Scope Recent evidences demonstrate that abnormal gut microbiota (GM) might be involved in the pathogenesis of Alzheimer's disease (AD). However, role probiotics preventing AD by regulating GM–gut–brain axis remains unclear. Here, anti‐neuroinflammatory effect and its mechanism probiotic Clostridium butyricum (CB) against is investigated axis. Methods results APPswe/PS1dE9 (APP/PS1) transgenic are treated intragastrically with CB for 4 weeks then cognitively tested. Amyloid‐β (Aβ) burden,...

To survey the health-related quality of life (HRQoL) and its influencing factors among patients with COVID-19 in their first medical follow up.All diagnosed were discharged from 12 hospitals Wenzhou, Zhejiang Jan 17, 2020 to Mar 20, 2020. Prospectively collected analyzed data included demographics, clinical symptoms, comorbidity, chest CT imaging features at up, 1 month after discharge. All underwent HRQoL evaluation Chinese version Short-Form 36-item questionnaire (SF-36) as well a general...

Poststroke inflammation is essential in the mechanism of secondary injury, and it orchestrated by resident microglia, astrocytes, circulating immune cells. Edaravone dexborneol (EDB) a combination edaravone borneol that has been identified as clinical protectant for stroke management. In this study, we verified anti-inflammatory effect EDB mouse model ischemia investigated its modulatory action on inflammation-related C57BL/6 male mice, which had transient middle cerebral artery occlusion...

ABSTRACT The interferon (IFN) system, including various IFNs and IFN-inducible gene products, is well known for its potent innate immunity against wide-range viruses. Recently, a family of cytidine deaminases, functioning as another retroviral infection, has been identified. However, regulation remains largely unknown. In this report, we demonstrate that through regular IFN-α/β signal transduction pathway, IFN-α can significantly enhance the expression apolipoprotein B mRNA-editing...

Cellular cytidine deaminases APOBEC3 family is a group of potent inhibitors for many exogenous and endogenous retroviruses. It has been demonstrated that they induce G to A hypermutations in the nascent retroviral DNA, resulting from cytosine (C) uracil (U) conversions minus-stranded viral DNA. In this report, we have result C U conversion DNA human immunodeficiency virus type 1 (HIV-1) could trigger degradation mediated by glycosylases-2 (UNG2) apurinic/apyrimidinic endonuclease (APE)....

Abstract Ischemic stroke is a frequent cause of mortality and disability, astrocyte reactivity closely associated with injury outcomes. Fibroblast growth factor 21 (FGF21), an endogenous regulator, has been shown to perform pleiotropic functions in central nervous system (CNS) disorders. However, studies on neurological diseases have paid little attention the effects detailed mechanisms FGF21 astrocytes. Here, we found elevated serum levels patients transient middle cerebral artery occlusion...

Light, as an energy source, has been proven to strongly affect photosynthesis and, thus, can regulate the yield and quality of tea leaves (Camellia sinensis L.). However, few comprehensive studies have investigated synergistic effects light wavelengths on growth development in green albino varieties. Thus, objective this study was investigate different ratios red, blue yellow their plants’ quality. In study, Zhongcha108 (green variety) Zhongbai4 (albino were exposed lights for a photoperiod...

Abstract Background The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) method has been used to evaluate glymphatic system function in patients with migraine. However, since model cannot accurately describe coefficient of nerve fibre crossing region, we proposed a kurtosis ALPS (DKI-ALPS) Methods study included 29 healthy controls and 37 We data from 3T MRI scanner calculate DTI-ALPS DKI-ALPS indices two groups. compared between groups using two-sample t-test...

Objectives: To estimate the prevalence of dyslipidemia and its associated influence factors in young adults southeastern coastal area China. Methods:This study used a cross-sectional survey. We conducted this among 7,859 people with health examination three hospitals Wenzhou, Zhejiang province between April 2017 December 2018.All subjects completed questionnaire during face-to-face interviews, examined for anthropometric measurements biochemical tests. Continuous data were presented as means...

