Abstract Human perinatal tissue is an abundant source of mesenchymal stromal cells(MSCs) and lacks the ethical concerns. Perinatal MSCs can be obtained from various tissues as like amnion, chorion, umbilical cord. Still, little known distinct nature each MSC type. In this study, we successfully isolated cultured amnion(AMSCs), chorion(CMSCs), cord(UC-MSCs). Proliferation potential was different among them, that AMSCs revealed lowest proliferation rate due to increased Annexin V...

Abstract Background The purpose of the study was to evaluate effects maternal pre-pregnancy body mass index (BMI) and gestational weight gain on perinatal outcomes in a population Korean women. Methods We retrospectively reviewed medical records 2,454 women who had received antenatal care at Seoul St. Mary's Hospital from January 2007 December 2009. used World Health Organization definitions for Asian populations underweight (BMI < 18.5), normal equal or higher 18.5 23), overweight 23...

This study was undertaken to investigate the pregnancy outcomes in patients with systemic lupus erythematosus (SLE) and appropriate timing of pregnancy.We performed a retrospective evaluation 183 pregnancies SLE at Catholic University Medical Center during 13-year period from 1998 2010.Pregnancy were compared according characteristics.The predictive value different cut-off points stable before conception on adverse calculated by ROC (Receiver operating characteristics) curve analysis.In...

Recent evidence has revealed associations between endocrine-disrupting chemicals (EDCs) and placental insufficiency due to altered growth, syncytialization, trophoblast invasion. However, no epidemiologic study reported exposure EDCs asymmetric fetal growth restriction (FGR) caused by placenta insufficiency. The aim of this was evaluate the association EDC FGR. This a prospective cohort including women admitted for delivery Maternal Fetal Center at Seoul St. Mary’s Hospital October 2021...

Purpose:The purpose of this retrospective cohort study was to elucidate whether the location placenta below uterine incision in cesarean section is important development maternal complications previa patients.Methods: The conducted on 409 patients 414 parturition at 3 hospitals affiliation with Catholic Medical Center, Seoul, Korea from May 1999 December 2009.The subjects were divided two groups: group whose located anterior portion uterus (anterior group) and posterior (posterior group).And...

This study developed a machine learning algorithm to predict gestational diabetes mellitus (GDM) using retrospective data from 34,387 pregnancies in multi-centers of South Korea. Variables were collected at baseline, E0 (until 10 weeks' gestation), E1 (11-13 gestation) and M1 (14-24 gestation). The set was randomly divided into training test sets (7:3 ratio) compare the performances light gradient boosting (LGBM) extreme (XGBoost) algorithms, with full variables (original). A prediction...

Abstract Background Although pregnancy-associated heart failure with preserved ejection fraction (HFpEF) is increasing and contributing to maternal morbidity, little known about its impact on pregnancy. We examined the risk factors for adverse pregnancy outcomes of HFpEF in pregnant women. Methods conducted a cross-sectional analysis pregnancy-related hospitalizations from 2009 2020 using perinatal database seven multicenters. Cases were identified International Classification Diseases...

This study was conducted to analyze recent trends of multiple birth rates (MBR) and fetal/neonatal/infant mortalities according the number gestations in Korea.Data from 2009 2015 live births, infant deaths stillbirths were obtained Korean Vital Statistics. Neonatal mortality rate (NMR), (IMR), fetal (FMR) singleton, twin triplet pregnancies analyzed gestational period (GP; ≤ 23, 24-27, 28-31, 32-36 weeks).From 2015, increased 34.5% 154.3%, respectively. In NMR FMR have been decreased...

The identification of antenatal depression is critical but poorly conducted.The aim this study was to construct a simplified survey scale and verify its efficacy as pre-screening for depression.A total 494 pregnant women in the third trimester gestation who had received care at Seoul St. Mary's Hospital from July 2009 June 2010 were included.The Edinburgh Postnatal Depression Scale (EPDS) questionnaire completed by them.The subjects randomly divided into two groups: 250 training set 244...

The World Health Organization (WHO) international body mass index (BMI) cut-off points defining pre-pregnancy BMI categories in the Institute of Medicine (IOM) guidelines are not directly applicable to Asians. We aimed define optimal gestational weight gain (GWG) for Korean population based on Asia-specific categories.Data from 2702 live singleton deliveries three tertiary centers between 2010 and 2011 were analyzed retrospectively. A multivariable logistic regression analysis was conducted...

Mesenchymal stem cells (MSCs) are an attractive tool to treat graft-versus-host disease because of their unique immunoregulatory properties. Although human bone marrow-derived MSCs (BM-MSCs) were the most widely used in cell therapy until recently, derived from umbilical cords (UC-MSCs) have gained popularity as material for ethical and noninvasive collection.To investigate difference mechanisms immunosuppressive effects UC-MSCs BM-MSCs.To analyze soluble factors expressed by MSCs, such...

