A5042777971- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Cancer therapeutics and mechanisms
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- HIV/AIDS drug development and treatment
- Foot and Ankle Surgery
- Healthcare and Venom Research
- Engineering Applied Research
- Biomedical Text Mining and Ontologies
- Tendon Structure and Treatment
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Traditional Chinese Medicine Studies
- Occupational and environmental lung diseases
- Phenothiazines and Benzothiazines Synthesis and Activities
- Musculoskeletal synovial abnormalities and treatments
- Autophagy in Disease and Therapy
- SARS-CoV-2 detection and testing
- Photodynamic Therapy Research Studies
- Pneumonia and Respiratory Infections
Masan National Tuberculosis Hospital
2008-2023
International Tuberculosis Research Center
2008
Data on severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) delta variant virulence are insufficient. We retrospectively compared the clinical features of adult coronavirus disease 2019 (COVID-19) patients without risk factors for COVID-19 who entered residential treatment centers (RTCs) before and after outbreak.
Abstract Background Since 1 September 2016, bedaquiline and delamanid have been administered for the treatment of patients with multidrug-resistant/rifampicin-resistant tuberculosis after official approval in South Korea. This study aimed to assess compare final outcomes who received those delamanid. Methods is a nationwide cohort whom or was from 2016 28 February 2018, receiving Patients were classified into group according first used drug. We evaluated compared between groups. Results...
To evaluate the clinical efficacy of pulmonary resection and postoperative use a first-line drug regimen for patients with well-localized, cavitary multidrug-resistant tuberculosis (MDR-TB) extensively drug-resistant (XDR-TB).This was prospective case study set in National Masan Tuberculosis Hospital Masan, Republic Korea. From February 1998 to May 2004, 19 MDR-TB or XDR-TB were enrolled followed prospectively through April 2007. After radical surgical resection, treated anti-tuberculous...
Delamanid is a new anti-TB drug, but few data exist on its use outside clinical trials. The purpose of this study was to evaluate the efficacy as well safety and tolerability delamanid-containing regimen for 24 weeks in treatment MDR- XDR-TB.We performed retrospective cohort among patients with MDR/XDR-TB who were treated seven hospitals South Korea.A total 32 MDR-TB, which 6 (18.8%) XDR-TB, included all completed delamanid treatment. Of 19 (59.4%) had positive culture sputum at initiation...
The objective of this study was to evaluate the efficacy and safety sequential use bedaquiline (Bdq) delamanid (Dlm) in patients with multidrug-resistant tuberculosis (MDR-TB) limited treatment options.This evaluated 74 MDR-TB treated between March 2016 December 2018 Bdq followed by Dlm (n = 22), or vice versa (n= 52), combined optimized background regimens.The mean age participants 49.0 ± 15.8 years. Fifty-one (68.9%) were male. Fluoroquinolone resistance identified 54 (72.9%) patients,...
BACKGROUND The purpose of this study was to evaluate the current status and trends in coverage molecular drug susceptibility testing (mDST), impact mDST on time multidrug-resistant tuberculosis (MDR-TB) treatment initiation Korea. METHODS We included confirmed rifampin-resistant (RR)/MDR-TB patients who submitted application forms for novel uses National TB Expert Review Committee from September 1, 2016 November 30, 2019. retrospectively reviewed their medical records. RESULTS Of 621...
SETTING: This was a nationwide cohort study. OBJECTIVE: To assess the treatment outcomes in patients with multidrug-resistant TB (MDR-TB) who underwent guided by national expert review committee South Korea. DESIGN: We enrolled all MDR-TB submitted for approval use of new drugs, including bedaquiline and delamanid, from 2016 to 2019. Patients were classified into two groups: those on drugs not drugs. compared final between groups analysed prognostic factors. RESULTS: Of total 785 patients,...
Background: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant (XDR-TB) are serious threats to worldwide control, but the national burden trends of infectious spread largely unknown.Methods: We retrospectively reviewed results sensitivity tests medical records patients that were diagnosed with culture-confirmed pulmonary admitted National Masan Tuberculosis Hospital between 2001 2005.Results: From 2005, proportion MDR-TB among new cases was 9.2%, 13.8%, 16.9%, 23% 27.0%...
Background: Sputum decontamination with NALC-NaOH (N-acetyl-L-cysteine-sodium hydroxide) is known to better detect Mycobacterium tuberculosis (M.tb) by culture than that using NaOH, which widely used in Korean hospitals.In this report, sputum samples collected from pulmonary (TB) patients were treated either NaOH or NALC-NaOH, and we compared the results of smear positivity determine whether treatment method improves samples, especially for those are negative scanty.Methods: For each method,...
Background: Multidrug-resistant tuberculosis (MDR-TB) is an increasing public health problem and poses a serious threat to global TB control.Fluoroquinolone (FQ) aminoglycoside (AG) are essential anti-TB drugs for MDR-TB treatment.REBA MTB-FQ Ⓡ REBA MTB-KM (M&D, Wonju, Korea) were evaluated rapid detection of FQ kanamycin (KM) resistance in clinical isolates.Methods: M. (n=67) isolated cultured from the sputum samples patients extracting DNA bacilli.Mutations genes, gyrA rrs, that have been...
Background: First-line drugs, if sensitive, are the most potent drugs in treatment of multidrug-resistant tuberculosis (MDR-TB). This study examined frequency and risk factors associated with acquired drug resistance to first-line during a standardized using patients MDR-TB. Methods: included who were diagnosed MDR-TB at National Masan Tuberculosis Hospital between January 2004 May 2008, treated for whom preand post-treatment results susceptibility test available. Their medical records...
Abstract Background WGS has significant potential to help tackle the major public health problem of TB. The Republic Korea third highest rates TB all Organisation for Economic Cooperation and Development countries but there been very limited use in date. Objectives A retrospective comparison Mycobacterium tuberculosis (MTB) clinical isolates from 2015 2017 two centres using compare phenotypic drug susceptibility testing (pDST) predictions (WGS-DSP). Methods Fifty-seven MTB had DNA extracted...
Autophagy is the process of forming vesicle structure by response to nutritional deficiency or outside stress and then surrounding decomposing cell organelles make energy. Autophagy, which activated being given diverse stimuli including exercise, plays an important role in generating maintaining energy muscles as well skeletal muscle. However, there are very few studies on physiological mechanism explain effects such autophagy cardiac muscle both at home abroad. Thus, this experiment was...
Normal sectional anatomy of the calcaneus with multiplanar CT examination was studied in 5 volunteers as background for interpretation various abnormalities. Major 3 including plantar, coronal, sagittal and additional tuberosity planes are described. With calcaneus, 1. More detailed facets subtalar joint (anterior, middle, posterior facet) can be well visualized. 2. Its clinical applications tarsal trauma, coalition, infection, degenerative arthritis, club foot, pes planus tumor could...