A5020033645- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- T-cell and Retrovirus Studies
- Cell Adhesion Molecules Research
- Dermatological and COVID-19 studies
- COVID-19 Clinical Research Studies
- Hematological disorders and diagnostics
- SARS-CoV-2 and COVID-19 Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Psoriasis: Treatment and Pathogenesis
- COVID-19 Impact on Reproduction
- Science and Education Research
- Physiological and biochemical adaptations
- Cutaneous lymphoproliferative disorders research
- Immune Cell Function and Interaction
- Aquaculture Nutrition and Growth
- Blood disorders and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Research on Leishmaniasis Studies
- Vector-Borne Animal Diseases
- Pancreatic and Hepatic Oncology Research
Hospital Prof. Dr. Fernando Fonseca
2025
Hospital do Servidor Público Municipal
2020-2024
Hospital do Servidor Público Estadual
2005-2024
Instituto de Assistência Médica ao Servidor Público Estadual
2016-2023
Universidade do Porto
2020
Universidade Federal de São Paulo
2006
Universidade de São Paulo
1994
Carbohydrate antigen 19-9 (CA 19-9) is a tumor marker usually used for the diagnosis and follow-up of pancreatic, gastric, hepatobiliary malignancies. However, it has low specificity can be elevated in wide array other conditions. CA elevation lung tumors seems to associated with worst prognosis, but its role this condition not fully established yet. We present case 78-year-old woman mild consumptive symptoms, consisting unselective anorexia weight loss, isolated high levels 19-9....
Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ CD23+. The usually infiltrate the bone marrow, peripheral blood, lymph nodes, spleen. diagnosis established immunophenotyping circulating B-lymphocytes, prognosis defined two staging systems (Rai Binet) physical examination blood counts, as well several biological genetic markers. In this update, we present recommendations from Brazilian...
Somatic growth is a balance between protein synthesis and degradation, it largely influenced by nutritional clues. Antioxidants levels play key role in turnover reducing the oxidative damage skeletal muscle, hence promoting performance long-term. In present study, Senegalese sole postlarvae (45 days after hatching, DAH) were fed with three experimental diets, control (CTRL) two supplemented natural antioxidants: curcumin (CC) grape seed (GS). Trial spanned for 25 performance, muscle...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, is a pandemic with high morbidity and mortality. Several studies on the use of laboratory markers that can differentiate patients at risk death associated COVID-19 or an unfavourable course from mild to have been proposed recently. In this study, we evaluated hematological parameters 1369 diagnosed Covid-19 unique center Brazil correlated severity. Patients were divided into two groups according...
Chronic lymphocytic leukemia is the most prevalent type of in West. It characterized by an extremely variable clinical course. The aim study was to detect frequent chromosomal abnormalities patients with CLL using FISH, and assess them regarding age, gender, stage CD38 ZAP-70 expressions. We found 51.7% chromosome abnormalities. one del 13q14 34.5% cases. associated other alterations 17.2%. 17p13 deletions were 17.2% trisomy 12 13.8% (in isolation 6.9% 13q14, cases). An 11q22 deletion case a...
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A leucemia linfocítica crônica (LLC) é uma doença linfoproliferativa (DLPC) que apresenta características epidemiológicas peculiares; acomete indivíduos com idade mais avançada (não ocorre em crianças e rara abaixo dos 30 anos) a sua incidência varia conforme origem étnica pacientes. É freqüente nos países ocidentais enquanto muito orientais. etiologia não está ainda esclarecida, se conhecendo fatores ambientais mostrem forte associação o surgimento da doença. Não tem relação radiação...
Introduction: Adult T-cell leukemia/lymphoma (ATL) is a peripheral malignancy caused by human leukemia virus type I (HTLV-1), endemic in some areas of the world, such as Brazil. Between 3% and 5% HTLV-1-infected individuals develop ATL after long latency. The clinical features are heterogeneous classified into acute, lymphoma, chronic smoldering types. Acute lymphoma types defined aggressive whereas others indolent ATL. On April 2017, Brazil project was launched. Methods: Ambispective...
To evaluate the influence of onco-hematological pathologies on seroconversion to COVID-19 vaccines, in addition effects chemotherapy treatment this response.The present study evaluated immunogenic response 76 patients with diseases multiple vaccine platforms compared 25 control individuals.Our results showed positive rates 74.02% and 100% controls. When analyzed according etiological group, lymphoproliferative disorders achieved a rate 58.7%, whereas those myeloproliferative rate. We also...
Paciente de 61 anos apresentou dor abdominal com descompressão brusca positiva e febre. Hb = 6,1 g/dl, Leucócitos 14,76 mil/m3, 12,10 mil/m3 blastos, segmentados 0,15/mm3, plaquetas 23 mil/mm3. Morfologia: 81,0% blastos grande porte, moderada relação N/C, cromatina frouxa, nucléolos presentes, citoplasma granulações finas. CD7, CD11b fraco/parcial, CD13, CD33 forte, CD34, CD38, CD64 parcial (20,9%), CD71 fraco, CD117, CD123 parcial, HLA-DR, MPO. 45,XY,-7[17]/46,XY[3], FISH: Deleção...
A oclusão vascular na doença falciforme é um processo complexo e responsável pela maioria das manifestações clínicas da doença. dor abdominal componente importante crise dolorosa vaso-oclusiva. devido a vaso-oclusiva muitas vezes indistinguível de intra-abdominal aguda, como colecistite pancreatite infarto hepático, colite isquêmica apendicite aguda. Descrevemos caso discutimos o diagnóstico diferencial entre