A5017045575- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Cervical Cancer and HPV Research
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Sex work and related issues
- Mosquito-borne diseases and control
- Poxvirus research and outbreaks
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- Mycobacterium research and diagnosis
- Virology and Viral Diseases
- Viral-associated cancers and disorders
- Bacillus and Francisella bacterial research
- Genital Health and Disease
- Colorectal and Anal Carcinomas
- Herpesvirus Infections and Treatments
- Malaria Research and Control
- Hepatitis B Virus Studies
- HIV, TB, and STIs Epidemiology
- Brucella: diagnosis, epidemiology, treatment
- Burkholderia infections and melioidosis
- Amoebic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
Kobe Asahi Hospital
2013
Tokyo Women's Medical University
2002-2009
Tokyo Metropolitan Komagome Hospital
2006-2007
National Institute of Infectious Diseases
2006
Tokyo Women's Medical University Hospital
2002
To describe the clinical features of dengue cases in Japan, a retrospective study was conducted on 62 laboratory-confirmed Japanese presented to Tokyo Metropolitan Komagome Hospital between 1985 and 2000. Age distribution from 18 years old (mean, 31.5 years). All were imported abroad diagnosed as fever. Clinical manifestations included fever (100%), headache (90%), skin rash (82%). Laboratory examinations revealed leukocytopenia (71%), thrombocytopenia (57%), elevated levels serum aspartate...
Abstract Background Since May 2022, the incidence of mpox cases has surged outside endemic regions. Although vaccination remains pivotal in prevention, data on LC16m8, a third-generation smallpox vaccine, are scant. We provided LC16m8 pre-exposure prophylaxis opportunities to high-risk individuals, including those with HIV, and conducted randomized controlled trial assess LC16m8’s effectiveness prevention safety. Methods Our multicenter open-label enrolled men women aged ≥18 years at high...
Abstract Background This randomized controlled trial provided LC16m8 pre-exposure prophylaxis to high-risk individuals assess its efficacy for mpox prevention, safety, and immunogenicity. Methods multicenter, randomized, open-label enrolled men women aged ≥18 years at high risk of mpox. Participants were randomly assigned 1:1 early- or late-vaccination groups. The primary endpoint was vaccine (VE) against Secondary endpoints included VE severe mpox, symptoms, “take” incidence, adverse events...
Abstract Background The incidence of mpox cases has surged outside endemic regions since May 2022. However, data regarding the safety and efficacy LC16m8 vaccine are limited. This study provided opportunities for pre-exposure prophylaxis to high-risk individuals conducted a randomized controlled trial assess effectiveness in prevention. Methods multicenter, randomized, open-label enrolled men women aged ≥18 with high risk. Participants were randomly assigned 1:1 early or late vaccination...
BackgroundWhether tenofovir nephrotoxicity is reversible after its withdrawal unknown. Furthermore, there are no data on the viral efficacy of raltegravir (RAL) plus ritonavir-boosted Darunavir (DRV/r) in patients with suppressed load. MethodsThis multicenter, randomized trial compared renal function and load treated RAL+DRV/r lopinavir (LPV/r) tenofovir/emtricitabine (TVD), who had been previously LPV/r+TVD. The primary endpoint was proportion >10% improvement estimated glomerular...
ABSTRACT A survey of HIV-1 strains circulating in the Tokyo-Kanagawa metropolitan area Japan during 2004 to 2011 ( n = 477) identified six Japanese males (patients 1 6), who harbored viruses with genome segments derived from a distinct CRF01_AE variant uniquely found among men have sex (MSM) China (designated CN.MSM.01-1). These HIV infections were diagnosed 2010 and MSM (3 75) unknown risk factors 63) differed vast majority Japan, which are overwhelmingly characterized by subtype B (239 246...
Brucellosis is the most common zoonosis worldwide, with more than 500,000 new human cases annually. Although brucellosis primarily transmitted to humans through consumption of unpasteurized dairy products contaminated Brucella species, several reports have indicated that may be from a man his female partner. It has been suggested sexual intercourse means transmission in these cases. Here, we describe an additional case probable person‐to‐person melitensis elderly couple. A previously...
In recent years, syphilis notifications have increased dramatically in Japan. We carried out molecular typing and macrolide resistance analyses of Treponema pallidum subsp. samples collected from patients at four clinics a hospital Tokyo Osaka prefectures 2017. The resistant strain type 14d/f (SS14-like clade) was found significantly more cases among heterosexuals than those men who sex with (MSM); i.e., 79% (31/39) the strains were compared to 37% (7/19) MSM (odds ratio [OR], 6.6; 95%...
Accurate diagnosis of earlier HIV infection is essential for treatment and prevention. Currently, confirmation tests in Japan are performed using Western blot (WB), but WB has several limitations including low sensitivity cross-reactivity between HIV-1 HIV-2 antibodies. To address these problems, a new testing algorithm more reliable HIV-1/2 differentiation assay required. The Bio-Rad Geenius Confirmatory Assay (Geenius) recently been approved recommended use the revised guidelines by Center...
