A5101866284- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Cytokine Signaling Pathways and Interactions
- Complement system in diseases
- Psoriasis: Treatment and Pathogenesis
- Galectins and Cancer Biology
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Retinal and Macular Surgery
- Cardiovascular Function and Risk Factors
- Renal Diseases and Glomerulopathies
- Chemokine receptors and signaling
- Neurological diseases and metabolism
- Drug-Induced Hepatotoxicity and Protection
- Platelet Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Multiple Myeloma Research and Treatments
- Liver Diseases and Immunity
- CAR-T cell therapy research
- Liver Disease and Transplantation
- Adenosine and Purinergic Signaling
- Dermatology and Skin Diseases
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
MaineGeneral Medical Center
2024
Harvard University
2024
Massachusetts General Hospital
2024
Research Network (United States)
2024
Peking University First Hospital
2021
Peking University
2021
Sinovac Biotech
2019
Thomas Jefferson University
2011-2018
Qilu Hospital of Shandong University
2018
Mast cells (MCs) have been thought to play a pathogenic role in the development of autoimmune diseases, including experimental encephalomyelitis (EAE), an animal model multiple sclerosis. However, immunoregulatory function these has recently suggested. We investigated MCs EAE using W(-sh) mouse strain, which is MC deficient. mice developed earlier and more severe clinical pathological disease with extensive demyelination inflammation CNS. The inflammatory were mainly composed CD4(+) T cells,...
Lipopolysaccharide (LPS) produced by Gram-negative bacteria induces tolerance and suppresses inflammatory responses in vivo; however, the mechanisms are poorly understood. In this study we show that LPS apoptosis of bone marrow-derived dendritic cells (DCs) modulates phenotypes DCs. treatment up-regulates expression tolerance-associated molecules such as CD205 galectin-1, but down-regulates Gr-1 B220 on CD11c(+) Moreover, regulates numbers CD8(+) , CD11b(low) CD11b(hi) DCs, which perform...
Interleukin‐10 ( IL ‐10) is an anti‐inflammatory cytokine that plays important role in regulating the local inflammatory immune response, but regulatory mechanisms of this have not been fully elucidated. Here, we demonstrate ‐10 deficiency renders LPS treatment ineffective expression CD 40, 80, 86, B 7‐ H 2, and DC on dendritic cells s) blocks upregulation ‐27. This inability to respond was found both −/− bone marrow derived splenic s. Compared with wild‐type s, −/– s expressed similar...
Infection of epithelium with human papillomavirus (HPV) 16 is generally prolonged, suggesting an ineffective virus-specific immune response, and prolonged infection promotes anogenital cancer. To determine whether poor antigen presentation by HPV-infected keratinocytes (KCs) contributes to HPV infection, KCs expressing E7 protein (E7-KCs) were compared for susceptibility T-cell-mediated lysis directed ovalbumin (OVA) processed the KCs. Interferon (IFN)-γ efficiently enhanced presenting OVA,...
Advanced non-small cell lung cancer (NSCLC) leads to a high death rate in patients and is major threat human health. NSCLC induces an immune suppressive microenvironment escapes from surveillance vivo. At present, the molecular mechanisms of immunopathogenesis induced by have not been fully elucidated. Here, we focus on effect cells development differentiation CD1c+ conventional dendritic (DC) subsets mediated CD205 CD103. The peripheral blood mononuclear (PBMCs) were isolated healthy...
Interleukin-27 (IL-27) plays an important role in regulation of anti-inflammatory responses and autoimmunity; however, the molecular mechanisms IL-27 modulation immune tolerance autoimmunity have not been fully elucidated. Dendritic cells (DCs) play a central regulating mediated by innate adaptive systems, but regulatory DCs CD4+ T cell-mediated yet Here we show that treated mature induced LPS inhibit LPS-stimulated DCs. treatment facilitates development CD127+3G11+ cell subset vitro vivo....
