A5076141180- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 Clinical Research Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- SARS-CoV-2 and COVID-19 Research
- Gallbladder and Bile Duct Disorders
- Nausea and vomiting management
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Gastric Cancer Management and Outcomes
- Phytoestrogen effects and research
- Helicobacter pylori-related gastroenterology studies
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Diabetes Treatment and Management
- Long-Term Effects of COVID-19
Okayama University Hospital
2022-2024
Okayama University
2022
Nara Medical University
2016-2022
Otsuka (Japan)
2022
Takeda (United States)
2021
Murata (United States)
2021
Weatherford College
2021
Nara Medical University Hospital
2021
Suzuki (Japan)
2021
Nara University
2021
Sodium‐glucose cotransporter 2 inhibitors (SGLT2‐Is) comprise a new class of antidiabetic agents that inhibit glucose reabsorption in the renal proximal tubules. Although recent report demonstrated potential ability SGLT2‐Is to attenuate cancer growth SGLT2‐expressing cells, little is known about effects on hepatocellular carcinoma (HCC). Here, we investigate anti‐cancer properties SGLT2‐I, canagliflozin, against human liver cells. SGTL2 mRNA and protein expression were detected Huh7 HepG2...
To determine the efficacy of rifaximin for hepatic encephalopathy (HE) with linkage gut microbiome in decompensated cirrhotic patients.Twenty patients (12 men and 8 women; median age, 66.8 years; range, 46-81 years) cirrhosis (Child-pugh score > 7) underwent cognitive neuropsychological testing, endotoxin analysis, fecal assessment at baseline after 4 wk treatment 400 mg thrice a day. HE was determined by serum ammonia level number connection test (NCT)-A. Changes whole blood activity (EA)...
Although some relationships between gut microbiota and liver diseases have been reported, it remains uncertain whether changes in owing to differences race, food living environment similar effects. Response ursodeoxycholic acid (UDCA) may predict the long-term prognosis of patients with primary biliary cholangitis (PBC); however, little is known about significance microbiome PBC. We elucidated among clinical profiles, biochemical response UDCA composition PBC.Fecal samples from 76 PBC...
Various symptoms persist even after the acute in about one third of patients with COVID-19. In February 2021, we established an outpatient clinic a university hospital for long COVID and started medical treatment sequelae that persisted month or more infection.To determine key factors affect onset clinical course sequelae, retrospective analysis was performed at Okayama University Hospital (Japan) between July 2021. We focused on changes numbers background during three-month period from...
Hypothyroidism might play a crucial role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The association subclinical hypothyroidism with NAFLD has been inconsistent. relationship thyroid function parameters and was determined.This cross-sectional study included 70 patients controls euthyroidism matched according to gender, age, body mass index (BMI). diagnosed via abdominal ultrasonography. between analyzed.The prevalence significantly higher than those euthyroidism....
Rifaximin is a poorly absorbable antibiotic against hepatic encephalopathy (HE). This observational study aimed to elucidate the effect of rifaximin on intestinal permeability and gut microbiota in patients with decompensated cirrhosis. Thirty cirrhosis were assessed by ammonia level, neuropsychological testing, endotoxin activity (EA), serum proinflammatory cytokines at baseline after four weeks treatment (1200 mg/day). Intestinal was indicated soluble CD163 (sCD163), mannose receptor...
The progression of nonalcoholic steatohepatitis (NASH) is complicated. multiple parallel-hits theory advocated, which includes adipocytokines, insulin resistance, endotoxins, and oxidative stress. Pathways involving the gut–liver axis also mediate NASH. Angiotensin-II receptor blockers (ARB) suppress hepatic fibrosis via activation stellate cells (HSCs). Rifaximin, a nonabsorbable antibacterial agent, used for treatment encephalopathy has been recently reported to improve intestinal...
Intestinal endotoxin is important for the progression of non-alcoholic steatohepatitis (NASH). Circulating levels are elevated in most animal models diet-induced fatty liver disease (NAFLD) and NASH. Furthermore, plasma significantly higher NAFLD patients, which associated with small intestinal bacterial overgrowth increased permeability. By improving gut microbiota environment restoring gut-barrier functions, probiotics effective NASH treatment models. It also widely known that hepatic...
Background/Aims Endoscopic resection (ER) for superficial non-ampullary duodenal epithelial tumors (SNADETs) is challenging. Conventional endoscopic mucosal (CEMR) also problematic due to the anatomical features of duodenum. We compared safety and efficacy underwater (UEMR) with those CEMR through a retrospective analysis. Methods Altogether, 44 consecutive patients 46 SNADETs underwent ER (18 cases 28 UEMR cases) between January 2016 October 2019. investigated proportions en bloc resection,...
Dipeptidyl peptidase-4 (DPP4) inhibitors (DPP4-I) are oral glucose-lowering drugs for type 2 diabetes mellitus. Previously, we reported that DPP4-I (sitagliptin) exerted suppressive effects on experimental liver fibrosis in rats. Blockade of the renin-angiotensin system by angiotensin-II 1 receptor blocker (losartan), commonly used management hypertension, has been shown to significantly alleviate hepatic fibrogenesis and carcinogenesis. We aimed elucidate possible mechanisms a sitagliptin +...
