A5018361675- Viral Infections and Outbreaks Research
- Metabolomics and Mass Spectrometry Studies
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Liver Diseases and Immunity
- Noise Effects and Management
- Air Quality and Health Impacts
- Adipose Tissue and Metabolism
- Biosimilars and Bioanalytical Methods
- Advanced Proteomics Techniques and Applications
- Mosquito-borne diseases and control
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Nitric Oxide and Endothelin Effects
- Herpesvirus Infections and Treatments
- Heavy Metal Exposure and Toxicity
- Mitochondrial Function and Pathology
- Advanced Nanomaterials in Catalysis
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Pediatric Hepatobiliary Diseases and Treatments
- Diet, Metabolism, and Disease
- Primate Behavior and Ecology
UCB Pharma (Belgium)
2024
Emory University
2015-2019
Florida Atlantic University
2010
Inhibition of the ileal bile acid transporter treats multiple features nonalcoholic steatohepatitis in high-fat diet–fed mice.
Chronic malaria is a major public health problem and significant challenge for disease eradication efforts. Despite its importance, the biological factors underpinning chronic are not fully understood. Recent studies have shown that host metabolic state can influence pathogenesis transmission, but role in chronicity known. Here, with goal of identifying distinct modifications metabolite profiles acute versus malaria, metabolomics was performed on plasma from Plasmodium-infected humans...
Inhalation of cadmium (Cd) is associated with lung diseases, but less known concerning pulmonary effects Cd found in the diet. has a decades-long half-life humans and significant bioaccumulation occurs chronic dietary intake. We exposed mice to low-dose CdCl2 (10 mg/L drinking water) for 20 weeks, which increased level similar that nonoccupationally adult humans. Cd-treated had airway hyperresponsiveness methacholine challenge, gene expression array showed altered abundance 443 mRNA...
Figure 1 (A) The trimeric Ebola Virus glycoprotein (silver) interacts with the light (orange) and heavy (green) chains of human antibody KZ52.Purple boxes indicate sites interactions, all which are identical.(B) EBOV GP epitope (purple) loops at slits.(C) Salt bridges stabilize epitope-antibody binding.Salt-bridge measurements from top to bottom 3.41 Å, 2.77 3.24 3.35 2.90 Å.
Ligand-binding assays (LBAs) rely on the reversible, noncovalent binding between analyte of interest and assay reagents, understanding their dynamic equilibrium is key to building robust LBA methods. Although interplay free bound fractions can be calculated using mathematical models, these are not routinely applied. This approach costly in terms both development time result an under-exploration possible parameter combinations. Therefore, we have created a user-friendly simulation tool...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic in Western world.The mechanisms underlying NAFLD development and progression are not fully elucidated, safe effective therapies needed.Bile acids (BA) their receptors have important roles regulating whole body metabolism, including multiple hepatic targets coordinating lipid handling.We hypothesized that interruption of enterohepatic BA circulation via a non-absorbable Apical Sodium-dependent Transporter (ASBT) inhibitor...