A5101777900- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Eosinophilic Disorders and Syndromes
- Breast Cancer Treatment Studies
- Cancer-related cognitive impairment studies
- Blood Pressure and Hypertension Studies
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Cancer and Skin Lesions
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Platelet Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Multiple and Secondary Primary Cancers
- Peptidase Inhibition and Analysis
- Pediatric health and respiratory diseases
- Geographies of human-animal interactions
Instituto Português de Oncologia de Coimbra Francisco Gentil
2024-2025
Institute of Cardiology
2025
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2023-2024
Weatherford College
2024
Polytechnic Institute of Porto
2023
Centro Hospitalar de Entre o Douro e Vouga E.P.E.
2023
Ricardo (United Kingdom)
2022
Background: Colorectal cancer (CRC) is the third most diagnosed globally and second leading cause of cancer-related deaths. Despite advancements, metastatic CRC (mCRC) has a five-year survival rate below 20%. Next-generation sequencing (NGS) recommended nowadays to guide mCRC treatment; however, its clinical utility when compared with traditional molecular testing in debated due limited improvement cost-effectiveness concerns. Methods: This retrospective study included patients (≥18 years)...
The multitarget oral tyrosine kinase inhibitor sorafenib is an effective first-line treatment option in unresectable hepatocellular carcinoma. Through its mechanism of action, it has been associated with cardiotoxicity, mainly hypertension, which usually low-grade and well-managed behavioral changes antihypertensor adjustment, if needed. Acute, symptomatic heart failure rarely described. We present the case a patient priors arterial dyslipidemia, type 2 diabetes mellitus, non-alcoholic...
INTRODUCTION: In patients with metastatic colorectal cancer (mCRC) without RAS/BRAF somatic variants, first-line anti-EGFR antibodies plus chemotherapy improve survival. Retreatment of responders rechallenge accumulates less evidence for benefit when compared other available third-line treatments. MATERIAL AND METHODS: A unicentric retrospective cohort wild type (wt) mCRC, treated irinotecan/cetuximab within the definition rechallenge, was selected between 2018 and 2023. Liquid biopsy...
Synchronous primary malignancies are uncommon and represent diagnostic therapeutic challenges, particularly for elderly patients with comorbidities. We report the case of a 78-year-old man distinct adenocarcinomas lung pancreas who was successfully treated curative-intent approach. Initially exhibiting unintentional weight loss, asthenia, gastrointestinal complaints, initial workup, which included computed tomography (CT) positron emission tomography/computed (PET/CT), revealed spiculated...
This case report describes the clinical course, diagnosis, and management of a premenopausal woman with history estrogen receptor (ER)-positive human epidermal growth factor 2 (HER2)-positive early breast cancer (EBC) who developed severe thrombocytopenia. After six years diagnosis EBC (treated curative intent), she presented back pain, significant bruising, menorrhagia. During work-up, laboratory tests revealed thrombocytopenia, imaging studies, including computed tomography scan bone...
The distribution of blood pressure (BP) in children and adolescents remains relatively unknown. Thus, it is imperative to ascertain BP at a young age, which constitutes the main objective this registry.Cross-sectional assessment 5381 Portuguese adolescents, mean age 12.50±3.23 years (4-18 years), body mass index (BMI) 19.65±4.00 kg/m(2) (9.37-60.30 kg/m(2)), mostly male (4519), 12.70±3.16 years, with 862 females, 11.44±3.34 years. heart rate were measured three times after 10-min resting...
<ns4:p>Background Breast cancer frequently leads to reduced work capacity and increased absenteeism among working-age women diagnosed with this condition. In study, we aimed assess the effect of CDK4/6i combined aromatase inhibitors (AIs) or fulvestrant on quality life (QoL) activity in a cohort Portuguese patients hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast who started treatment regimen. Methods This unicentric prospective...
<title>Abstract</title> Despite advancements in cancer immunotherapy, most lymphomas remain unresponsive to checkpoint inhibitors. P-selectin glycoprotein ligand-1 (PSGL-1), recently identified as a promoter of T cell exhaustion melanoma murine models, has emerged novel immune protein and promising immunotherapeutic target. In this study, we investigated the potential PSGL-1 antibody targeting B-cell lymphoma. Using allogeneic coculture systems, demonstrated that targeted interventions...
Neuroendocrine carcinoma of the cervix (NECC) is a rare and extremely aggressive disease. Treatment options are scarce (mainly consisting platinum-based chemotherapy combinations), randomized controlled trials lacking, leading to very poor prognosis. It prone early metastasis, often with more than one affected site at diagnosis. The lung, liver, brain, bone most frequent sites. We present case 33-year-old female patient no significant medical history. Postcoital bleeding led diagnosis human...
Background: Colorectal cancer (CRC) is the third most diagnosed globally and second leading cause of cancer-related deaths. Despite advancements, metastatic CRC (mCRC) has a five-year survival rate below 20%. Next-generation sequencing (NGS) can identify rare actionable mutations assess tumour mutational burden (TMB), but its clinical utility in mCRC debated due to limited improvement cost-effectiveness concerns. Methods: This retrospective study included patients (&ge;18 years) treated...
Background: Colorectal cancer (CRC) is the third most diagnosed globally and second leading cause of cancer-related deaths. Despite advancements, metastatic CRC (mCRC) has a five-year survival rate below 20%. Next-generation sequencing (NGS) recommended nowadays to guide mCRC treatment, however its clinical utility when compared with traditional molecular testing in debated due limited improvement cost-effectiveness concerns. Methods: This retrospective study included patients (&ge;18...
Fibrotic Hypersensitivity Pneumonitis (fHP) often presents a progressive fibrosing (PF) phenotype. Elevated levels of both circulating monocytes and alveolar macrophages have been pointed to play role in the pathogenesis idiopathic pulmonary fibrosis, but no substantive data exists regarding their contribution on PF-HP. We performed multicenter analysis retrospective cohort 210 patients with fHP determine predicting variables early (<2 years) PF phenotype or death. The relationship...
An 86th years old woman presented to the emergency room with status post syncope, dysarthria and prostration. Personal history of essential hypertension a hip replacement. Physical examination was unremarkable: Glasgow coma scale 15, without neurologic deficits. Brain CT revealed frontoparietal mass bone destruction, but oedema or effect. Within thirty minutes, she started an acute confusional aggressiveness status. Complete body had no alterations. Had repeated brain that massive expansive...
1554 Background: Precision oncology aims to guide patient (pts) treatment decisions by matching biological features with available drugs. Extensive genomic analysis allows identify an actionable alteration in 40-60% of patients. In a recent study 50 pts advanced refractory diseases included PROFILER (NCT01774409), whole exome and fusion transcripts had limited value over 90-tumor gene panel (TGP) increase molecular-based recommendations (MBTR). Herein, we evaluated the feasibility, same...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Outdoor activities with dogs are known to be physically and mentally beneficial them their owners, but less is about circulation in public spaces. This study aimed understand the effects of dog-owner dyad’s visits an interactive exhibition on dogs’ behaviour perceptions visitors, staff. 38 dyads were studied four rooms (Angry Birds, Dòing, Explora Access) over eight periods 90 minutes during which animals’ was sampled, questionnaires filled out by Results showed that a very high percentage...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)