electrode of LBBP lead (RVSP ) in each patient evaluate correlations between electrophysiological characteristics synchrony. Methods Twenty patients with complete atrioventricular block indicated for dual‐chamber pacemaker implantation were included study....
Cryptic transcription initiation has been previously linked to activation of oncogenic transcripts. However, the prevalence and impact cryptic antisense from opposite strand protein-coding genes were mostly unknown in cancer. Applying a robust computational pipeline publicly available transcriptome epigenome datasets, we identified hundreds unannotated polyadenylated transcripts (CAPTs) that enriched tumor samples. We showed was associated with increased chromatin accessibility active...
Objectives: To compare electromechanical ventricular synchrony when pacing from different sites including right apex (RVAP), septum (RVSP), His Bundle (HBP), left bundle branch (LBBP) and RVSP during unipolar the ring electrode of LBBP lead (RVSPring ) in each patient. Methods: Twenty patients with complete atrioventricular block (AVB) indicated for dual-chamber pacemaker implantation were included. Unipolar at RVAP, RVSP，HBP，LBBP RVSPring successively performed. Pacing characteristics...
<title>Abstract</title> Metabolic plasticity and ferroptosis are essential for colorectal cancer (CRC) progression. The effects prognostic value of metabolic plasticity- ferroptosis-related genes (MPFRGs) in CRC remain unclear. We established a model patients by identifying important ferroptosis. Data were retrieved from Cancer Genome Atlas (TCGA) Gene Expression Omnibus; MPFRG data obtained GeneCards FerrDb. performed functional (to explore differences between the two subtypes)...
Abnormal transcription initiation from alternative first exon has been reported to promote tumorigenesis. However, the prevalence and impact of gene expression regulation mediated by tandem were mostly unknown in cancer. Here, we developed a robust computational method analyze start site (TSS) usage standard RNA sequencing data. Applying this pan-cancer datasets, observed widespread dysregulation TSS tumors, many which independent changes overall level or usage. We showed that dynamics was...
Metabolic plasticity and ferroptosis are essential for colorectal cancer (CRC) progression. The effects prognostic value of metabolic plasticity- ferroptosis-related genes (MPFRGs) in CRC remain unclear. We established a model patients by identifying important ferroptosis. Data were retrieved from Cancer Genome Atlas (TCGA) Gene Expression Omnibus; MPFRG data obtained GeneCards FerrDb. performed functional (to explore differences between the two subtypes) single-sample gene set assess immune...
Drug resistance to a single agent is common in cancer-targeted therapies, and rational drug combinations are promising approach overcome this challenge. Many Food Administration-approved drugs can induce cellular senescence, which possesses unique vulnerabilities molecular signatures. However, there limited analysis on the effect of combination cellular-senescence-inducing targeted therapy drugs. Here, we conducted comprehensive evaluation senescence using 7 senescence-associated gene sets....