A5075760256- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Muscle metabolism and nutrition
- Diabetes Treatment and Management
- Diabetes Management and Research
- Physical Activity and Health
- Diabetes and associated disorders
- Chronic Disease Management Strategies
- Nutritional Studies and Diet
- Cardiovascular and exercise physiology
- COVID-19 and healthcare impacts
- Exercise and Physiological Responses
- Obesity, Physical Activity, Diet
- Long-Term Effects of COVID-19
- Cardiovascular Health and Disease Prevention
- Sports Performance and Training
- Adipose Tissue and Metabolism
- Frailty in Older Adults
- Aging and Gerontology Research
- Cardiovascular Function and Risk Factors
- Geriatric Care and Nursing Homes
- Curcumin's Biomedical Applications
- Vitamin C and Antioxidants Research
- Genetics, Aging, and Longevity in Model Organisms
- Diabetes Management and Education
Manchester Metropolitan University
2020-2025
Newcastle University
2019-2024
Newcastle upon Tyne Hospital
2020-2023
University of Liverpool
2017-2021
Aintree University Hospitals NHS Foundation Trust
2020-2021
Liverpool John Moores University
2015-2020
Aintree University Hospital
2017-2019
Low physical activity levels and sedentary behaviour are associated with obesity, insulin resistance type 2 diabetes. We investigated the effects of a short-term reduction in increased on metabolic profiles body composition, comparing individuals first-degree relatives diabetes (FDR+ve) vs those without (FDR−ve). Forty-five habitually active participants (16 FDR+ve [10 female, 6 male] 29 FDR−ve [18 11 male]; age 36 ± 14 years) were assessed at baseline, after days step resuming normal...
ABSTRACT Introduction/Purpose To investigate whether (a) lower levels of daily physical activity (PA) and greater sedentary time accounted for contrasting metabolic phenotypes (higher liver fat/presence syndrome [METS+] vs fat/absence [METS−]) in individuals similar body mass index (b) the association on health fat. Methods Ninety-eight habitually active participants (53 female, 45 male; age, 39 ± 13 yr; 26.9 5.1 kg·m −2 ), underwent assessments PA (SenseWear armband; wear ~98%),...
Research is ongoing to increase our understanding of how much a previous diagnosis type 2 diabetes mellitus (T2DM) affects someone's risk becoming seriously unwell following COVID-19 infection. In this study we set out determine the relative likelihood death infection in people with T2DM when compared those without T2DM. This was conducted as an urban population and based UK.Analysis electronic health record data performed relating living Greater Manchester conurbation (population 2.82...
Since early 2020 the whole world has been challenged by SARS-CoV-2 virus and associated global pandemic (Covid-19). People with diabetes are particularly at high risk of becoming seriously unwell after contracting this virus.This population-based study included people living in Greater Manchester conurbation who had a recorded diagnosis type 1 mellitus (T1DM) or 2 (T2DM) subsequent Covid-19 infection. Each individual T1DM (n = 862) T2DM 13,225) was matched three Covid-19-infected...
Introduction During acute feeding trials, consuming a large dose of whey protein (WP) before meals improves postprandial glucose regulation in people with type 2 diabetes. It is unclear if the reported benefits premeal WP supplementation are translatable to everyday care or associated clinically meaningful, real-world glycemic outcomes. This study examined application novel, shot containing low on parameters free-living control Research design and methods In randomized, placebo-controlled,...
Treatments that reduce postprandial glycemia (PPG) independent of stimulating insulin secretion are appealing for the management type 2 diabetes (T2D). Consuming pre-meal whey protein (WP) reduces PPG by delaying gastric emptying and increasing plasma concentrations. However, its effects on β-cell function kinetics remains unclear.
Data suggest that metabolic health status, incorporating components of syndrome (MetS), predicts cardiovascular disease (CVD) risk better than BMI. This study explored the association MetS and obesity with endothelial function, a prognostic factor for incident CVD.Forty-four participants were phenotyped according to BMI as non-obese vs obese (<30 or >30 kg/m2) International Diabetes Federation criteria MetS: ≤2 (MetS-) ≥3 (MetS+); (1.)non-obese MetS- (2.) MetS+ (3.) (4.) MetS+. Flow-mediated...
