A5054722146- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Liver Diseases and Immunity
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Intracranial Aneurysms: Treatment and Complications
- COVID-19 Clinical Research Studies
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- T-cell and B-cell Immunology
- Peripheral Neuropathies and Disorders
- Immunotherapy and Immune Responses
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunodeficiency and Autoimmune Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pregnancy and Medication Impact
- Intracerebral and Subarachnoid Hemorrhage Research
- Galectins and Cancer Biology
Aarhus University
2016-2025
Aarhus University Hospital
2016-2025
Institute for Biomedicine
2022-2024
Maastricht University
2023
Instituto Maimónides de Investigación Biomédica de Córdoba
2023
Hospital Universitario Reina Sofía
2023
University of Córdoba
2023
The University of Queensland
2023
Translational Research Institute
2023
Mater Research
2023
Our objective was to update the EULAR recommendations for management of systemic lupus erythematosus (SLE), based on emerging new evidence. We performed a systematic literature review (01/2007-12/2017), followed by modified Delphi method, form questions, elicit expert opinions and reach consensus. Treatment in SLE aims at remission or low disease activity prevention flares. Hydroxychloroquine is recommended all patients with lupus, dose not exceeding 5 mg/kg real body weight. During chronic...
With a vaccine effectiveness of 95% for preventing coronavirus disease 2019 (COVID-19), Pfizer-BioNTech BNT162b2 (BNT162b2) was the first against severe acute respiratory syndrome 2 (SARS-CoV-2) to be approved. However, immunosuppressive therapy an exclusion criterion in phase 3 trial that led approval. Thus, extrapolation results patients with rheumatic diseases treated drugs warrants caution.
Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral defense, but may also promote pathological inflammation. A range diseases characterized by elevated IFN-I, including systemic lupus erythematosus (lupus). The DNA-activated cGAS-STING pathway is a major IFN-I-inducing pathway, activation signaling dependent on trafficking STING from the ER to Golgi.Here we used cell culture systems, mouse model, material patients, explore mode action antagonistic peptide, its...
Summary Since the discovery of lectin pathway complement activation, numerous clinical cohorts have been examined for one or more proteins, with intention uncovering functions proteins aim discovering new biomarkers diagnostic tools. To unveil abnormal, it is pivotal to know normal. Our was describe concentrations 11 known in serum and plasma uncover possible gender differences, age diurnal variations, which must be taken into account investigation different cohorts. We all mannan-binding...
Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in presentation between patients, which likely due to underlying molecular diversity. Here, we aimed at elucidating the genetic aetiology of SLE from immunity pathway level single variant level, and stratify patients into distinguishable subgroups, could inform treatment choices SLE. Methods We undertook a pathway-centred approach, using sequencing immunological genes. Altogether 1832...
We aimed to investigate (1) whether patients with rheumatic disease (RD) treated rituximab (RTX) raise a serological response toward the coronavirus 2019 (COVID-19) mRNA vaccines, and (2) elucidate influence of time since last RTX dose before vaccination on this response.We identified included 201 RDs followed at outpatient clinic Department Rheumatology, Aarhus University Hospital, who had been in period 2017-2021 completed their 2-dose series COVID-19 vaccine. Total antibodies against...
This study aimed to analyse healthcare utilisation patterns in the 5 years preceding a diagnosis of systemic lupus erythematosus (SLE) Denmark compared matched healthy individuals. Understanding these could support earlier and reduce diagnostic delay. A nationwide, registry-based cohort was conducted using data from Danish national registries between 2006 2021. Healthcare utilisation, including general practitioner (GP) visits, specialist consultations, prescriptions, blood tests, imaging,...
Objectives. Toll-like receptors (TLRs) are pattern-associated in innate immunity that may be involved the recognition of self-antigens and production pathogenic autoantibodies. This study was undertaken to examine whether polymorphisms TLR genes associated with SLE determine expression various TLRs peripheral blood mononuclear cells (PBMCs) patients SLE.
The pathogenesis of systemic lupus erythematosus (SLE) involves complement activation. Activation through the classical pathway (CP) is well established. However, activation pattern recognition not only happens CP, but also lectin (LP). We investigated hypothesis that LP activated in SLE and involved disease.Using immunoassays developed in-house, we measured concentrations proteins a cohort 372 patients with 170 controls. estimated measuring total C3, whether protein were associated disease...
In 2012, hypocomplementemia was included in the classification criteria of systemic lupus erythematosus (SLE). The suggested measurement C3 or C4 often reflect disease activity poorly. Our objective to establish an assay measuring C3dg, which is generated following complement activation, and evaluate a cross-sectional SLE cohort.We patients (n = 169) controls 170) developed modified C3dg where fragments were separated from large plasma proteins by polyethylene glycol (PEG), supernatant...
Abstract Systemic Lupus Erythematosus (SLE) is a multifaceted, multisystem autoimmune disorder with diverse clinical expressions. While prevalence reports vary widely, pulmonary involvement accounts for significant morbidity and mortality in SLE. This comprehensive review explores the spectrum of disease SLE, including upper airway manifestations (e.g., laryngeal affection), lower conditions bronchitis, bronchiolitis, bronchiectasis), parenchymal diseases interstitial lung disease, acute...
Rituximab (RTX)-treated patients exhibit suboptimal responses to COVID-19 vaccines. However, existing research primarily involves already receiving RTX when vaccines were introduced, failing account for the current landscape where are vaccinated before initiating RTX. Our objective was compare serological response in or after initiation.
The objective of this study was to explore the involvement collectin liver 1 (CL-L1) and kidney (CL-K1) other pattern recognition molecules (PRMs) lectin pathway complement system in a cross-sectional cohort systemic lupus erythematosus (SLE) patients. Concentrations plasma CL-L1, CL-K1, mannan-binding (MBL), M-ficolin, H-ficolin L-ficolin were determined 58 patients with SLE 65 healthy controls using time-resolved immunoflourometric assays. patients' demographic, diagnostic, clinical...
Human endogenous retroviruses (HERVs) are remnants of past retroviral infections in the human genome and have been implicated different aspects biology. The aim this study was to identify HERVs that associated with pathogenesis rheumatic diseases such as systemic lupus erythematosus (SLE).The subjects included 45 female patients SLE 50 healthy controls matched for geographic area, age, sex. Real-time reverse transcription-polymerase chain reaction analysis used examine transcription levels...
Objective To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods Patients with SLE (n discovery cohort =776, n replication =836) were genotyped using 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs association (p<5.0×10 −8 ) analysed. Signal transducer activator transcription 4 (STAT4) activation was assessed in vitro stimulated peripheral blood mononuclear cells...