A5051943021- Per- and polyfluoroalkyl substances research
- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Menopause: Health Impacts and Treatments
- Birth, Development, and Health
- Toxic Organic Pollutants Impact
- Attention Deficit Hyperactivity Disorder
- Trace Elements in Health
- Health and Wellbeing Research
- Child Nutrition and Water Access
- Smoking Behavior and Cessation
- Energy and Environment Impacts
- Pregnancy and preeclampsia studies
- Cancer Immunotherapy and Biomarkers
- Adolescent and Pediatric Healthcare
- Atmospheric Ozone and Climate
- Child Nutrition and Feeding Issues
- Child and Adolescent Health
- Climate Change and Health Impacts
- Childhood Cancer Survivors' Quality of Life
- Sleep and related disorders
- Phytoestrogen effects and research
- Maternal Mental Health During Pregnancy and Postpartum
Harvard University
2020-2024
Dartmouth College
2022-2024
Korea National Institute of Health
2014-2018
Physical activity may be an effective way of preventing or attenuating menopause-related symptoms, and it has been shown to improve quality life in menopausal women. However, there have some inconsistencies regarding between exercise study investigating this association scarce Korea. In study, the physical symptoms perimenopausal women Korea was assessed. This cross-sectional observational conducted November 2012 March 2013. total, 2,204 healthy aged 44–56 years were recruited from a...
Objective: The present study investigated the prevalence and severity of menopause symptoms experienced by Korean women aged 44 to 56 years their associated factors. Methods: A cross-sectional was performed on 2,201 in health checkup centers between November 2012 March 2013. 29-item Menopause-Specific Quality Life Questionnaire used assess vasomotor, psychosocial, physical, sexual related menopause. guidelines for classification reproductive aging stages proposed at Stages Reproductive Aging...
Background Sleep disturbance is one of the common complaints in menopause. This study investigated relationship between menopausal symptoms and sleep quality middle-aged women. Method cross-sectional observational involved 634 women aged 44–56 years attending a healthcare center at Kangbuk Samsung Hospitals. was measured using Pittsburgh Quality Index (PSQI).Multiple linear regression analysis performed to assess associations Menopause-specific Life (MENQOL) scores PSQI (MENQOL)scores....
Abstract Background: Head and neck squamous cell carcinomas (HNSCC) can occur in the oral cavity, pharynx, larynx, paranasal sinuses, nasal cavity. Immune checkpoint inhibitors (ICI) have improved survival multiple cancer types, including recurrent/metastatic (R/M) HNSCC. However, majority of patients with R/M HNSCC did not achieve objective response ICI clinical trials. Although tumor tissue DNA methylation has been proposed as a potential biomarker for response, less is known about blood...
Background: Preterm birth contributes to the morbidity and mortality of newborns infants. Recent studies have shown that maternal exposure particulate matter extreme temperatures results in immune dysfunction, which can induce preterm birth. This study aimed evaluate association between fine (PM2.5) exposure, temperature, Seoul, Republic Korea. Methods: We used 2010–2016 data from obtained Korea National Statistical Office Microdata. PM2.5 concentration Seoul were generated through Community...
It has been hypothesized that depression and obesity are bi-directionally associated, when overweight people appear to show a lower risk of depression, this supports the "Jolly Fat" hypothesis. The aim study was examine hypothesis in middle-aged women Korea, by different perceived stress levels.We performed cross-sectional 44 56 aged Korean (n = 2201) who underwent health check-up program at healthcare centers Kangbuk Samsung Hospital (Seoul Suwon centers) Korea. General abdominal were...
Background: Animal experiments indicate that environmental factors, such as cigarette smoke, can have multigenerational effects through the germline. However, there are little data on of smoking in humans. We examined associations between grandmothers’ while pregnant and risk attention-deficit/hyperactivity disorder (ADHD) her grandchildren. Methods: Our study population included 53,653 Nurses’ Health Study II (NHS-II) participants (generation 1 [G1]), their mothers 0 [G0]), 120,467...
Diethylstilbestrol (DES) is an endocrine-disrupting pharmaceutical prescribed to pregnant women prevent pregnancy complications between the 1940s and 1970s. Although DES has been shown in animal studies have multigenerational effects, only two investigated potential effects humans on preterm birth (PTB), none low birthweight (LBW)-major determinants of later life health.Nurses' Health Study (NHS) II participants (G1; born 1946-64) reported their mothers' (G0) use while with them. We used...
<h3>Importance</h3> Neurodevelopmental disorders have been proposed to involve alterations epigenetic regulation, and effects may extend germline cells affect later generations. Weight status DNA methylation, maternal weight before during pregnancy has associated with offspring methylation as well attention-deficit/hyperactivity disorder (ADHD). <h3>Objective</h3> To assess whether a woman's is ADHD in her grandchild. <h3>Design, Setting, Participants</h3> This cohort study analyzed data...
Animal studies have shown that exposure to cigarette smoke during pregnancy can induce neurobehavioral anomalies in multiple subsequent generations. However, little work has examined such effects humans. We the risk of grandchild autism spectrum disorder (ASD) association with grandmother's smoking pregnancy, using data from 53 562 mothers and grandmothers 120 267 grandchildren Nurses' Health Study II. In 1999, II participants children reported on their mothers' smoking. Grandchildren's ASD...
BACKGROUND AND AIM: Per- and polyfluoroalkyl substances (PFAS) have been associated with adverse health impacts for both mother child. Extracellular vesicle particle microRNAs (EVP miRNAs) facilitate maternal-fetal communication during pregnancy complications birth outcomes. However, little is known about the of PFAS on circulating EVP miRNAs pregnancy. METHOD: We conducted a pilot study 50 participants from New Hampshire Birth Cohort Study. Seven 798 were measured in maternal plasma samples...
BACKGROUND AND AIM: Birth to 2 years of age is characterized by dynamic growth processes, which may affect risk chronic diseases, such as cancer and cardiovascular diseases. Although trajectories are more predictive for diseases in later life compared measures at a single time point, most previous studies have used static anthropometric measures. Moreover, there was lack statistical methods that can accommodate the complex relationship between environmental mixture exposures health outcome...
Background/Aims Childhood obesity has become a global epidemic, with 1 in 3 children the United States affected. The etiology of is multifactorial, including genetic, perinatal, dietary, psychosocial, and environmental factors. One potential modifiable risk factors for childhood endocrine disrupting chemicals. Diethylstilbestrol (DES) synthetic estrogen that was prescribed to pregnant women prevent pregnancy loss between 1940s 1970s, but banned its unexpected adverse health effects. Previous...
Background and Aim: Exposure to either metal or perfluoroalkyl substance (PFAS) mixtures during pregnancy has been associated with adverse birth outcomes. However, little is known about the potential joint effects of these two classes chemicals. We aimed investigate joint, index-wise, individual impacts metals PFAS exposures on outcomes in a prospective cohort study using both established novel mixture modeling approaches. Methods: Study participants included 537 mother-child pairs from New...
BACKGROUND AND AIM: Prenatal exposure to endocrine disrupting chemicals, including polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and dioxin-like biphenyls (DL-PCBs), has been hypothesized have detrimental impact on neurodevelopment. However, the effect of prenatal dioxin DL-PCB mixtures neurodevelopment remains largely inconclusive. Therefore, we aimed elucidate associations in utero a mixture with infant by applying novel multi-pollutant methods. METHODS: The...