We investigated whether diurnal differences in muscle force output are associated with the post-translational state of proteins. Ten physically active men (mean ± SD; age 26.7 3.7 y) performed experimental sessions morning (08:00 h) and evening (17:00 h), which were counterbalanced order administration separated by at least 72 h. Knee extensor maximal voluntary isometric contraction (MVIC) peak rate development (RFD) measured, samples vastus lateralis collected immediately after exercise....
This study examined the effects of a short-term reduction in physical activity, and subsequent resumption, on metabolic profiles, body composition cardiovascular (endothelial) function.Twenty-eight habitually active (≥10,000 steps/day) participants (18 female, 10 male; age 32 ± 11 years; BMI 24.3 2.5 kg/m2) were assessed at baseline, following 14 days step-reduction after resuming habitual activity.Physical activity was monitored throughout (SenseWear Armband). Endothelial function (flow...
Abstract Aims/hypothesis The temporal suppression of insulin clearance after glucose ingestion is a key determinant tolerance for people without type 2 diabetes. Whether similar adaptations are observed the mixed-macronutrient meal unclear. Methods In secondary analysis data derived from two randomised, controlled trials, we studied responses standardised breakfast consisting cereal and milk in lean normoglycaemic individuals ( n =12; Lean-NGT), with central obesity =11; Obese-NGT) diabetes...
Divergent selection has created rat phenotypes of high‐ and low‐capacity runners (HCR LCR, respectively) that have differences in aerobic capacity correlated traits such as adiposity. We analyzed visceral adipose tissue HCR LCR using label‐free high‐definition MS (elevated energy) profiling. The running was ninefold greater than LCR. Proteome profiling encompassed 448 proteins detected 30 significant ( p <0.05; false discovery rate <10%, calculated q ‐values) differences. Approximately...
Elevated postprandial glycaemia [PPG] increases the risk of cardiometabolic complications in insulin-resistant, centrally obese individuals. Therefore, strategies that improve PPG are importance for this population. Consuming large doses whey protein [WP] before meals reduces by delaying gastric emptying and stimulating secretion incretin peptides, glucose-dependent insulinotropic polypeptide [GIP] glucagon-like peptide 1 [GLP-1]. It is unclear if these effects observed after smaller amounts...
Since early 2020 the whole world has been challenged by SARS-CoV-2 virus (COVID-19), its successive variants and associated pandemic caused. We have previously shown that for people living with type 2 diabetes (T2DM), risk of being admitted to hospital or dying following a COVID-19 infection progressively decreased through first months 2021. In this subsequent analysis we examined how UK vaccination programme impacted differentially on outcomes in T1DM T2DM compared appropriate controls....
Abstract Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus (coronavirus disease 2019 [COVID-19]) pandemic revealed the vulnerability of specific population groups in relation to susceptibility deterioration their health, including hospital admission and mortality. There is less data on outcomes for people with type 1 diabetes (T1D) following SARS-CoV-2 infection than those (T2D). In this study we set out determine relative likelihood T1D when compared...
Since early 2020, the SARS-CoV-2 virus (COVID-19) has challenged world and perturbed our healthcare systems [1]. People with type 2 diabetes (T2D) are known to be at a higher risk of becoming unwell following COVID-19 infection when compared people who do not have T2DM [2]. Access longitudinal general practice electronic health records for allowed greater resolution outcomes over time those contracted COVID-19. From start pandemic in monthly incidence populations varied both between...
Access to longitudinal digital health records allows analysis of trajectory for individuals with many long-term conditions and is direct relevance in understanding the way which SARS-CoV-2 virus (COVID-19) has affected lives millions people across world diabetes, as it also challenged our global healthcare systems [1]. People diabetes are known be at higher risk becoming unwell following COVID-19 infection when compared nondiabetes [2]. Since start pandemic early 2020, monthly incidence...