A5066540209- Advanced Proteomics Techniques and Applications
- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- Cell Image Analysis Techniques
- Advanced biosensing and bioanalysis techniques
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Radiomics and Machine Learning in Medical Imaging
- Analytical Chemistry and Sensors
- Medical Image Segmentation Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Gene expression and cancer classification
- Biochemical Acid Research Studies
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Cutaneous Melanoma Detection and Management
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Neurological Disease Mechanisms and Treatments
- Coenzyme Q10 studies and effects
- Nonmelanoma Skin Cancer Studies
- Genomics and Rare Diseases
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2022-2024
Institute for Microelectronics and Microsystems
2015-2017
Istituto Nazionale di Fisica Nucleare
2008-2013
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud
2013
University of Salento
2008-2012
University of Bari Aldo Moro
2012
University of Genoa
2012
University of Turin
2012
University of Catania
2012
Istituto Nazionale di Fisica Nucleare, Sezione di Lecce
2008
Voluntary runners are subjected to a massive increase in reactive oxygen/nitrogen species production, which can promote different oxidative stress-related diseases such as premature aging, neurodegenerative disorders, and cancer. The aims of this work were evaluate the following peripheral blood cells voluntary runners: (i) DNA status; (ii) susceptibility vitro insult induced by hydrogen peroxide (H(2)O(2)) breaking agent; (iii) capabilities 3,5,4'-trihydroxystilbene (RESV) counteracting...
Laser accelerated proton beams have been proposed to be used in different research fields. A great interest has risen for the potential replacement of conventional accelerating machines with laser-based accelerators, and particular development new concepts more compact cheaper hadrontherapy centers. In this context ELIMED (ELI MEDical applications) project launched by INFN-LNS ASCR-FZU researchers within pan-European ELI-Beamlines facility framework. The aims demonstrate clinical...
In this work, we simulated and experimentally assessed the possibility to detect, through electrical transduction, hybridization of DNA molecules on MOS-like devices, having different dielectrics: SiO2, Si3N4 SiO2/Si3N4/SiO2 (ONO). The characterization was performed after various functionalization steps, consisting dielectric activation, silanization, spotting anchoring, process, test devices effectiveness as recognition biosensors. experimental results were used validate device simulations....
ABSTRACT OBJECTIVES We detail a procedure for generating set of templates the hippocampal region in magnetic resonance (MR) images, representative clinical conditions population under investigation. METHODS The first step is robust standardization intensity scale brain MR belonging to patients with different degrees neuropathology (Alzheimer's disease). So similar tissues have intensities, even across images coming from sources. After automatic extraction large dataset we address template...
We demonstrate a method to characterize the beam energy, transverse profile, charge, and dose of pulsed electron generated by 1 kHz TW laser-plasma accelerator. The is based on imaging with scintillating screen in an inhomogeneous, orthogonal magnetic field produced wide-gap dipole. Numerical simulations were developed reconstruct parameters accurately. has been experimentally verified calibrated using medical LINAC. energy measurement accuracy 6–20 MeV range proven be better than 10%....
This paper proposes a new segmentation method for the delimitation of lung parenchyma in thorax Computed-Tomography (CT) datasets, which will be used as pre-processing step CAD (Computer Assisted Detection) system nodule detection that is being developed by MAGIC-5 (Medical Applications Grid Infrastructure Connection) Collaboration. Once finished, software run an integrated "grid" environment, where potentiality distributed resources both data and computation exploited. The algorithm fully...
Our group has started a project aiming at the development of analysis algorithms devoted to images produced by two-dimensional electrophoresis (2-DE) for general applications in field proteomics. General problems have been addressed, with ultimate goal maximization "automation level" procedure, without reducing accuracy now reachable only manual intervention. For this, is analyzing 2-DE that are already stored or will be means instrumentation and know-how biologists participating project....
Our working group has started a project aiming at the development of analysis algorithms devoted to images produced by two-dimensional electrophoresis (2-DE) for general applications in field proteomics. General problems have been addressed, with ultimate goal maximization "automation level" procedure, without reducing accuracy now reachable only manual intervention. For this purpose, is analyzing 2-DE that real ready stored or will be means instrumentation and know-how biologists...
A new source of relativistic electrons based on laser wakefield acceleration has been recently built and commissioned at ELI-Beamlines user facility. This platform is proposed for the experimental study radiation to electronics effects components devices dimensioned laboratory low Earth orbit applications, such as picosatellite class spacecrafts, e.g. CubeSat. The device configured represent energy range trapped in Van Allen belts, 0.1 – 10 MeV, ultra-high dose rates radiation. developed...
Studies regarding the radiobiological effects of low dose radiation, microbeam irradiation services have been developed in world and today laser acceleration protons heavy ions may be used radiation therapy. The application different facilities is essential for studying bystander relating signalling phenomena cells or tissues. In particular use ion beams results advantageous cancer radiotherapy compared to more commonly X-rays, since ability delivering lethal amount doses into target tumour...
Proteomics is the science that studies proteome, proteic expression of genome. Cell proteome extremely complex, and composed several thousand proteins. Twodimensional polyacrylamide gel electrophoresis (2DPAGE) widely used as a standard method to separate display proteins in tissue or compound with theoretical resolution 104 simultaneously. This technique combines power isoelectrofocalization (IEF), which distinguishes by their isoelectric point (pI), SDSPAGE (sodium dodecyl sulphate PAGE),...