A5069579997- Malaria Research and Control
- Animal Nutrition and Physiology
- Mosquito-borne diseases and control
- Coccidia and coccidiosis research
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Drug-Induced Hepatotoxicity and Protection
- Viral gastroenteritis research and epidemiology
- Helminth infection and control
- Redox biology and oxidative stress
- Parasitic Infections and Diagnostics
- Parasites and Host Interactions
- Veterinary medicine and infectious diseases
- Selenium in Biological Systems
- Animal Virus Infections Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Aquaculture disease management and microbiota
- Trace Elements in Health
- Insect and Pesticide Research
- Traditional and Medicinal Uses of Annonaceae
- Complement system in diseases
- Eosinophilic Disorders and Syndromes
- Diverse Scientific Research Studies
- Chemokine receptors and signaling
- Toxoplasma gondii Research Studies
Okayama University
2013-2025
Okayama University of Science
2014-2022
RMIT University
2004-2014
Gunma University
2002-2013
Saitama International Medical Center
2000-2005
The University of Tokyo
1999-2003
Japan Science and Technology Agency
2003
Nagasaki University
2001
Research Medical Center
2001
Previous intervention studies have shown that the most effective agents used in treatment of malaria were isolated from natural sources. Plants consumed by non‑human primates serve as potential drug sources for human disease management due to similarities anatomy, physiology and characteristics. The present study investigated antiplasmodial properties primate‑consumed plant, Schima wallichii (S. wallichii) Korth. (family Theaceae), which has already been reported several biological...
Molecular biological techniques have enabled the accurate identification of avian Eimeria parasite, however, preparation PCR template remains a bottleneck due to contaminants from feces and robust oocyst's wall resistant chemical mechanical force. Generally, involves three main steps: (1) pretreatment oocysts; (2) disruption (3) purification genomic DNA. We prepared templates both unsporulated sporulated E. tenella oocysts using various protocols, followed by species-specific define limit...
Abstract Background In the Philippines, malaria morbidity and mortality have decreased since 1990s by effective control. Several epidemiological surveys been performed in country, but characteristics of Plasmodium falciparum populations are not yet fully understood. this study, genetic structure P. Philippines was examined. Methods Population analyses based on polymorphisms 10 microsatellite loci parasite were conducted 92 isolates from three provinces (Kalinga, Palawan, Davao del Norte)...
VAMP7 or tetanus neurotoxin‐insensitive vesicle‐ associated membrane protein (TI‐VAMP) has been proposed to regulate apical transport in polarized epithelial cells, axonal neurons and lysosomal exocytosis. To investigate the function of vivo , we generated knockout mice. Here, show that mice are indistinguishable from control display a similar localization proteins kidney small intestine nervous system. Neurite outgrowth cultured mutant hippocampal was reduced neurons. However, exocytosis...
Abstract Acoel flatworms possess epidermal sensory-receptor cells on their body surfaces and exhibit behavioral repertoires such as geotaxis phototaxis. sensory receptors should be mechanical and/or chemical receptors; however, the mechanisms of reception have not been elucidated. We examined three-dimensional relationship between innervation in an acoel flatworm, Praesagittifera naikaiensis . The distribution was different ventral dorsal sides worms. nervous system mainly composed a...
Abstract Infections by gastrointestinal parasites are found in a variety of animals worldwide. For the diagnosis such infections, flotation method is commonly used to detect parasitic microorganisms, as oocysts or eggs, feces. Instead adding solution after final centrifugation step and using cover slip collect parasites, wire loop for recovery organisms has been reported one alternative methods. However, rates microorganisms from have not analysed. In present study, utility with use 8 mm...
After parturition, cows frequently develop uterine bacterial infections, resulting in the onset of endometritis. To eliminate bacteria, bovine endometrial cells secrete chemokines, such as IL-6 and MCP1, which attract macrophages (MΦs) to subepithelial stroma. These attracted MΦs are not only involved elimination but also orchestration inflammation tissue repair. immune responses aid recovery from endometritis; however, endometritis takes longer summer than any other season. Based on these...
Plasmodium falciparum -infected erythrocytes (pRBCs) adhere to the endothelium via receptors expressed on surface of vascular endothelial cells (EC) and sequester in microvasculature several organs block blood circulation. The sequestration, which involves receptors, may be related severity malaria. Here, we report that pRBCs bind membrane-bound form Fractalkine/CX 3 CL1 (FKN), is EC various organs. adhered FKN cDNA-transfected Chinese hamster ovary (CHO-FKN cells). Both recombinant human...
Plasmodium falciparum has for some time been developing resistance against known anti-malarial drugs, and therefore a new drug is urgently needed. Selenium (Se), an essential trace element, in the form of inorganic Se, selenite (SeO32-), reported to have anti-plasmodial effect, but its mechanism still unclear. In present study, we evaluated effect several Se compounds P. vitro. The was analysed their apoptosis-inducing activity by morphological observation, DNA fragmentation assay...
One of the most characteristic clinical features in cutaneous leishmaniasis is development nodules followed by ulcerations at site infection. Leishmania amazonensis-infected mice show similar ulcerative lesions. Leishmania-infected severe combined immunodeficiency (SCID) mice, however, have been shown to develop nonulcerative nodules. In present study, roles T cells ulceration were examined using SCID cell reconstitution experiments. After nodules, inoculated with splenocytes from either or...
This study aimed to evaluate the microbial compositions and gene expression related inflammation in dextran sodium sulfate (DSS)-induced acute colitis effect of mulberry supplementation. Male BALB/c mice received a diet supplemented with juice freeze-dried powder (MFP) or not for 3 weeks. After weeks, water containing 5% (w/v) DSS 1 week. The disease activity index score fed MFP was significantly decreased. A significant decrease Bifidobacterium spp. Clostridium perfringens subgroup observed...
The emergence and spread of drug-resistant Plasmodium falciparum continue to pose problems in malaria chemotherapy. Therefore, it is necessary identify new antimalarial drugs therapeutic strategies. In the present study, activity a heat-treated form amphotericin B (HT-AMB) against P. was evaluated. efficacy toxicity HT-AMB were also compared with those standard formulation (AMB). showed significant chloroquine-resistant strain (strain K-1) chloroquine-susceptible FCR-3) vitro. 50% inhibitory...
There have been no reports of the prevalence Eimeria spp. in poultry breeding farms Japan unlike those broiler farms. From 2017 to 2018, we examined on by oocyst morphology and PCR analyses. A total 143 samples was collected from 37 21 prefectures Japan. We detected oocysts seven species at 34 PCR, identified E. brunetti 51.5% found be positive for Eimeria. The differences identification between assay methods were pronounced maxima necatrix. confirmed that molecular tools more suitable...
We report a 68-year-old woman with severe falciparum malaria contracted in Tanzania. She presented high parasitemia and was treated successfully intravenous artesunate, qinghaosu derivative, aggressive supportive therapy. developed hemolytic anemia jaundice on day 11 blood transfusion required. This case illustrates that artesunate has excellent antimalarial activity rapid efficacy no adverse effect but conventional therapy is still important the treatment of malaria.