A5044696111- Immune Cell Function and Interaction
- Glaucoma and retinal disorders
- Metal complexes synthesis and properties
- IL-33, ST2, and ILC Pathways
- Ferrocene Chemistry and Applications
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Galectins and Cancer Biology
- Click Chemistry and Applications
- Retinal Diseases and Treatments
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Cerebral Venous Sinus Thrombosis
- Toxin Mechanisms and Immunotoxins
- NF-κB Signaling Pathways
- Adenosine and Purinergic Signaling
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Genomics, phytochemicals, and oxidative stress
- Ocular Surface and Contact Lens
- Chemokine receptors and signaling
- Corneal surgery and disorders
University of Kragujevac
2014-2024
Institut Bisnis Nusantara
2003
The promotion of tumor growth is due to a combination several mechanisms, including angiogenesis and the abundance cell-derived inflammatory cytokines. aim this study was investigate serum levels interleukin 17 (IL-17) expression p53 Vascular Endothelial Growth Factor (VEGF), in order determine relationship between these markers IL-17 patients with colorectal carcinoma. Serum proinflammatory cytokine carcinoma (CRC) (n=40) healthy group (n=37) were analysed by ELISA. Surgically resected...
A series of mono- and heteronuclear platinum(II) zinc(II) complexes with 4,4′,4″-tri-tert-butyl-2,2′:6′,2″-terpyridine ligand were synthesized characterized. The DNA protein binding properties [ZnCl2(terpytBu)] (C1), [{cis-PtCl(NH3)2(μ-pyrazine)ZnCl(terpytBu)}](ClO4)2 (C2), [{trans-PtCl(NH3)2(μ-pyrazine)ZnCl(terpytBu)}](ClO4)2 (C3), [{cis-PtCl(NH3)2(μ-4,4′-bipyridyl)ZnCl(terpytBu)}](CIO4)2 (C4) [{trans-PtCl(NH3)2(μ-4,4′-bipyridyl)ZnCl(terpytBu)}](CIO4)2 (C5) (where terpytBu =...
Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of pancreatic β-cells. Prevention type requires early intervention in process against beta-cells islets Langerhans, which believed to result from disordered immunoregulation. CD4+Foxp3+ regulatory T cells (Tregs) participate as one most important cell types limiting process. The aim this study was investigate effect exogenous IL-33 multiple low dose streptozotocin (MLD-STZ) induced and delineate its role...
Aims/hypothesis: Galectin 3 appears to have proinflammatory role in several inflammatory and autoimmune diseases. Also, there is evidence that galectin plays a both, type 1 2 diabetes. During obesity hematopoetic cells-derived induces insulin resistence. While the of expressed islet invading immune cells both diabetes has been studied, importance expression this molecule on target pancreatic beta not defined. Methods: To clarify during obesity-induced diabetogenesis, we developed transgenic...
The newly developed mononuclear 5,6-epoxy-5,6-dihydro-1,10phenanthroline platinum(II) complex revealed notable antitumor effects in vitro and vivo. In this study, the of on immune response were assessed. Peritoneal macrophages splenocytes obtained from mice treated with lipopolysaccharide (LPS)/Concanavalin A (ConA) along measurement cytokine concentrations immunophenotyping was performed. Our findings indicate that exhibits significant immunomodulatory peritoneal splenocytes.
To reveal the roles of proinflammatory cytokines within process pseudoexfoliation (PEX) production.Our study included 120 patients referred to cataract surgery (early and late stage syndrome (XFS), glaucoma (XFG), control group). Serum humor levels were measured in a sample with high sensitivity enzyme-linked immunosorbent assay (ELISA) kit.Our findings revealed that TNF-α IL-17, overlooked by IL-6 action early phase glaucoma, played main role inflammation activation tissue XFS XFG.Local...
