A5050265996- Malaria Research and Control
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Parasites and Host Interactions
- Complement system in diseases
- Computational Drug Discovery Methods
- Diverse Scientific Research Studies
- Migration, Health and Trauma
- Natural Compounds in Disease Treatment
- Hematological disorders and diagnostics
- Autophagy in Disease and Therapy
- vaccines and immunoinformatics approaches
- Global Maternal and Child Health
Mahidol University
1998-2024
Microscopy of Giemsa-stained thick and thin films by a skilled microscopist has remained the standard laboratory method for diagnosis malaria. However, malaria with this is problematic since interpretation results requires considerable expertise, particularly at low parasite levels. We compared efficacy "field" "expert laboratory" microscopy active surveillance Plasmodium falciparum P. vivax in western Thailand. Field consisted an approximately five-minute read (50-100 fields) film x700...
Chronic malaria is a major public health problem and significant challenge for disease eradication efforts. Despite its importance, the biological factors underpinning chronic are not fully understood. Recent studies have shown that host metabolic state can influence pathogenesis transmission, but role in chronicity known. Here, with goal of identifying distinct modifications metabolite profiles acute versus malaria, metabolomics was performed on plasma from Plasmodium-infected humans...
The study of the biology, transmission and pathogenesis Plasmodium vivax is hindered due to lack a robustly propagating, continuous culture this parasite. current system for P. parasites still suffered from consistency difficulties in long-term maintenance providing sufficient biological materials studying parasite biology. Therefore, further improvement conditions needed. Clinical samples were collected patients diagnosed with western Thailand. Leukocyte-depleted infected blood cultured...
In low malaria transmission areas, many people acquire multiple infections within a single season. This study aimed to describe the pattern and epidemiological profile of recurrence in hypoendemic area western Thailand identify factors associated with having episodes.An open cohort 7000 residents seven clusters along Thai-Myanmar border was followed during 6.5-year period (2011-mid 2017). Symptomatic asymptomatic were detected by passive case detection (PCD), weekly household visit, mass...
Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs vaccines. However, unlike Plasmodium falciparum, well-characterized P. vivax parasites that are safe suitable for use modern CHMI models limited. Here, 2 healthy malaria-naive United Kingdom adults with universal donor blood group were safely infected clone from Thailand by mosquito-bite CHMI. Parasitemia...
Although human infections of Plasmodium knowlesi have been found throughout Southeast Asia, most cases originated from Malaysian Borneo. In Thailand, P. malaria was considered extremely rare. However, during October 2017–September 2018, there a surge in the number reported cases. Here, series six this period Songkhla and Narathiwat provinces southern Thailand are presented. All were confirmed by polymerase chain reaction. The unprecedented case affected area is warning sign an increasing...
Malaria cross-sectional surveys are rarely conducted in very low transmission settings. This study aimed to determine the prevalence and risk factors of Plasmodium infection a near-elimination setting southern Thailand.Two were areas active Surat Thani province Thailand January May 2019. PCR was used detect infection.The blood 0.45% 0.61% 2019, respectively. The major parasite species falciparum vivax May. Unexpectedly, knowlesi infections also detected. Most infections, including those...
Plasmodium vivax preferentially infects Duffy-positive reticulocytes and infections typically have few parasite-infected cells in the peripheral circulation. These features complicate detection quantification by flow cytometry (FC) using standard nucleic acid-based staining methods. A simple antibody-based FC method was developed for rapid parasite along with simultaneous of other erythrocyte markers. Clinical samples were collected from patients diagnosed P. at a district Malaria Clinic...
Abstract Background Typically mobile and vulnerable, migrants face significant barriers to access routine malaria prevention, diagnostics treatment, which leads unchecked transmission, particularly in border regions with a high population displacement. This study aimed investigate the demographic socioeconomic obstacles services among Myanmar residing Thailand–Myanmar areas. Methods A cross-sectional was conducted early 2024 across three districts near border. Quantitative data were...
Abstract Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs vaccines. However, unlike Plasmodium falciparum , well-characterized P. vivax parasites that are safe suitable for use modern CHMI models limited. Here, two healthy malaria-naïve UK adults with universal donor blood group were safely infected clone from Thailand by mosquito-bite CHMI. Parasitemia...