A5044895008- Cutaneous Melanoma Detection and Management
- Sarcoma Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Pneumothorax, Barotrauma, Emphysema
- interferon and immune responses
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- Neuroblastoma Research and Treatments
- Barrier Structure and Function Studies
- Cancer and Skin Lesions
- Toxin Mechanisms and Immunotoxins
- Wnt/β-catenin signaling in development and cancer
- Pleural and Pulmonary Diseases
- Viral Infections and Vectors
- T-cell and B-cell Immunology
- Occupational and environmental lung diseases
- Bone Tumor Diagnosis and Treatments
- Axon Guidance and Neuronal Signaling
- Cutaneous lymphoproliferative disorders research
- Colorectal Cancer Surgical Treatments
- Advanced Biosensing Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Neurofibromatosis and Schwannoma Cases
- Nonmelanoma Skin Cancer Studies
- Neuroendocrine Tumor Research Advances
University Medical Center Hamburg-Eppendorf
2024-2025
Universität Hamburg
2024-2025
Düzce Üniversitesi
2020-2022
Sivas State Hospital
2022
Occludin is a key component of tight junctions. Reduced occludin expression has been linked to cancer progression in individual tumor types, but comprehensive and standardized analysis across human types lacking. To study the prevalence clinical relevance cancer, tissue microarray containing 16,870 samples from 148 different 608 76 normal was analyzed by immunohistochemistry. immunostaining observed 10,746 (76.6%) 14,017 analyzable tumors, including 18.9% with weak, 16.2% moderate, 41.6%...
Stimulator of interferon genes protein (STING) activates the immune response in inflammatory cells. STING expression cancer cells is less well characterized, but agonists are currently being evaluated as anticancer drugs. A tissue microarray containing 18,001 samples from 139 different tumor types was analyzed for by immunohistochemistry. STING-positive were found 130 (93.5%) entities. The highest positivity rates occurred squamous cell carcinomas (up to 96%); malignant mesothelioma...
Background/Objectives: Trefoil factor 1 (TFF1) plays a role in the mucus barrier. Methods: To evaluate prevalence of TFF1 expression cancer, tissue microarray containing 18,878 samples from 149 tumor types and 608 76 normal was analyzed through immunohistochemistry (IHC). Results: staining detectable 65 categories. The highest rates positivity were found mucinous ovarian carcinomas (76.2%), colorectal adenomas adenocarcinomas (47.1–75%), breast neoplasms (up to 72.9%), bilio-pancreatic...
ABSTRACT Backround Anterior gradient 2 (AGR2) is a resident endoplasmic reticulum (ER) protein with vital role in embryonal development, mucus maturation, tissue regeneration, and wound healing. Methods To determine the prevalence clinical significance of AGR2 expression cancer, microarray containing 14,966 tumors from 134 different tumor types subtypes as well 608 samples 76 normal was analyzed by immunohistochemistry (IHC). Results positivity found 103 categories, 83 categories contained...
Peripheral nerve sheath tumors may occur sporadically or related to neurofibromatosis (NF). Unless the mechanisms of tumorigenesis in NF malignant peripheral (MPNST) are better understood, it remained unclear sporadic cases. We aimed investigate genetic route for malignancy both individuals with NF-1 and ones open a way targeted therapies future. investigated role HER2 Dual ISH DNA Probe Cocktail test, BRAF mutation (exon 15) TERT promoter frequency Sanger sequencing method respectively 25...
Objective: Colorectal cancers are in third place terms of incidence and second mortality. This study aims to type the polyps detected during colonoscopy according Paris classification, perform polypectomy with appropriate technique, classify them as histopathological, determine presence dysplasia, review risk status colorectal cancer. Material Method: Our is a retrospective presented one-year 124 patients who were found have colonic due colonoscopy, underwent whose histopathological...
Claudin-3 (CLDN3) participates in the formation of tight-junctions (TJs) that regulate intercellular permeability. Altered CLDN3 expression has been linked to tumor progression multiple types. Despite its widespread normal epithelial cells, is considered an attractive drug target candidate, since it may be more accessible cancer cells than due their less orchestrated cell growth.
CD123-positive plasmacytoid dendrocytes are prominent in the infiltrate of cutaneous lupus erythematous.To determine significance CD123 immunostain, which labels dendritic cells (PDC), erythematous (CLE), polymorphous light eruption (PLE), pityriasis rosea (PR) and mycosis fungoides (MF).A total 76 cases, including MF (n = 27), CLE 19), PR PLE 11), were included study after reviewing their diagnostic clinical features pathologic findings. The primary antibody against was performed all...
Basal cell carcinoma (BCC) is the most common malignant tumor in humans. It can be seen anywhere skin, although more than 80% occurs areas exposed to sun, such as head and neck . Chronic exposure sunlight thought main etiological factor. Although risk of metastasis BCC very low, may locally aggressive cause tissue destruction. We present three cases atypical locations, waist region, lateral femoral perineal region No predisposing factor terms etiology was encountered these patients'...
Receptor tyrosine kinase pathway is frequently searched for cancer causing mutations in tumors. Emerging targeted therapies are gleam of hope them. Infiltrating urothelial carcinoma can have many morphological aspects according to their differentiation/variants. To evaluate KRAS, BRAF, and PIK3CA HER2, EGFR, p16 expression, we divided carcinomas into two groups: differentiated/variants (n = 12) conventional 12). We compared results with clinical, demographic, histopathologic features...
Artificial intelligence is a rising star in pathology. Applying artificial methods to pathology gleam of hope reduce the workload pathologists. Diagnosis melanocytic lesions can be challenging. There are that cannot clearly addressed, not only for general pathologists, but even dermatopathologists. Can help us with this dilemmas? To find an answer we aimed measure contribution differential diagnosis lesions. We used machine learning first part and deep second order intelligence's...