In an 8-year period at two medical center, 138 patients underwent uterine artery embolization, and 11 of them were diagnosed with necrosis. Among them, three successfully conceived. However, one developed arteriovenous malformation after artificial abortion, another experienced complications, including placenta previa accreta spectrum, which resulted in early preterm delivery recurrent postpartum hemorrhage, necessitating subtotal hysterectomy. Therefore, it is crucial to prepare for...

This study focused on the characterization of mesenchymal stromal cells (MSCs) from chorion human full term placenta 15 donors. Chorionic MSCs revealed homologous fibroblast-like morphology and expressed CD73, CD29, CD105, CD90. The hematopoietic stem cell markers including HLA DR, CD11b, CD34, CD79a, CD45 were not expressed. growth kinetics their serial passage was steady at later passages (passage 10). multilineage capability chorionic demonstrated by successful adipogenic, osteogenic...

Our previous studies have shown that oncostatin M (OSM) promotes trophoblast invasion activity through increased enzyme of matrix metalloproteinase (MMP)-2 and -9. We further investigated OSM-induced intracellular signaling mechanisms associated with these events in the immortalized human cell line HTR8/SVneo. effects OSM on RNA protein expression MMP-2 -9 first-trimester extravillous (HTR8/SVneo) via Western blot. The selective signal transducer activator transcription (STAT)3 inhibitor,...

Background:We evaluated the effects of fibronectin, collagen, cadherin, and laminin based extracellular matrix (ECM) protein mimetics coated with mussel derived adhesive (MAP) on adhesion proliferation chorionic mesenchymal stem cells (cMSCs).Methods: Human placental tissues from term third-trimester pregnancies (n=3) were used.The cMSCs cultured rationally designed ECM MAP plastic surfaces addition reduced fetal bovine serum (0.5%, 1% FBS).Adhesion capabilities monitored by a real time cell...

Objectives: This study aims to investigate the independent influence of maternal age on risk emergency cesarean section (CS) due nonreassuring fetal heart rate or arrest disorder.Methods: was a cross-sectional women with nulliparous pregnancies, who are attempting vaginal delivery at term and have cephalic presentation without indication elective CS onset labor. The primary outcome CS. Independent factors were elucidated using multivariate logistic regression analysis.Results: Of 3513 women,...

During the first trimester of pregnancy, trophoblastic E-cadherin expression is down-regulated, thereby allowing extravillous trophoblasts (EVTs) to acquire potential for migration and invasiveness. The aim present study was investigate role OSM on proliferation EVT cell line HTR8/SVneo with regard its effects STAT3 activation.We investigated RNA protein by real time RT-PCR analyses, western blotting, indirect immunofluorescence staining in cells, as well proliferation. selective signal...

The 2009 Institute of Medicine (IOM) guidelines for gestational weight gain (GWG) are intended use among women in the United States. Little data available on whether IOM recommendations can be applied to Asian women. This study aimed evaluate related adverse pregnancy outcomes Korean pregnant women.A retrospective cohort was conducted all singleton-pregnant at a university hospital Korea. After classifying enrolled into four pre-pregnancy body mass index (BMI) categories, risk were analyzed...

Marker chromosomes are small supernumerary that cannot be unambiguously identified by chromosome banding techniques alone. However, the precise characterization of marker is important for prenatal diagnosis and proper genetic counseling. In this study, we evaluated chromosomal origin using a combination cytogenetics molecular cytogenetic including diverse fluorescence in situ hybridization (FISH) assays array comparative genomic (array CGH).In series 2871 patients whom analysis was...

The purpose of this study was to evaluate the efficacy and adverse effects uterine artery embolization (UAE) treat postpartum hemorrhage (PPH) determine factors associated with clinical outcomes.This included 117 patients who underwent UAE for PPH between January 2010 November 2018. Their medical records were retrospectively reviewed assess mode delivery, causes bleeding, detailed laboratory results, outcomes, time from delivery UAE, embolizing material used.The success rate 99.1%. Late...

Our objective was to evaluate risks of adverse obstetric outcomes in pregnancies with myoma(s) or following myomectomy.We analyzed the national health insurance database, which covers almost entire Korean population, between 2004 and 2015. The pregnancy myomectomy, compared those women without a diagnosed myoma, were multivariate logistic regression analysis.During study period, 38,402 myoma(s), 9890 history 740,675 myoma gave birth. Women myomectomy had significantly higher cesarean section...

We intended to identify the risk factors of intraoperative hemorrhage on occasions a combined operation myomectomy with cesarean section for patients uterine leiomyoma. A retrospective cohort study was done all who underwent intramural leiomyoma at single university hospital. Cases identified subserosal leiomyoma, placental disorder, and comorbid conditions related coagulopathy were excluded. All included cases classified into non-hemorrhage group. Obstetric demographic parameters compared...