To establish the role of nitric oxide (NO), ascorbic acid and tumour necrosis factor-α (TNF-α) in pathogenesis pseudoexfoliation glaucoma (XFG).Our study included 120 patients who were referred for cataract surgery. All divided into four groups according to clinical findings: XFG, early late syndrome (XFS), (without pseudoexfoliation). Serum aqueous humour levels acid, NO TNF-α measured. The concentrations measured by an appropriate spectrophotometric method. Enzyme-linked immunosorbent...
Due to the rich ethnobotanical and growing evidence-based medicine records,
Psoriasis vulgaris (PV) is a chronic skin disease with unclear pathogenesis. In the present study we investigated effect of systemic photochemotherapy (PUVA therapy- psoralen and UVA therapy) on expression IFN-γ, IL-12p40 IL-23p19 in lesional psoriatic skin. Fifteen patients plaque type psoriasis selected to be treated PUVA therapy were recruited for this study. Expression lesions before after twenty treatments was established by using immunohistochemistry (IHC). A significant decrease (p <...
The purpose of this study is to reveal the participation different regulatory cytokines within process pseudoexfoliation (PEX).Our included 140 patients referred cataract surgery with early and late stage syndrome (XFS) or glaucoma (XFG). Humor serum levels cytokines: transforming growth factor beta (TGF-β), platelet-derived (PDGF), epidermal (EGF), insulin-like (IGF), IL-8 interferon-inducible T cell alpha chemoattractant (ITAC) were measured in a sample using high sensitivity enzyme-linked...
ABSTRACT Objective: Th e aim of our study was to establish a correlation between pseudoexfoliation and its systemic manifestation. Findings: Pseudoexfoliation syndrome is an agerelated disorder that leads the overproduction accumulation pseudoexfoliated materials in visceral organs eye. Many vascular diseases are closely related with manifestations. Our results indicated there were no statistically significant diff erences (p>0.05) among patients regarding presence hypertension all...
Galectin-3 (Gal-3) has diverse roles in inflammatory and autoimmune diseases. There is evidence that Gal-3 plays a role both type 1 2 diabetes. While the of expression immune cells invading pancreatic islets experimental model diabetes mellitus been already studied, importance overexpression target β not defined. Therefore, we used multiple low doses streptozotocin (MLD-STZ)-induced C57Bl/6 mice to analyze effect transgenic (TG) cells. Our results demonstrated protected from apoptosis...
Introduction: Quercus robur L. shows anti-inflammatory, antimicrobial, antioxidative and astringent activity, contains the following chemical compounds: flavonoids, tannins, phytoncide, phlobaphenes phloroglucinol. Objective: The primary objective of this study was to investigate cytotoxic antimicrobial activity extract. Method: This designed as an experimental in vitro on microorganisms. Chopped plant material extracted using solvent (aqua) at room temperature then left dry vacuum...
Abstract Pseudoexfoliation syndrome is an age related disorder, characterized by abnormal fibrous fiber production and accumulation in different visceral organs as well the eye periocular tissues. Hystological examination recorded presence of pseudoexfoliation conjunctiva, they can disturb accessory lacrimal gland goblet cell function. This explain tear film instability patients with pseudoexfoliations. In our study, we examined stability without pseudoexfoliation, using Schirmer test break...
A novel immunomodulatory cytokine IL-41 is associated with the pathogenesis of Graves disease, Kawasaki gout, psoriatic arthritis, and rheumatoid arthritis (RA). We aimed to evaluate serum level as a biomarker RA disease activity treatment efficacy patient responses. also wanted determine eventual potential predictors concentrations.
Antitumor effect of new Pd( ii ) complexes having pyridine derivatives 2.6-dicarboxamide as chelating ligand was assessed by examination nucleophilic substitution reactions, DNA/HSA interaction, molecular docking and cytotoxic activity.
The aim of the study is detection recurrences and metastases colorectal carcinomas using 111-In labelled antibodies B72.3 in 14 patients. With tomography, we can access better distinction tumour comparison to other structures estimation its size. Other imaging methods (CT,US) have advantage liver metastases, while immunoscintigraphy more specific for assessment malignant abdominal tumours extrahepatic metastases. first results point out that Oncoscint CR-103 be useful diagnosis carcinoma,...