To investigate the relationship between symptom of attention-deficit/hyperactivity disorder (ADHD) and allergic rhinitis (AR) in AR children different genders ages. Four hundred sixty-five aged 6–12 years old were recruited this study. Skin-prick test, Pediatric Rhinoconjunctivitis Quality Life Questionnaire (PRQLQ), Total Nasal Symptoms Score (TNSS) Swanson, Nolan, Pelham version IV scale (SNAP-IV) recorded. Patients divided into with ADHD without ADHD, according to SNAP-IV results....

Background and Objectives Neurological manifestations associated with sphenoid sinus mucocele (SSM) are easily misdiagnosed due to nonspecific symptoms. The objective is analyze report the clinical features of SSM presenting neurological manifestations, allow an earlier diagnosis more timely intervention for this disease. Methods This was a retrospective cross‐sectional study including 19 patients. detailed information patients initial symptom caused by at Second Affiliated Hospital Wenzhou...

Abstract Background Few studies have compared the etiology and clinical features between pure lateral medullary infarction (LMI) medial (MMI). Methods All patients included were hospitalized at The First Affiliated Hospital Second of Wenzhou Medical University from January 2015 to July 2020. Their risk factors, manifestation, stroke mechanisms short‐term prognosis analyzed retrospectively. Results Among 387 enrolled, 266 (68.7%) had LMI, 109 (28.2%) MMI, 12 (3.1%) (nine men three women) LMI...

Objectives: The periaqueductal gray (PAG) is a key region in the descending pain modulatory system. We applied Granger causality analysis-based approach to examine resting-state effective connectivity of bilateral PAG regions migraine patients without aura (MwoA). Materials and Methods: Resting-state functional magnetic resonance imaging data were obtained from 28 MwoA 17 healthy controls. was characterized using voxel-wised analysis method. resulting measurements assessed for correlations...

Abstract Introduction Occupational stress is considered to be a harmful physical and emotional response an individual's psychological and/or physiological state in the work environment highly prevalent among medical staff. However, few epidemiological studies have investigated occupational Our study aims explore characteristics of its relationship with dyslipidemia Chinese staff at tertiary hospitals establish basis for future preventive strategies. Methods A cross‐sectional was conducted...

Few researches have looked at the relationship between nonalcoholic fatty liver disease (NAFLD) time of admission and long-term outcomes patients suffering from acute ischemic stroke (AIS). We aimed to probe NAFLD risk evaluated by indices endpoints, along with prognostic value merging established markers for prognosis AIS patients. The index (FLI) Hepatic steatosis (HSI) were used evaluate in Third China National Stroke Registry (CNSR-III), a large, prospective, national, multicenter cohort...

Intracerebral hemorrhage (ICH) is the most prevalent cause of death. We sought to explore whether serum Fibroblast growth factor 21 (FGF21) substantial benefit in predicting poor prognosis ICH patient.A prospective, multicenter cohort analysis FGF21 levels 418 patients was carried out. At three months following start, primary endpoint death or major disability, whereas secondary investigated association between and clinical outcomes. added existing rating scale assess it enhanced prediction...

Abstract Objective To observe the clinical effect of botulinum toxin type A (BTA) injection into salivary glands severe neurological patients with tracheotomy Methods Seven disorders after and obvious drooling symptoms were enrolled. BTA was injected bilateral parotid submandibular under guidance ultrasound. Unstimulated flow rate (uSFR) Drooling Severity Frequency Scale (DSFS) used to evaluate before injection, 1 week, 4 weeks injection. We compared extubation time, time changing from...

<title>Abstract</title> <bold>Background</bold>: Usher syndrome is a genetic disorder characterized by sensorineural hearing loss, progressive vision and in some cases, vestibular dysfunction. It the most common cause of combined deafness blindness. <italic>Cep250</italic> candidate gene for atypical syndrome. This study explores inner ear morphological auditory functional changes using <italic>Cep250</italic>^−/− mouse model. <bold>Methods</bold>: We constructed...