Various rodent models have been proposed for basic research; however, the pathogenesis of human nonalcoholic steatohepatitis (NASH) is difficult to closely mimic. Lipopolysaccharide (LPS) has reported play a pivotal role in fibrosis development during NASH progression via activation toll-like receptor 4 (TLR4) signaling. This study aimed clarify impact low-dose LPS challenge on pathological and establish novel murine model. C57BL/6J mice were fed choline-deficient l-amino-acid-defined (CDAA)...
Hepatocellular carcinoma (HCC) is the strongest independent predictor of mortality in non-alcoholic steatohepatitis (NASH)-related cirrhosis. The effects and mechanisms combination sodium-dependent glucose cotransporter inhibitor canagliflozin (CA) dipeptidyl peptidase-4 teneligliptin (TE) on non-diabetic NASH progression were examined. CA TE suppressed choline-deficient, L-amino acid-defined diet-induced hepatic fibrogenesis carcinogenesis. alone or with significantly decreased...
Hepatocellular carcinoma (HCC) is prone to recurrence following curative treatment. The purpose of the present study was identify predisposing factors HCC complete remission achieved by transarterial chemoembolization (TACE). A retrospective cohort 70 consecutive patients with who underwent TACE as initial treatment conducted. were divided into two groups according their 1‑year disease‑free survival (DFS) status; early group (ER group; n=32), recurring within 1 year TACE; and non‑early (NER...
It is unclear whether the link between non-alcoholic fatty liver disease (NAFLD) and chronic kidney (CKD) mediated by common risk factors. We aimed to elucidate association NAFLD CKD using propensity score (PS)-matched analysis. assessed 3725 Japanese individuals, excluding those with hepatitis B or C infection men women who consumed >30 >20 g/day of alcohol, respectively. Of these, we enrolled 1097 subjects diagnosed ultrasonography PS-matched without NAFLD. The prevalence was higher in...
AIMTo evaluate the diagnostic performance of angiotensinconverting enzyme (ACE) on significant liver fibrosis in patients with chronic hepatitis B (CHB).
We aimed to prospectively identify the risk factors of sarcopenia in patients with cirrhosis.Patients (n = 193) included a discovery cohort (January 2011 and December 2014) were categorized into alcoholic (A1; n 55) non-alcoholic cirrhosis (NA; 138) groups, those 235) validation 2015 2019) 92), steatohepatitis-related 27), hepatitis C virus-related groups 116). Skeletal muscle mass index (SMI) was determined using computed tomography (SMI-CT) bioelectrical impedance analysis (SMI-BIA)....
Even though the Barcelona Clinic Liver Cancer (BCLC) staging system is widely accepted, controversies on management of hepatocellular carcinoma (HCC) still exist. We evaluated efficacy an approach with repeated hepatic arterial infusion chemotherapy (HAIC) given at eight-week intervals for treatment advanced HCC.Of 66 compensated cirrhotic patients HCC refractory to transcatheter chemo-embolization (TACE) enrolled in our study, 21 were treated by bi-monthly (B-HAIC) and rest sorafenib. The...
We previously reported the comparable efficacy of bi-monthly hepatic arterial infusion chemotherapy (B-HAIC) to that sorafenib for treatment advanced hepatocellular carcinoma (aHCC) in patients with compensated cirrhosis. In this study, we demonstrate B-HAIC decompensated cirrhosis.Forty-five aHCC refractory transcatheter chemo-embolization (TACE) were treated and divided into two groups according functional reserve (Child-Pugh grade). Overall survival period, response, adverse events each...
Abstract The presence of bridging fibrosis predicts survival primary biliary cholangitis (PBC). This study aimed to compare serum parameters for the estimation liver and prediction clinical outcomes in PBC. Out 392 patients with PBC, 102 who underwent biopsy whom indices, platelet count, hyaluronic acid, type IV collagen 7 second domain, procollagen III amino-terminal peptide, tissue inhibitor metalloproteinases 1, Mac-2 binding protein glycosylation isomer, N-terminal propeptide levels;...
Amid the Coronavirus Disease 2019 pandemic, we aimed to demonstrate accuracy of fingertip whole blood sampling test (FWT) in measuring antibody titer and uncovering its dynamics shortly after booster vaccination. Mokobio SARS-CoV-2 IgM & IgG Quantum Dot immunoassay (Mokobio Biotechnology R&D Center Inc., MD, USA) was used as a point-of-care FWT 226 health care workers (HCWs) who had received two doses BNT162b2 mRNA vaccine (Pfizer-BioNTech) at least 8 months prior. Each participant tested...
The farnesoid X receptor (FXR) agonist, a bile acid‐activated nuclear receptor, has been shown to improve the histologic features of nonalcoholic steatohepatitis (NASH); however, satisfactory effect on hepatic fibrosis not achieved. We aimed investigate combined FXR agonist and angiotensin II type 1 blocker fibrogenesis in rat models NASH. For 8 weeks, two NASH were developed. Otsuka Long‐Evans Tokushima Fatty (OLETF) rats administered intraperitoneal injections mL/kg pig serum (PS) twice...
Aim: The aim of the present study is to investigate effect long-term zinc supplementation, which important for activation various enzymes that contribute antioxidant and antifibrotic activities, on improvement serum fibrotic markers in patients with autoimmune hepatitis (AIH). Methods: A total 38 AIH under regular treatment at our hospital who provided their consent being treated polaprezinc (75 mg twice daily) were included classified into 2 groups: elevation (n = 27) without 11). Serum...