Purpose . Recent research has provided novel insight into the function of fibromodulin (FMOD) in wound healing and angiogenesis. The role FMOD initiation proliferative vitreoretinopathy (PVR) not been studied. This study investigated effect on human retinal pigment epithelial (RPE) cell, which plays an essential progression PVR, possible mechanisms. Methods Small interfering (si) RNA-based gene transfer technology was used to decrease expression its effects RPEs vitro Cell Counting Kit-8...
Approximately 40% of patients who survive acute episodes thrombotic thrombocytopenic purpura (TTP) associated with severe acquired ADAMTS13 deficiency experience one or more relapses. Risk factors for relapse other than and autoantibodies are unknown. autoantibodies, TTP following infection type I interferon treatment reported ensuing systemic lupus erythematosus in some suggest immune dysregulation. This cross-sectional study asked whether against RNA-binding proteins peripheral blood gene...
The generation of a robust CD8(+) cytotoxic T lymphocyte (CTL) response is key feature many immunotherapeutic strategies against epithelial tumors and virally infected tissue. However, surprisingly few studies have addressed whether primary cells, expressing defined endogenous antigens, are good targets for CTL-mediated lysis. Here, we show that keratinocytes (KCs), ovalbumin (OVA) as transgene, present measurable H-2K(b)/SIINFEKL complexes at the cell surface killed by OVA-specific CTL....
Abstract The Leucine-rich repeat kinase-2 ( LRRK2 ) G2019S mutation, resulting in aberrantly enhanced kinase activity, is one of the well-recognized genetic risk factors Parkinson’s Disease (PD). Increased activity was also observed immune cells from PD patients. Emerging results have unveiled an upsurge α-synuclein (α-syn)-specific CD4 + T cell responses Given that mutations are germline mutations, there unmet meets to explore whether mutation contributes pathogenesis via altering T-cell...
Heart failure (HF) is a clinical syndrome with high risk. Our previous research showed regulatory relationship between Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor α (PPARA) and nuclear co-repressor (NCOR1). This study aimed to investigate the mechanism of SIRT1/PPARA/NCOR1 axis in HF.
Abstract CD4+ memory T cells play an important role in induction of autoimmunity and chronic inflammatory responses. However, regulatory mechanisms cell-mediated responses are poorly understood. Here we showed that apoptotic cell-treated dendritic inhibit development differentiation effector central vitro vivo. Simultaneously, i.v. transfer cell-induced tolerogenic can block experimental autoimmune encephalomyelitis (EAE), disease nervous system C57BL/6J mouse. our results imply it is cells,...
Thrombotic thrombocytopenic purpura (TTP) is a rare life-threaten vascular autoimmune disease. There no effective method to treat it in clinical trials since pathogenesis of TTP has not been fully elucidated. Here we investigate the role NK cells relapse development TTP. Our results showed that frequencies CD3 − CD56 dim CD16 and bri are increased patients with history relapse. Expression CD107a, granzyme A IFN-γ by following vitro stimulation PMA/ionomycin / monensin improved group,...
Intracranial hypertension is one of the most common critical diseases in children that associated with worse outcome including severe brain injury, cerebral hernia and leading cause mortality morbidity children.The management strategies are aimed at treating underlying diseases, controlling elevated intracranial pressure, maintaining adequate perfusion pressure preventing hernia.Medical decreasing widely used clinical practice should be caution. Key words: Intracranial...
Abstract IL-9, which was originally identified in mice as a T cell growth factor, has attracted renewed interest because of the identification its expression by multiple helper subsets, including Th2, Th9, Th17 and regulatory cells. It been reported that IL-9 functions through activating receptor to promote cross-phosphorylation JAK1 JAK3, leading activation STAT1, STAT3 STAT5 upregulating transcription IL-9-inducible genes. remains unknown whether addition being key mediator...
Abstract Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays important role in regulating the local inflammatory immune response, but regulatory mechanisms of this have not been fully elucidated. Here we demonstrate IL-10 deficiency renders LPS treatment ineffective expression CD40, CD80, CD86, B7-H2 and B7-DC on dendritic cells (DCs) blocks up-regulation IL-27. This inability to respond was found both IL-10-/- bone marrow-derived splenic DCs. Compared wild type DCs, DCs...