A5081556500- HER2/EGFR in Cancer Research
- Neuroblastoma Research and Treatments
- Enzyme function and inhibition
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Wnt/β-catenin signaling in development and cancer
- Peptidase Inhibition and Analysis
- Testicular diseases and treatments
- Hemoglobin structure and function
- Estrogen and related hormone effects
- Gene expression and cancer classification
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Axon Guidance and Neuronal Signaling
- Ion channel regulation and function
- Cancer-related molecular mechanisms research
- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Turtle Biology and Conservation
- Barrier Structure and Function Studies
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
University Medical Center Hamburg-Eppendorf
2015-2025
Universität Hamburg
2015-2025
Mercedes-Benz (Germany)
2009
Cadherin-17 (CDH17) is a membranous cell adhesion protein predominantly expressed in intestinal epithelial cells. CDH17 therefore considered possible diagnostic and therapeutic target. This study was to comprehensively determine the expression of cancer further assess utility immunohistochemistry (IHC). A tissue microarray containing 14,948 interpretable samples from 150 different tumor types subtypes as well 76 normal analyzed by IHC. In tissues, staining seen epithelium intestine...
Occludin is a key component of tight junctions. Reduced occludin expression has been linked to cancer progression in individual tumor types, but comprehensive and standardized analysis across human types lacking. To study the prevalence clinical relevance cancer, tissue microarray containing 16,870 samples from 148 different 608 76 normal was analyzed by immunohistochemistry. immunostaining observed 10,746 (76.6%) 14,017 analyzable tumors, including 18.9% with weak, 16.2% moderate, 41.6%...
Background: The complete loss of S-methyl-5′-thioadenosine phosphorylase (MTAP) expression, often due to homozygous 9p21 deletion, creates a druggable vulnerability in cancer cells. Methods: A total 769 primary pancreatic ductal adenocarcinomas were analyzed on tissue microarrays with MTAP immunohistochemistry (IHC) and fluorescence situ hybridization (FISH). Intratumoral heterogeneity was assessed “heterogeneity” TMA containing up nine samples from different areas 236 tumor nodal...
Carbonic anhydrase IX (CAIX) is involved in pathological processes including tumorgenicity, metastases and poor survival solid tumors. Twenty-two neuroblastoma samples of patients who were surgically treated at the University Medical Center Hamburg-Eppendorf evaluated immunohistochemically for expression CAIX. Results correlated with clinical parameters outcome. Neuroblastoma Kelly SH-EP-Tet-21/N cells examined CAIX inhibited specific inhibitors, FC5-207A FC8-325A. 32% tumors expressed This...
Prostein (P501S), also termed solute carrier family 45 member 3 (SLC45A3) is an androgen regulated protein which preferentially expressed in prostate epithelial cells. Because of its frequent expression cancer, prostein was suggested a diagnostic cancer marker.
Abstract Background Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2) regulate alternative events of various pre-mRNAs. Some these targets play a role in cancer-associated processes, including cytoskeleton reorganization DNA-repair processes. This study was undertaken to estimate the impact ESRP1 ESRP2 alterations on prostate cancer patient prognosis. Methods A tissue microarray made from 17,747 individual samples with comprehensive, pathological, clinical molecular data...
The hypoxic tumour microenvironment of solid tumours represents an important starting point for modulating progression and metastatic spread. Carbonic anhydrase IX (CAIX) is a known HIF-1α-dependent key player in maintaining cell pH conditions under hypoxia. We show that CAIX strongly expressed esophageal carcinoma tissues. hypothesize moderate expression facilitates metastases thereby worsens prognosis. Selective inhibition by specific inhibitors knockdown effectively inhibit proliferation...
Class III β‑tubulin (TUBB3) is a component of microtubules neuronal cells that upregulated in various cancer entities. To better understand the role TUBB3 upper gastrointestinal tract types, present study assessed expression tissue microarrays including 189 gastric and 428 esophageal cancer. was detected 62.4% cancer, 73.8% adenocarcinoma 88.7% squamous cell while control samples normal epithelium were TUBB3‑negative. positivity not associated with International Union Against Cancer...
Claudin-3 (CLDN3) participates in the formation of tight-junctions (TJs) that regulate intercellular permeability. Altered CLDN3 expression has been linked to tumor progression multiple types. Despite its widespread normal epithelial cells, is considered an attractive drug target candidate, since it may be more accessible cancer cells than due their less orchestrated cell growth.