A5016848802- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Microbial infections and disease research
- COVID-19 and Mental Health
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Circadian rhythm and melatonin
- Adenosine and Purinergic Signaling
- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Renal Transplantation Outcomes and Treatments
- Aquaculture disease management and microbiota
- Cytomegalovirus and herpesvirus research
- Adipokines, Inflammation, and Metabolic Diseases
- Work-Family Balance Challenges
- Entomological Studies and Ecology
- COVID-19 Impact on Reproduction
- Social Issues and Policies in Latin America
- Organ Transplantation Techniques and Outcomes
- Diabetes and associated disorders
- Immune responses and vaccinations
- Public Health and Environmental Issues
- Inflammasome and immune disorders
- Technostress in Professional Settings
- Acute Kidney Injury Research
Universidade de São Paulo
2019-2024
Universidade Cidade de São Paulo
2021
Centro de Biología Molecular Severo Ochoa
2021
Universidad De Santander
2016-2021
Universidad de Santander
2021
University of Massachusetts Chan Medical School
2012-2015
Pontificia Universidad Javeriana
2008-2013
Military University Nueva Granada
2013
Following primary infection, human herpesvirus 6 (HHV-6) establishes a persistent infection for life. HHV-6 reactivation has been associated with transplant rejection, delayed engraftment, encephalitis, muscular dystrophy, and drug-induced hypersensitivity syndrome. The poor understanding of the targets outcome cellular immune response to makes it difficult outline role in disease. To fill this gap, we characterized CD4 T cell responses using peripheral blood mononuclear (PBMC) lines...
Abstract HLA-DM (DM) is a nonclassical MHC class II (MHC II) protein that acts as peptide editor to mediate the exchange of peptides loaded onto during Ag presentation. Although ability DM promote in vitro and vivo well established, role epitope selection still unclear, especially human response infectious disease. In this study, we addressed question context CD4 T cell vaccinia virus. We measured IC50, intrinsic dissociation t1/2, DM-mediated t1/2 for large set derived from major core A10L...
Abstract The search for new therapeutical targets cutaneous melanoma and other cancers is an ongoing task. We expanded this knowledge by evaluating whether opsins, light- thermo-sensing proteins, could display tumor-modulatory effects on cancer. Using different experimental approaches, we show that cell proliferation slower in the absence of Opn4 , compared to WT due impaired cycle progression reduced melanocyte inducing transcription factor ( Mitf ) expression. In vivo tumor KO cells...
Cholesterol-ester transfer protein (CETP) plays a role in atherosclerosis, the inflammatory response to endotoxemia and experimental human sepsis. Functional alterations lipoprotein (LP) metabolism immune cell populations, including macrophages, occur during sepsis may be related comorbidities such as chronic obstructive pulmonary disease (COPD). Macrophages are significantly associated with emphysema, depending on microenvironment, might exhibit an M1 or M2 phenotype. derived from...
Cisplatin is an antineoplastic agent used to treat various tumors. In mammals, it can cause nephrotoxicity, tissue damage, and inflammation. The release of inflammatory mediators leads the recruitment infiltration immune cells, particularly neutrophils, at site often as inducer acute kidney injury (AKI) in experimental models, including zebrafish (Danio rerio), due its accumulation cells. Current protocols larval focus on studying effect AKI but ignore other systematic outcomes. this study,...
Most of humanity is chronically infected with human herpesvirus 6 (HHV-6), viral replication controlled at least in part by a poorly characterized CD4 T cell response. Identification epitopes recognized cells complicated the large size genome and low frequency circulating responding to virus. Here, we present an alternative classical epitope mapping approaches used identify major targets response complex pathogen like HHV-6B. In approach presented here, extracellular virus preparations or...
<b><i>Background:</i></b> Papular urticaria by flea bite is a chronic allergic condition in which clinical improvement may occur at the age of 7 years, thus representing natural model acquired immunologic tolerance humans. The aim this study was to characterize regulatory cells and specific responses antigens CD4<sup>+</sup> T lymphocytes expressing cutaneous migration markers patients with papular caused different disease evolution times....
Melanoma skin cancer is extremely aggressive with increasing incidence and mortality. Among the emerging therapeutic targets in treatment of cancer, family transient receptor potential channels (TRPs) has been reported as a possible pharmacological target. Specifically, ankyrin subfamily, representing TRPA1 channels, can act pro-inflammatory hub. These have already implicated control intracellular metabolism several cell models, but little known about their role immune cells, how it could...
Background Papular urticaria by flea bite (PUFB) is a chronic inflammatory disease in children. The aim of this study was to assess the functional activity IgE protein fractions from body extract, through basophil degranulation PUFB patients and controls.Methods Basophil degranulation, measured overexpression CD63 surface molecules, evaluated flow cytometry samples controls. Cell stimulation performed with three different molecular weight extract using Basotest® modified protocol....
El síndrome respiratorio agudo severo (SARS), cuyo agente causal es el Coronavirus SARS-CoV, surgió en 2003, sin embargo, a finales del 2019, se observó que un nuevo (SARS-CoV-2) causaba una enfermedad similar la influenza, denominada COVID-19 (acrónimo inglés coronavirus disease 2019), cual, presentaba desde síntomas respiratorios leves hasta lesiones pulmonares graves, y algunos casos, cursando con insuficiencia multiorgánica muerte 1,2,3.
Organ transplantation is a life-saving procedure, however predicting graft survival still challenging.Understanding immune-cell pathobiology critical to the development of effective therapies prevent rejection.Over recent years it has become progressively evident that complex nature immune cell behavioral dynamics strongly dependent on cellular metabolism, which in turn, relies competition for nutrients, oxygen and metabolites with other cells microbiota.Furthermore, influence inflammatory...
Introducción: Los departamentos de la Guajira y Cesar son considerados los principales productores ovinos caprinos del país, según censo Instituto Colombiano Agropecuario (ICA) en el año 2015. Estas especies animales revisten interés desde punto vista sanitario, no solo por productos obtenidos ellos, sino también capacidad que tienen ser reservorio diferentes agentes infecciosos. A fecha Colombia se encuentran reportes relacionados con prevalencia infecciosos, como es caso Mycobacterium...
Introducción: Las esporas fúngicas son componentes normales de ambientes externos e internos. La mayoría los hongos presentes en internos saprófitos, porque ellos obtienen lo que necesitan para su metabolismo materiales muertos, materia orgánica o sustratos como madera, papel, pintura, suelo, polvo, piel y alimentos. Adicional al deterioro estos organismos pueden desencadenar áreas almacenamiento material bibliográfico, muchas las respuestas alérgicas individuos susceptibles. De esta manera,...
Introducción: Los departamentos de la Guajira y Cesar son considerados los principales productores ovinos caprinos del país, según censo Instituto Colombiano Agropecuario (ICA) en el año 2015. Estas especies animales revisten interés desde punto vista sanitario, no solo por productos obtenidos ellos, sino también capacidad que tienen ser reservorio diferentes agentes infecciosos. A fecha Colombia se encuentran reportes relacionados con prevalencia infecciosos, como es caso Mycoplasma...
El estudio tuvo como objetivo determinar la prevalencia de Toxoplasma gondii y Mycoplasma agalactiae en ovinos caprinos del sur La Guajira norte Cesar parte establecimiento un perfil serológico estas especies animales región colombiana. Las muestras suero (n=1039) fueron analizadas con kits comerciales ELISA específicos para estos dos patógenos. global encontrada fue 25.1 18.3% T. 0.12 0.8% M. agalactiae, caprinos, respectivamente. Muestras positivas a más frecuentes hembras que machos....