A5103123966- Alzheimer's disease research and treatments
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neural Engineering
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Neurological Disorders and Treatments
- Planarian Biology and Electrostimulation
- Cholinesterase and Neurodegenerative Diseases
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Spatial Neglect and Hemispheric Dysfunction
- Neurological Disease Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Ear and Head Tumors
- COVID-19 and healthcare impacts
- Brain Metastases and Treatment
- Plant and animal studies
- Vascular Malformations and Hemangiomas
- Single-cell and spatial transcriptomics
- Nerve injury and regeneration
- Diet and metabolism studies
- Plant and Biological Electrophysiology Studies
- Machine Learning in Healthcare
Salford Royal NHS Foundation Trust
2023
Albert Einstein College of Medicine
2020-2023
Montefiore Medical Center
2020-2023
City University of New York
2017-2022
The Graduate Center, CUNY
2017-2019
The University of Texas Southwestern Medical Center
2018
CUNY School of Law
2017
Objective To examine associations of molecular markers brain insulin signaling with Alzheimer disease (AD) and cognition among older persons or without diabetes. Methods This clinical–pathologic study was derived from a community‐based cohort study, the Religious Orders Study. We studied 150 individuals (mean age at death =87 years, 48% women): 75 diabetes (matched by sex on education). Using enzyme‐linked immunosorbent assay, immunohistochemistry, ex vivo stimulation tissue insulin, we...
We have previously shown that male mice living in groups of 12 males establish and maintain stable linear social hierarchies with each individual having a defined rank. However, it is not clear which cues use to signal recognize their relative status within hierarchy. In this study, we investigate how both pairs affects the levels major urinary proteins (MUPs) specifically MUP20 urine. housed adult outbred CD1 complex environment for three weeks collected urine samples from all individuals...
Background Hearing loss is a prevalent late effect among cancer survivors. Despite the significant social costs, there noted delay in seeking care and to authors' knowledge are limited data regarding lived experiences of survivors with hearing loss. The objective current study was explore experience childhood young adult cancers guide survivorship care. Methods A total 24 participated semistructured telephone interviews. Inclusion criteria consisted clinical visit at Adult Long‐Term...
Abstract Background The apolipoprotein E ε4 ( APO E4) genotype is a prominent late-onset Alzheimer’s disease (AD) risk factor. ApoE4 disrupts memory function in rodents and may contribute to both plaque tangle formation. Methods Coimmunoprecipitation Western blot detection were used determine: 1) the effects of select fragments from apoE low-density lipoprotein (LDL) binding domain recombinant subtypes on amyloid beta (Aβ) 42 -α7 nicotinic acetylcholine receptor (α7nAChR) interaction tau...
The ototoxic effects of radiotherapy have been poorly characterized. We examined adult survivors childhood cancer who were treated with radiotherapy, which included the head, before age 22 years and between 1952 2016. Those received platinum chemotherapy excluded. Demographic, diagnosis, treatment outcomes captured. Audiograms graded using Chang International Society Paediatric Oncology ototoxicity (SIOP) scales. Among 276 patients a history radiation to sites that brain, orbit, nasopharynx,...
Abstract Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus (coronavirus disease 2019 [COVID-19]) pandemic revealed the vulnerability of specific population groups in relation to susceptibility deterioration their health, including hospital admission and mortality. There is less data on outcomes for people with type 1 diabetes (T1D) following SARS-CoV-2 infection than those (T2D). In this study we set out determine relative likelihood T1D when compared...
Leptin can impair signaling of the insulin receptor (IR) by promoting suppressor cytokine 1 and 3 (SOCS1 SOCS3) binding with IR. We studied if this is a cause resistance in hippocampal formation (HF) mild cognitively impaired (MCI) Alzheimer's disease dementia (ADd) cases represented ADRC brain banks Rush University Pennsylvania. Fresh frozen HF tissue was obtained from age- -sex matched Caucasians no history diabetes low postmortem intervals (m ± SD = 6.75 2.2 h). They were non-cognitively...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)