Patients with anorexia nervosa (AN) seldom present infectious illness, despite malnutrition-induced immunodeficiency. We described two young women who had a long-standing history of severe emaciation and pulmonary or lymph node tuberculosis discovered during the treatment AN. Both patients reported positive BCG vaccination. Contact tracing failed to reveal sources infection, although was considered transferred. Since decline notification rates for have been stagnant outbreaks in schools...
Abstract Objective Pulmonary infection with a rare atypical mycobacterium, Mycobacterium szulgai , was discovered during the treatment of anorexia nervosa in 21‐year‐old Japanese woman without preexisting pulmonary disease. She had long history low body weight below 35kg. Methods On admission, she examined. weighed 23kg and presented hypoproteinemia, decreased levels rapid turnover proteins, liver dysfunction, serum level insulin‐like growth factor‐I. Results Although neither clinical...
We report a 68-year-old woman with severe falciparum malaria contracted in Tanzania. She presented high parasitemia and was treated successfully intravenous artesunate, qinghaosu derivative, aggressive supportive therapy. developed hemolytic anemia jaundice on day 11 blood transfusion required. This case illustrates that artesunate has excellent antimalarial activity rapid efficacy no adverse effect but conventional therapy is still important the treatment of malaria.
A 30-year-old homosexual Japanese man had fourteen days of fever, malaise, appetite loss, sore throat, and four diarrhea slightly congested eyes before he developed a skin eruption. He presented with measles-like exanthems on his face, trunk, extremities. Deep red enanthems were seen left buccal mucosa opposite the premolar teeth, whitish gingival mucosa. HIV RNA was detected at high concentration 5.8 × 106 copies / ml in serum. Cerebrospinal fluid examination revealed aseptic meningitis...
The rare hepatitis B virus (HBV) genotype G (HBV/G) coinfects HIV-1-positive individuals along with HBV/A and generates recombinants. However, the circulation of HBV A/G recombinants remains poorly understood. This molecular epidemiologic study examined in Japanese men who have sex (MSM). Initially, blood specimens submitted for confirmatory tests HIV infection Osaka Tokyo, Japan, from 2006 to 2013 were HIV-1, screened HBV. Among 817 individuals, HBsAg was detected 59 specimens; these,...
ELISA 法を測定原理とし,抗 HIV-1 抗体,抗 HIV-2 抗体およびHIV-1 p24 抗原を同時検出可能な HIV スクリーニング検査試薬(ジェンスクリーン Ag-Ab ULT,以下ジェンスクリーン ULT と略)について,感度,特異性等の性能評価を行うとともに,感染初期検出感度および 抗原検出感度について,他の 抗原抗体同時検出試薬3 法(アーキテクト・ Ag/Ab コンボアッセイ,以下アーキテクトと略;バイダスアッセイキット DUO II,以下バイダス II と略;ジェンスクリーン Ag-Ab,ジェンスクリーン の以前の型,以下旧試薬と略)との比較検討を行った.HIV 抗体陽性血漿 200 検体および 陰性血漿 1,000 検体を用いて検討した結果,ジェンスクリーン は感度,特異性ともに 100% であった.各 ジェノタイプとの反応性は グループ M のサブタイプ A,B,B',C,D,F,G,B/D,CRF01_AE,グループ O,HIV-2 の検出が可能であった.感染初期セロコンバージョンパネル 10...
Background: In the US and Europe, human immunodeficiency virus (HIV)-seropositive patients who do not have acquired syndrome (AIDS) papillomavirus (HPV) infection in anal canal a significantly increased risk of developing cancer.Examination ablation using high-resolution anoscope (HRA) are widely performed for treatment high-grade intraepithelial neoplasm (HGAIN), precancerous condition.The increasing cancer by HPV is concern also Japan other Asian countries, but systematic examination...
In Japan, syphilis notifications have increased. Men who sex with men (MSM) in Tokyo contributed substantially to the increase notifications. We thus aimed determine correlates of incident among them.MSM attended a clinic that serves sexual minorities were recruited case-control study 2015. A case was seropositive for primary/secondary/asymptomatic at enrolment visit and seronegative prior or had oral ulcers positive Treponema pallidum DNA enrolment. For each case, two controls selected....
Purpose: The incidence of invasive anal cancer (IAC) has been increasing among human immunodeficiency virus (HIV)-positive men who have sex with (MSM). Although cytological diagnosis is the modality choice for screening cases IAC, it associated lower sensitivity and specificity. Therefore, present study aimed to evaluate new signs papillomavirus (HPV) infection that may contribute improving cytology. Methods: Anal cytology HPV testing were performed using SurePath liquid-based on samples...