A5029285849- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Animal Virus Infections Studies
- Arsenic contamination and mitigation
- Mercury impact and mitigation studies
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Cell death mechanisms and regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Phytochemicals and Medicinal Plants
- Biochemical Acid Research Studies
- DNA Repair Mechanisms
- Nanoparticles: synthesis and applications
- Therapeutic Uses of Natural Elements
- Melanoma and MAPK Pathways
- SARS-CoV-2 and COVID-19 Research
- Aluminum toxicity and tolerance in plants and animals
- Selenium in Biological Systems
- PARP inhibition in cancer therapy
- Mesenchymal stem cell research
- Viral gastroenteritis research and epidemiology
Zhejiang A & F University
2020-2022
China International Science and Technology Cooperation
2022
Yangzhou University
2016-2020
Ministry of Education of the People's Republic of China
2019-2020
Emory University
2019
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly prevalent endemic swine pathogen that causes significant economic losses to the global industry. Selenium nanoparticles (SeNPs) have attracted increasing attention in biomedical field, given their antiviral effects. This study aimed investigate inhibitory effect of chitosan-coated SeNPs (CS-SeNPs) on PRRSV replication.In this study, CS-SeNPs were synthesized by chemical reduction characterized assessing morphology, size...
We designed this study to investigate whether cadmium induces caspase-independent apoptosis and the relationship between caspase-dependent apoptotic pathways. Cadmium (1.25-2.5 μM) induced oxidative stress in rat proximal tubular (rPT) cells, as seen reactive oxygen species levels; N-acetylcysteine prevented this. Cyclosporin A (CsA) mitochondrial permeability transition pore opening apoptosis; there was ultrastructural disruption, cytochrome c (cyt c) translocation cytoplasm, subsequent...
The Fas/FasL signaling pathway is one of the primary apoptosis pathways, but involvement and regulatory mechanism this by autophagy remain unclear. Here we demonstrated that cadmium (Cd) activated in rat proximal tubular (rPT) cells; was accompanied simultaneous activation resulted reduced apoptosis. In model, induced through RAPA further protects against antiapoptotic effect blocked 3-MA, an inhibitor. interactions between Beclin-1 Fas, FasL, FADD, caspase-8 BID/tBID were relatively weak,...
Parthanatos is a newly discovered form of PARP-1-dependent programmed cell death. It has been reported to play an important role in several cancer or tumour cells; however, few studies have performed normal cells. Cadmium highly toxic pollutant and induce autophagy apoptosis multiple types. Although cadmium toxicity induces death, the underlying mechanism not fully understood. Therefore, this study we aimed investigate -induced damage using rat proximal tubular line NRK-52E primary (rPT) Our...
The harm of nonalcoholic fatty liver disease to human health is increasing, which calls for urgent prevention and treatment the disease. Isoorientin an effective ingredient Chinese herbal medicine with anti-inflammatory antioxidant effects. However, effect isoorientin in still unclear. In this study, combined vivo vitro experiments, through pathological observation, flow cytometry, immunofluorescence western blot analysis explore role steatosis reveal its molecular mechanism. results...
Abstract Recent studies have shown that monounsaturated oleic acid induces steatosis in cultured hepatocyte the form of nonalcoholic fatty liver disease models vitro. However, underlying mechanism development is not completely understood. Therefore, we investigated molecular and role mitogen‐activated protein kinase (MAPK)/toll‐like receptor 4‐related (TLR4) expression this study. Rat cells were subjected to different concentrations (1.2‐2.4 mM) for 24 hours. The cell morphological injury...
Heavy metal pollution is a problem that cannot be ignored. Due to the prevalence of cadmium in environment and its harmful effects on humans, has become research hotspot recently. The mechanism cadmium-induced toxicity also drawn much attention most studies have been conducted using whole cells, but toxicological remains unclear. In this study, we aimed obtain NRK-52E cells at different growth stages by various methods analyze differences toxicity. results show sensitivity each phase was...
The Large Conductance Ca 2+ Activated Potassium (BK) Channels plays an important role in renal potassium secretion. G‐protein pathway suppressor 2 (GPS2) is a multifunctional protein and transcriptional regulation factor that involved the mitogen‐activated kinase (MAPK) signaling pathway. We have previously reported WNK4 inhibits BK channel activity by stimulating ERK1/2 p38 pathways. recently shown GPS2 enhances its expression reducing signaling‐mediated degradation of channel. therefore...
Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly prevalent endemic swine pathogen that can cause significant economic losses to the global industry. Host-targeted antiviral drugs have been developed as new strategy for therapy. In this regard, selenium nanoparticles (SeNPs) attracted increasing attention in biomedical field, given their effects. The purpose of study was investigate whether chitosan-coated SeNPs (CS-SeNPs) could affect PRRSV...