A5049842363- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Muscle metabolism and nutrition
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Diabetes Management and Research
- Health and Lifestyle Studies
- Dementia and Cognitive Impairment Research
- Peroxisome Proliferator-Activated Receptors
- Diabetes Treatment and Management
- Diet and metabolism studies
- Identification and Quantification in Food
- Cancer, Hypoxia, and Metabolism
- Neurological Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Obesity, Physical Activity, Diet
- Cassava research and cyanide
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sleep and Wakefulness Research
- Physical Activity and Health
Université Ibn-Tofail
2022-2025
University of Geneva
2024
Johns Hopkins Medicine
2020-2023
Johns Hopkins University
2019-2023
Centre Hospitalier de l’Université de Montréal
2013-2019
Université de Montréal
2013-2015
Glioblastoma multiforme (GBM) is the most common and lethal primary malignant brain tumor in adults. Despite multimodal standard treatments for GBM, median survival still about one year. Analysis of tissues from GBM patients shows that lipid droplets are highly enriched while undetectable normal tissues, yet identity functions species not well understood. The aims present work to determine how utilizes fatty acids, assess their roles proliferation. Treatment U138 cells with a monounsaturated...
Objective To examine associations of molecular markers brain insulin signaling with Alzheimer disease (AD) and cognition among older persons or without diabetes. Methods This clinical–pathologic study was derived from a community‐based cohort study, the Religious Orders Study. We studied 150 individuals (mean age at death =87 years, 48% women): 75 diabetes (matched by sex on education). Using enzyme‐linked immunosorbent assay, immunohistochemistry, ex vivo stimulation tissue insulin, we...
Glial cells have emerged as key players in the central control of energy balance and etiology obesity. Astrocytes play a role neural communication via release gliotransmitters. Acyl-CoA–binding protein–derived (ACBP-derived) endozepines are secreted peptides that modulate GABAA receptor. In hypothalamus, ACBP is enriched arcuate nucleus (ARC) astrocytes, ependymocytes, tanycytes. Central administration endozepine octadecaneuropeptide (ODN) reduces feeding improves glucose tolerance, yet...
Hypothalamic controls of energy balance rely on the detection circulating nutrients such as glucose and long-chain fatty acids (LCFA) by mediobasal hypothalamus (MBH). LCFA metabolism in MBH plays a key role control food intake homeostasis, yet it is not known if regulates oxidation esterification and, so, which hypothalamic cell type(s) intracellular signaling mechanisms are involved. The aim this study was to determine impact metabolism, assess AMP-activated Kinase (AMPK), establish...
Acyl-CoA-binding protein (ACBP) is a ubiquitously expressed that binds intracellular acyl-CoA esters. Several studies have suggested ACBP acts as an pool former and regulates long-chain fatty acids (LCFA) metabolism in peripheral tissues. In the brain, known Diazepam-Binding Inhibitor, secreted peptide acting allosteric modulator of GABAA receptor. However, its role central LCFA remains unknown. present study, we investigated cellular expression, regulation metabolism, FA profile,...
Previous studies have shown that variations in the CD36 gene may affect phenotypes associated with fat metabolism as protein facilitates transport of fatty acids to mitochondria for oxidation. However, no previous study has tested whether are sports performance. We investigated genotypic and allelic distribution single-nucleotide polymorphism (SNP) rs1761667 elite Moroccan athletes (cyclists hockey players) comparison healthy non-athletes same ethnic origin. Forty-three male (nineteen...
Background The dietary quality of young adults often worsens during the transition to adulthood. University students, especially considering documented gender differences in eating habits, are prime targets for promoting healthy lifestyles prevent noncommunicable diseases. Objective This study investigates prevalence overweight among students and analyzes disparities physical activity, practices, use complementary medicine across genders, while also exploring factors influencing overweight....
all around the world, type 2 diabetes is considered a metabolic disease that generates complications can be very serious, even fatal, over time, especially if not properly managed. Clinical and biological parameters in blood glucose levels will assessed this study (N=300 patients). We assess prevalence of caused by including diabetic retinopathy, nephropathy, neuropathy, cardiovascular diseases. Type an incurred disease, but it Self-therapeutic education therefore imperative highly...
Abstract Hyperandrogenism and polycystic ovarian syndrome result from the imbalance or increase of androgen levels in females. Androgen receptor (AR) mediates effects androgens, this study examines whether neuronal AR plays a role reproduction under normal increased conditions female mice. The neuron-specific knockout (KO) mouse (SynARKO) was generated (synapsin promoter driven Cre) male (Ar fl/y). Puberty onset reproductive hormones such as LH, FSH, testosterone, estradiol were comparable...
Introduction: Salmonellosis is a foodborne bacterial disease responsible for food epidemics around the world. The objective of this study to determine prevalence and diversity Salmonella serotypes in several products isolated at Casablanca Regional Analysis Research Laboratory test their resistance different antimicrobials. Methodology: isolation identification were performed according Moroccan standard 08.0.116. All isolates serotyped then tested antibiotic using disk diffusion method....